| pubmed-article:1826018 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:1826018 | lifeskim:mentions | umls-concept:C0007589 | lld:lifeskim |
| pubmed-article:1826018 | lifeskim:mentions | umls-concept:C1155008 | lld:lifeskim |
| pubmed-article:1826018 | lifeskim:mentions | umls-concept:C0020846 | lld:lifeskim |
| pubmed-article:1826018 | lifeskim:mentions | umls-concept:C0123242 | lld:lifeskim |
| pubmed-article:1826018 | lifeskim:mentions | umls-concept:C0023688 | lld:lifeskim |
| pubmed-article:1826018 | lifeskim:mentions | umls-concept:C1327944 | lld:lifeskim |
| pubmed-article:1826018 | lifeskim:mentions | umls-concept:C0205296 | lld:lifeskim |
| pubmed-article:1826018 | lifeskim:mentions | umls-concept:C1511938 | lld:lifeskim |
| pubmed-article:1826018 | lifeskim:mentions | umls-concept:C1292733 | lld:lifeskim |
| pubmed-article:1826018 | pubmed:issue | 7 | lld:pubmed |
| pubmed-article:1826018 | pubmed:dateCreated | 1991-4-22 | lld:pubmed |
| pubmed-article:1826018 | pubmed:abstractText | The possible role of CD23 in the activation of human B lymphocytes was systematically investigated by examining the effect of: 1) anti-CD23 mAb; 2) IgE or IgE-immune complexes and; 3) native or recombinant soluble CD23 of different m.w., on B cell proliferation. Intact anti-CD23 mAb or its F(ab')2 fragments inhibit the proliferation of tonsillar B lymphocytes costimulated with either Staphylococcus aureus Cowan I (SAC) or anti-IgM and IL-4. The antibody has no effect when IL-2 or LMW-BCGF is used as the second stimulant. The response of IL-4-pretreated B cells (expressing high levels of CD23) to anti-IgM together with IL-2 or B cell-derived B cell growth factor is inhibited by anti-CD23 mAb, indicating that this antibody prevents B cell activation regardless of the B cell activators but provided that the density of CD23 on B cells is sufficient. Anti-CD23 mAb markedly inhibits DNA synthesis only when added during the first 12 h of the culture and has no effect on the ongoing proliferation of CD23-bearing B cell blasts (SAC induced and IL-4 supported or EBV transformed). Monovalent Fab fragments of anti-CD23 mAb are inactive unless they are used in tandem with goat anti-mouse Fab suggesting that the inhibition is due to cross-linking of surface CD23. Most interestingly, polymeric IgE or IgE-immune complexes have the same effect as anti-CD23 and moreover they inhibit IgM production by SAC and IL4-stimulated B cells. The inhibiting effect of IgE or of anti-CD23 mAb is not due to their neutralization of soluble CD23 because these failed to display B cell growth factor activity under various experimental conditions. It is concluded that IgE-immune complexes may regulate activation and differentiation of CD23-bearing surfaceIgM/surfaceIgD precursor B lymphocytes. | lld:pubmed |
| pubmed-article:1826018 | pubmed:language | eng | lld:pubmed |
| pubmed-article:1826018 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1826018 | pubmed:citationSubset | AIM | lld:pubmed |
| pubmed-article:1826018 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1826018 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1826018 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1826018 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1826018 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1826018 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:1826018 | pubmed:month | Apr | lld:pubmed |
| pubmed-article:1826018 | pubmed:issn | 0022-1767 | lld:pubmed |
| pubmed-article:1826018 | pubmed:author | pubmed-author:DelespesseGG | lld:pubmed |
| pubmed-article:1826018 | pubmed:author | pubmed-author:HofstetterHH | lld:pubmed |
| pubmed-article:1826018 | pubmed:author | pubmed-author:BanchereauJJ | lld:pubmed |
| pubmed-article:1826018 | pubmed:author | pubmed-author:LuoH YHY | lld:pubmed |
| pubmed-article:1826018 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:1826018 | pubmed:day | 1 | lld:pubmed |
| pubmed-article:1826018 | pubmed:volume | 146 | lld:pubmed |
| pubmed-article:1826018 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:1826018 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:1826018 | pubmed:pagination | 2122-9 | lld:pubmed |
| pubmed-article:1826018 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
| pubmed-article:1826018 | pubmed:meshHeading | pubmed-meshheading:1826018-... | lld:pubmed |
| pubmed-article:1826018 | pubmed:meshHeading | pubmed-meshheading:1826018-... | lld:pubmed |
| pubmed-article:1826018 | pubmed:meshHeading | pubmed-meshheading:1826018-... | lld:pubmed |
| pubmed-article:1826018 | pubmed:meshHeading | pubmed-meshheading:1826018-... | lld:pubmed |
| pubmed-article:1826018 | pubmed:meshHeading | pubmed-meshheading:1826018-... | lld:pubmed |
| pubmed-article:1826018 | pubmed:meshHeading | pubmed-meshheading:1826018-... | lld:pubmed |
| pubmed-article:1826018 | pubmed:meshHeading | pubmed-meshheading:1826018-... | lld:pubmed |
| pubmed-article:1826018 | pubmed:meshHeading | pubmed-meshheading:1826018-... | lld:pubmed |
| pubmed-article:1826018 | pubmed:meshHeading | pubmed-meshheading:1826018-... | lld:pubmed |
| pubmed-article:1826018 | pubmed:meshHeading | pubmed-meshheading:1826018-... | lld:pubmed |
| pubmed-article:1826018 | pubmed:meshHeading | pubmed-meshheading:1826018-... | lld:pubmed |
| pubmed-article:1826018 | pubmed:year | 1991 | lld:pubmed |
| pubmed-article:1826018 | pubmed:articleTitle | Cross-linking of CD23 antigen by its natural ligand (IgE) or by anti-CD23 antibody prevents B lymphocyte proliferation and differentiation. | lld:pubmed |
| pubmed-article:1826018 | pubmed:affiliation | University of Montreal, Notre-Dame Hospital, Research Center, Canada. | lld:pubmed |
| pubmed-article:1826018 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:1826018 | pubmed:publicationType | In Vitro | lld:pubmed |
| pubmed-article:1826018 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:1826018 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:1826018 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:1826018 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:1826018 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:1826018 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:1826018 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:1826018 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:1826018 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:1826018 | lld:pubmed |
