| pubmed-article:18081038 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:18081038 | lifeskim:mentions | umls-concept:C0011306 | lld:lifeskim |
| pubmed-article:18081038 | lifeskim:mentions | umls-concept:C1704632 | lld:lifeskim |
| pubmed-article:18081038 | lifeskim:mentions | umls-concept:C0871261 | lld:lifeskim |
| pubmed-article:18081038 | lifeskim:mentions | umls-concept:C0205217 | lld:lifeskim |
| pubmed-article:18081038 | lifeskim:mentions | umls-concept:C1336692 | lld:lifeskim |
| pubmed-article:18081038 | lifeskim:mentions | umls-concept:C2911692 | lld:lifeskim |
| pubmed-article:18081038 | lifeskim:mentions | umls-concept:C1706817 | lld:lifeskim |
| pubmed-article:18081038 | lifeskim:mentions | umls-concept:C0178959 | lld:lifeskim |
| pubmed-article:18081038 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:18081038 | pubmed:dateCreated | 2007-12-26 | lld:pubmed |
| pubmed-article:18081038 | pubmed:abstractText | The inhibitory effect of DAP12 on macrophages has been revealed by examining myeloid cells from DAP12-deficient mice. In this report, we demonstrate that both DAP12 and the FcepsilonRIgamma-chain (FcRgamma) are required for negative regulation of TLR responses in bone marrow-derived dendritic cells (DC). Loss of both DAP12 and FcRgamma enhanced the pro-inflammatory cytokine production and maturation of DC after TLR stimulation, resulting in a greater percentage of DC that produced IL-12 p40, TNF, and IL-6, and expressed high levels of MHC class II, CD80, and CD86. Whereas DC lacking only DAP12 showed some increased TLR responses, those lacking only FcRgamma had a greater enhancement of maturation and cytokine production, though to a lesser extent than DC lacking both DAP12 and FcRgamma. Additionally, antigen-specific T cell proliferation was enhanced by DAP12(-/-)FcRgamma(-/-) DC relative to wild-type DC after maturation. Similar to DAP12(-/-)FcRgamma(-/-) DC, Syk-deficient DC also had increased inflammatory cytokine production, maturation, and antigen presentation. These results confirm the inhibitory effect of immunoreceptor tyrosine-based activation motif (ITAM) signaling in myeloid cells and show that DC and macrophages differ in their dependence on the ITAM-containing adapters DAP12 and FcRgamma for negative regulation of TLR signaling. | lld:pubmed |
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| pubmed-article:18081038 | pubmed:language | eng | lld:pubmed |
| pubmed-article:18081038 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18081038 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:18081038 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18081038 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:18081038 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18081038 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:18081038 | pubmed:month | Jan | lld:pubmed |
| pubmed-article:18081038 | pubmed:issn | 0014-2980 | lld:pubmed |
| pubmed-article:18081038 | pubmed:author | pubmed-author:LanierLewis... | lld:pubmed |
| pubmed-article:18081038 | pubmed:author | pubmed-author:HamermanJessi... | lld:pubmed |
| pubmed-article:18081038 | pubmed:author | pubmed-author:LowellCliffor... | lld:pubmed |
| pubmed-article:18081038 | pubmed:author | pubmed-author:ChuChing-Lian... | lld:pubmed |
| pubmed-article:18081038 | pubmed:author | pubmed-author:YuYen-LingYL | lld:pubmed |
| pubmed-article:18081038 | pubmed:author | pubmed-author:ShenKuan-YinK... | lld:pubmed |
| pubmed-article:18081038 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:18081038 | pubmed:volume | 38 | lld:pubmed |
| pubmed-article:18081038 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:18081038 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:18081038 | pubmed:pagination | 166-73 | lld:pubmed |
| pubmed-article:18081038 | pubmed:dateRevised | 2011-9-26 | lld:pubmed |
| pubmed-article:18081038 | pubmed:meshHeading | pubmed-meshheading:18081038... | lld:pubmed |
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| pubmed-article:18081038 | pubmed:meshHeading | pubmed-meshheading:18081038... | lld:pubmed |
| pubmed-article:18081038 | pubmed:meshHeading | pubmed-meshheading:18081038... | lld:pubmed |
| pubmed-article:18081038 | pubmed:meshHeading | pubmed-meshheading:18081038... | lld:pubmed |
| pubmed-article:18081038 | pubmed:meshHeading | pubmed-meshheading:18081038... | lld:pubmed |
| pubmed-article:18081038 | pubmed:year | 2008 | lld:pubmed |
| pubmed-article:18081038 | pubmed:articleTitle | Increased TLR responses in dendritic cells lacking the ITAM-containing adapters DAP12 and FcRgamma. | lld:pubmed |
| pubmed-article:18081038 | pubmed:affiliation | Immunology Research Center, National Health Research Institutes, Taiwan. | lld:pubmed |
| pubmed-article:18081038 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:18081038 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
