| pubmed-article:18072722 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:18072722 | lifeskim:mentions | umls-concept:C0022173 | lld:lifeskim |
| pubmed-article:18072722 | lifeskim:mentions | umls-concept:C0033634 | lld:lifeskim |
| pubmed-article:18072722 | lifeskim:mentions | umls-concept:C0220781 | lld:lifeskim |
| pubmed-article:18072722 | lifeskim:mentions | umls-concept:C0220825 | lld:lifeskim |
| pubmed-article:18072722 | lifeskim:mentions | umls-concept:C1883254 | lld:lifeskim |
| pubmed-article:18072722 | lifeskim:mentions | umls-concept:C0936012 | lld:lifeskim |
| pubmed-article:18072722 | lifeskim:mentions | umls-concept:C0679622 | lld:lifeskim |
| pubmed-article:18072722 | lifeskim:mentions | umls-concept:C0205314 | lld:lifeskim |
| pubmed-article:18072722 | lifeskim:mentions | umls-concept:C0205460 | lld:lifeskim |
| pubmed-article:18072722 | lifeskim:mentions | umls-concept:C2351629 | lld:lifeskim |
| pubmed-article:18072722 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:18072722 | pubmed:dateCreated | 2008-1-3 | lld:pubmed |
| pubmed-article:18072722 | pubmed:abstractText | Conventional and novel protein kinase C (PKC) isozymes are the main targets of tumor promoters. We developed 1-hexylindolactam-V10 ( 5) as a selective activator for novel PKC isozymes that play important roles in various cellular processes related to tumor promotion, ischemia--reperfusion injury in the heart, and Alzheimer's disease. The compound existed as a mixture of three conformers. The trans-amide restricted analogues of 5 ( 14 and 15) hardly bound to PKC isozymes, suggesting that the active conformation of 5 could be that with a cis-amide. Compound 5 selectively translocated novel PKC isozymes over conventional PKC isozymes in HeLa cells at 0.1-1 microM. These results suggest that 5 could be useful for the functional analysis of novel PKC isozymes. | lld:pubmed |
| pubmed-article:18072722 | pubmed:language | eng | lld:pubmed |
| pubmed-article:18072722 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18072722 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:18072722 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18072722 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18072722 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18072722 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18072722 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18072722 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18072722 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:18072722 | pubmed:month | Jan | lld:pubmed |
| pubmed-article:18072722 | pubmed:issn | 0022-2623 | lld:pubmed |
| pubmed-article:18072722 | pubmed:author | pubmed-author:SaitoNaoakiN | lld:pubmed |
| pubmed-article:18072722 | pubmed:author | pubmed-author:KashiwagiKaor... | lld:pubmed |
| pubmed-article:18072722 | pubmed:author | pubmed-author:IrieKazuhiroK | lld:pubmed |
| pubmed-article:18072722 | pubmed:author | pubmed-author:NakagawaYuY | lld:pubmed |
| pubmed-article:18072722 | pubmed:author | pubmed-author:YamanakaNobuh... | lld:pubmed |
| pubmed-article:18072722 | pubmed:author | pubmed-author:YanagitaRyo... | lld:pubmed |
| pubmed-article:18072722 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:18072722 | pubmed:day | 10 | lld:pubmed |
| pubmed-article:18072722 | pubmed:volume | 51 | lld:pubmed |
| pubmed-article:18072722 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:18072722 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:18072722 | pubmed:pagination | 46-56 | lld:pubmed |
| pubmed-article:18072722 | pubmed:meshHeading | pubmed-meshheading:18072722... | lld:pubmed |
| pubmed-article:18072722 | pubmed:meshHeading | pubmed-meshheading:18072722... | lld:pubmed |
| pubmed-article:18072722 | pubmed:meshHeading | pubmed-meshheading:18072722... | lld:pubmed |
| pubmed-article:18072722 | pubmed:meshHeading | pubmed-meshheading:18072722... | lld:pubmed |
| pubmed-article:18072722 | pubmed:meshHeading | pubmed-meshheading:18072722... | lld:pubmed |
| pubmed-article:18072722 | pubmed:meshHeading | pubmed-meshheading:18072722... | lld:pubmed |
| pubmed-article:18072722 | pubmed:meshHeading | pubmed-meshheading:18072722... | lld:pubmed |
| pubmed-article:18072722 | pubmed:meshHeading | pubmed-meshheading:18072722... | lld:pubmed |
| pubmed-article:18072722 | pubmed:meshHeading | pubmed-meshheading:18072722... | lld:pubmed |
| pubmed-article:18072722 | pubmed:meshHeading | pubmed-meshheading:18072722... | lld:pubmed |
| pubmed-article:18072722 | pubmed:meshHeading | pubmed-meshheading:18072722... | lld:pubmed |
| pubmed-article:18072722 | pubmed:meshHeading | pubmed-meshheading:18072722... | lld:pubmed |
| pubmed-article:18072722 | pubmed:meshHeading | pubmed-meshheading:18072722... | lld:pubmed |
| pubmed-article:18072722 | pubmed:meshHeading | pubmed-meshheading:18072722... | lld:pubmed |
| pubmed-article:18072722 | pubmed:year | 2008 | lld:pubmed |
| pubmed-article:18072722 | pubmed:articleTitle | Synthesis, conformational analysis, and biological evaluation of 1-hexylindolactam-V10 as a selective activator for novel protein kinase C isozymes. | lld:pubmed |
| pubmed-article:18072722 | pubmed:affiliation | Division of Food Science and Biotechnology, Graduate School of Agriculture, Kyoto University, Kyoto 606-8502, Japan. | lld:pubmed |
| pubmed-article:18072722 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:18072722 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | http://linkedlifedata.com/r... | pubmed-article:18072722 | lld:chembl |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:18072722 | lld:pubmed |
