| pubmed-article:18087278 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:18087278 | lifeskim:mentions | umls-concept:C0004927 | lld:lifeskim |
| pubmed-article:18087278 | lifeskim:mentions | umls-concept:C0024623 | lld:lifeskim |
| pubmed-article:18087278 | lifeskim:mentions | umls-concept:C0039198 | lld:lifeskim |
| pubmed-article:18087278 | lifeskim:mentions | umls-concept:C0332281 | lld:lifeskim |
| pubmed-article:18087278 | lifeskim:mentions | umls-concept:C1416467 | lld:lifeskim |
| pubmed-article:18087278 | lifeskim:mentions | umls-concept:C0475264 | lld:lifeskim |
| pubmed-article:18087278 | lifeskim:mentions | umls-concept:C0205210 | lld:lifeskim |
| pubmed-article:18087278 | lifeskim:mentions | umls-concept:C0449774 | lld:lifeskim |
| pubmed-article:18087278 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:18087278 | pubmed:dateCreated | 2008-1-9 | lld:pubmed |
| pubmed-article:18087278 | pubmed:abstractText | It has been reported that the population of regulatory T cells (T regs) is increased in tumour-infiltrating lymphocytes in cancer-bearing hosts. Recently, forkhead/winged helix transcription factor p3, Foxp3, is thought to be the most reliable marker of T regs. In the present study, we investigated the prevalence and localisation pattern of Foxp3+ cells in gastric cancer (n=80) by immunohistochemistry, in relation to the clinical outcome of gastric cancer patients. Immunohistochemical staining was performed with anti-Foxp3 mAb, and Foxp3+ cells were semiquantified. We divided all cases into two groups: Foxp3+ -high (n=40) and Foxp3+ -low (n=40) groups, by the median size of the population of Foxp3+ cells. Furthermore, in terms of the localisation pattern of accumulating Foxp3+ cells in tumours, we classified all cases into three groups: a peri-tumour group (n=30), a diffuse group (n=40), and a follicular group (n=10). As a result, although the populations of Foxp3+ cells in stage IV were significantly larger than those in stage I (P<0.05), there was no significant difference in survival between the patients with high and low population levels of Foxp3+ cells. However, survival in patients with a diffuse pattern of Foxp3+ cells was significantly poorer than in those with a peri-tumoral pattern. In conclusion, the localisation pattern, but not the population size, of Foxp3+ cells was significantly related to patient survival. | lld:pubmed |
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| pubmed-article:18087278 | pubmed:language | eng | lld:pubmed |
| pubmed-article:18087278 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18087278 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:18087278 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:18087278 | pubmed:month | Jan | lld:pubmed |
| pubmed-article:18087278 | pubmed:issn | 0007-0920 | lld:pubmed |
| pubmed-article:18087278 | pubmed:author | pubmed-author:FujiiHH | lld:pubmed |
| pubmed-article:18087278 | pubmed:author | pubmed-author:KonoKK | lld:pubmed |
| pubmed-article:18087278 | pubmed:author | pubmed-author:KawaguchiYY | lld:pubmed |
| pubmed-article:18087278 | pubmed:author | pubmed-author:KamimuraKK | lld:pubmed |
| pubmed-article:18087278 | pubmed:author | pubmed-author:MizukamiYY | lld:pubmed |
| pubmed-article:18087278 | pubmed:author | pubmed-author:SugarSS | lld:pubmed |
| pubmed-article:18087278 | pubmed:author | pubmed-author:AkaikeHH | lld:pubmed |
| pubmed-article:18087278 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:18087278 | pubmed:day | 15 | lld:pubmed |
| pubmed-article:18087278 | pubmed:volume | 98 | lld:pubmed |
| pubmed-article:18087278 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:18087278 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:18087278 | pubmed:pagination | 148-53 | lld:pubmed |
| pubmed-article:18087278 | pubmed:dateRevised | 2010-9-22 | lld:pubmed |
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| pubmed-article:18087278 | pubmed:year | 2008 | lld:pubmed |
| pubmed-article:18087278 | pubmed:articleTitle | Localisation pattern of Foxp3+ regulatory T cells is associated with clinical behaviour in gastric cancer. | lld:pubmed |
| pubmed-article:18087278 | pubmed:affiliation | First Department of Surgery, University of Yamanashi, 1110 Shimokato, Chuo-City, Yamanashi 409-3898, Japan. | lld:pubmed |
| pubmed-article:18087278 | pubmed:publicationType | Journal Article | lld:pubmed |
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