| pubmed-article:18253884 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:18253884 | lifeskim:mentions | umls-concept:C0027651 | lld:lifeskim |
| pubmed-article:18253884 | lifeskim:mentions | umls-concept:C0027686 | lld:lifeskim |
| pubmed-article:18253884 | lifeskim:mentions | umls-concept:C0431085 | lld:lifeskim |
| pubmed-article:18253884 | lifeskim:mentions | umls-concept:C0596290 | lld:lifeskim |
| pubmed-article:18253884 | lifeskim:mentions | umls-concept:C0021467 | lld:lifeskim |
| pubmed-article:18253884 | lifeskim:mentions | umls-concept:C0018270 | lld:lifeskim |
| pubmed-article:18253884 | lifeskim:mentions | umls-concept:C0021469 | lld:lifeskim |
| pubmed-article:18253884 | lifeskim:mentions | umls-concept:C0053428 | lld:lifeskim |
| pubmed-article:18253884 | pubmed:issue | 1-2 | lld:pubmed |
| pubmed-article:18253884 | pubmed:dateCreated | 2008-2-6 | lld:pubmed |
| pubmed-article:18253884 | pubmed:abstractText | In the present study, we investigated the potential anti-angiogenic mechanism and anti-tumour activity of beta-eudesmol using in vitro and in vivo experimental models. Proliferation of human umbilical vein endothelial cells (HUVEC) stimulated with vascular endothelial growth factor (VEGF, 30 ng/ml) and basic fibroblast growth factor (bFGF, 30 ng/ml) was significantly inhibited by beta-eudesmol (50-100 microM). Beta-eudesmol (100 microM) also blocked the phosphorylation of cAMP response element binding protein (CREB) induced by VEGF (30 ng/ml) in HUVEC. Beta-eudesmol (10-100 microM) inhibited proliferation of HeLa, SGC-7901, and BEL-7402 tumour cells in a time- and dose-dependent manner. Moreover, beta-eudesmol treatment (2.5-5 mg/kg) significantly inhibited growth of H(22) and S(180) mouse tumour in vivo. These results indicated that beta-eudesmol inhibited angiogenesis by suppressing CREB activation in growth factor signalling pathway. This is the first study to demonstrate that beta-eudesmol is an inhibitor of tumour growth. | lld:pubmed |
| pubmed-article:18253884 | pubmed:language | eng | lld:pubmed |
| pubmed-article:18253884 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18253884 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:18253884 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18253884 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18253884 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18253884 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18253884 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18253884 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18253884 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:18253884 | pubmed:issn | 1028-6020 | lld:pubmed |
| pubmed-article:18253884 | pubmed:author | pubmed-author:KimuraIkukoI | lld:pubmed |
| pubmed-article:18253884 | pubmed:author | pubmed-author:WangMin-WeiMW | lld:pubmed |
| pubmed-article:18253884 | pubmed:author | pubmed-author:TsunekiHirosh... | lld:pubmed |
| pubmed-article:18253884 | pubmed:author | pubmed-author:XiaoJin-FangJ... | lld:pubmed |
| pubmed-article:18253884 | pubmed:author | pubmed-author:XiaMing-YuMY | lld:pubmed |
| pubmed-article:18253884 | pubmed:author | pubmed-author:LiYan-ChunYC | lld:pubmed |
| pubmed-article:18253884 | pubmed:author | pubmed-author:MaEn-LongEL | lld:pubmed |
| pubmed-article:18253884 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:18253884 | pubmed:volume | 10 | lld:pubmed |
| pubmed-article:18253884 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:18253884 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:18253884 | pubmed:pagination | 159-67 | lld:pubmed |
| pubmed-article:18253884 | pubmed:dateRevised | 2009-7-21 | lld:pubmed |
| pubmed-article:18253884 | pubmed:meshHeading | pubmed-meshheading:18253884... | lld:pubmed |
| pubmed-article:18253884 | pubmed:meshHeading | pubmed-meshheading:18253884... | lld:pubmed |
| pubmed-article:18253884 | pubmed:meshHeading | pubmed-meshheading:18253884... | lld:pubmed |
| pubmed-article:18253884 | pubmed:meshHeading | pubmed-meshheading:18253884... | lld:pubmed |
| pubmed-article:18253884 | pubmed:meshHeading | pubmed-meshheading:18253884... | lld:pubmed |
| pubmed-article:18253884 | pubmed:meshHeading | pubmed-meshheading:18253884... | lld:pubmed |
| pubmed-article:18253884 | pubmed:meshHeading | pubmed-meshheading:18253884... | lld:pubmed |
| pubmed-article:18253884 | pubmed:meshHeading | pubmed-meshheading:18253884... | lld:pubmed |
| pubmed-article:18253884 | pubmed:meshHeading | pubmed-meshheading:18253884... | lld:pubmed |
| pubmed-article:18253884 | pubmed:meshHeading | pubmed-meshheading:18253884... | lld:pubmed |
| pubmed-article:18253884 | pubmed:meshHeading | pubmed-meshheading:18253884... | lld:pubmed |
| pubmed-article:18253884 | pubmed:meshHeading | pubmed-meshheading:18253884... | lld:pubmed |
| pubmed-article:18253884 | pubmed:meshHeading | pubmed-meshheading:18253884... | lld:pubmed |
| pubmed-article:18253884 | pubmed:meshHeading | pubmed-meshheading:18253884... | lld:pubmed |
| pubmed-article:18253884 | pubmed:meshHeading | pubmed-meshheading:18253884... | lld:pubmed |
| pubmed-article:18253884 | pubmed:meshHeading | pubmed-meshheading:18253884... | lld:pubmed |
| pubmed-article:18253884 | pubmed:meshHeading | pubmed-meshheading:18253884... | lld:pubmed |
| pubmed-article:18253884 | pubmed:meshHeading | pubmed-meshheading:18253884... | lld:pubmed |
| pubmed-article:18253884 | pubmed:meshHeading | pubmed-meshheading:18253884... | lld:pubmed |
| pubmed-article:18253884 | pubmed:articleTitle | Beta-eudesmol suppresses tumour growth through inhibition of tumour neovascularisation and tumour cell proliferation. | lld:pubmed |
| pubmed-article:18253884 | pubmed:affiliation | Department of Pharmacology, Shenyang Pharmaceutical University, Shenyang, China. maenlong@hotmail.com | lld:pubmed |
| pubmed-article:18253884 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:18253884 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
