| pubmed-article:1826051 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:1826051 | lifeskim:mentions | umls-concept:C0026809 | lld:lifeskim |
| pubmed-article:1826051 | lifeskim:mentions | umls-concept:C0024880 | lld:lifeskim |
| pubmed-article:1826051 | lifeskim:mentions | umls-concept:C0026010 | lld:lifeskim |
| pubmed-article:1826051 | lifeskim:mentions | umls-concept:C0009498 | lld:lifeskim |
| pubmed-article:1826051 | lifeskim:mentions | umls-concept:C1457869 | lld:lifeskim |
| pubmed-article:1826051 | lifeskim:mentions | umls-concept:C0596988 | lld:lifeskim |
| pubmed-article:1826051 | lifeskim:mentions | umls-concept:C0079053 | lld:lifeskim |
| pubmed-article:1826051 | lifeskim:mentions | umls-concept:C1441547 | lld:lifeskim |
| pubmed-article:1826051 | pubmed:issue | 6 | lld:pubmed |
| pubmed-article:1826051 | pubmed:dateCreated | 1991-4-25 | lld:pubmed |
| pubmed-article:1826051 | pubmed:abstractText | Mutations at three loci in the mouse--W, Steel Sl), and microphthalmia (mi)--can lead to a deficiency in melanocytes and mast cells. As well, W and Sl mutants can be anemic and sterile, whereas mi mice are osteopetrotic due to a monocyte/macrophage defect. Recent data have shown that the c-kit receptor tyrosine kinase is the gene product of the W locus, whereas Sl encodes the ligand for this growth factor receptor. We show here that ectopic expression of c-fms, a gene that encodes a macrophage growth factor receptor that is closely related to the c-kit receptor, complements mutations at the W locus in an in vitro mast cell/fibroblast coculture system but is unable to reverse the inability of mi/mi mast cells to survive under these conditions. Furthermore, mast cells expressing the c-fms receptor survive on a monolayer of fibroblasts homozygous for the Sl mutation. These results suggest that ligand binding to the c-kit or c-fms receptor activates identical or overlapping signal transduction pathways. Furthermore, they suggest that mi encodes a protein necessary for transducing signals mediated by way of either the c-kit or c-fms receptor. | lld:pubmed |
| pubmed-article:1826051 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1826051 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1826051 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1826051 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1826051 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1826051 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1826051 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1826051 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1826051 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1826051 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1826051 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1826051 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1826051 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1826051 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1826051 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1826051 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1826051 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1826051 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1826051 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1826051 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1826051 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1826051 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1826051 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1826051 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1826051 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1826051 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1826051 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1826051 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1826051 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1826051 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1826051 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1826051 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1826051 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1826051 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1826051 | pubmed:language | eng | lld:pubmed |
| pubmed-article:1826051 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1826051 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:1826051 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1826051 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1826051 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:1826051 | pubmed:month | Mar | lld:pubmed |
| pubmed-article:1826051 | pubmed:issn | 0027-8424 | lld:pubmed |
| pubmed-article:1826051 | pubmed:author | pubmed-author:BernsteinAA | lld:pubmed |
| pubmed-article:1826051 | pubmed:author | pubmed-author:FujitaJJ | lld:pubmed |
| pubmed-article:1826051 | pubmed:author | pubmed-author:ReedijkMM | lld:pubmed |
| pubmed-article:1826051 | pubmed:author | pubmed-author:RottapelRR | lld:pubmed |
| pubmed-article:1826051 | pubmed:author | pubmed-author:DubreuilPP | lld:pubmed |
| pubmed-article:1826051 | pubmed:author | pubmed-author:ForresterLL | lld:pubmed |
| pubmed-article:1826051 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:1826051 | pubmed:day | 15 | lld:pubmed |
| pubmed-article:1826051 | pubmed:volume | 88 | lld:pubmed |
| pubmed-article:1826051 | pubmed:geneSymbol | c-fms | lld:pubmed |
| pubmed-article:1826051 | pubmed:geneSymbol | mi | lld:pubmed |
| pubmed-article:1826051 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:1826051 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:1826051 | pubmed:pagination | 2341-5 | lld:pubmed |
| pubmed-article:1826051 | pubmed:dateRevised | 2009-11-19 | lld:pubmed |
| pubmed-article:1826051 | pubmed:meshHeading | pubmed-meshheading:1826051-... | lld:pubmed |
| pubmed-article:1826051 | pubmed:meshHeading | pubmed-meshheading:1826051-... | lld:pubmed |
| pubmed-article:1826051 | pubmed:meshHeading | pubmed-meshheading:1826051-... | lld:pubmed |
| pubmed-article:1826051 | pubmed:meshHeading | pubmed-meshheading:1826051-... | lld:pubmed |
| pubmed-article:1826051 | pubmed:meshHeading | pubmed-meshheading:1826051-... | lld:pubmed |
| pubmed-article:1826051 | pubmed:meshHeading | pubmed-meshheading:1826051-... | lld:pubmed |
| pubmed-article:1826051 | pubmed:meshHeading | pubmed-meshheading:1826051-... | lld:pubmed |
| pubmed-article:1826051 | pubmed:meshHeading | pubmed-meshheading:1826051-... | lld:pubmed |
| pubmed-article:1826051 | pubmed:meshHeading | pubmed-meshheading:1826051-... | lld:pubmed |
| pubmed-article:1826051 | pubmed:meshHeading | pubmed-meshheading:1826051-... | lld:pubmed |
| pubmed-article:1826051 | pubmed:meshHeading | pubmed-meshheading:1826051-... | lld:pubmed |
| pubmed-article:1826051 | pubmed:meshHeading | pubmed-meshheading:1826051-... | lld:pubmed |
| pubmed-article:1826051 | pubmed:meshHeading | pubmed-meshheading:1826051-... | lld:pubmed |
| pubmed-article:1826051 | pubmed:meshHeading | pubmed-meshheading:1826051-... | lld:pubmed |
| pubmed-article:1826051 | pubmed:meshHeading | pubmed-meshheading:1826051-... | lld:pubmed |
| pubmed-article:1826051 | pubmed:meshHeading | pubmed-meshheading:1826051-... | lld:pubmed |
| pubmed-article:1826051 | pubmed:year | 1991 | lld:pubmed |
| pubmed-article:1826051 | pubmed:articleTitle | The c-fms gene complements the mitogenic defect in mast cells derived from mutant W mice but not mi (microphthalmia) mice. | lld:pubmed |
| pubmed-article:1826051 | pubmed:affiliation | Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Canada. | lld:pubmed |
| pubmed-article:1826051 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:1826051 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:1826051 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:1826051 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:1826051 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:1826051 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:1826051 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:1826051 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:1826051 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:1826051 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:1826051 | lld:pubmed |
