| pubmed-article:18055696 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:18055696 | lifeskim:mentions | umls-concept:C0001811 | lld:lifeskim |
| pubmed-article:18055696 | lifeskim:mentions | umls-concept:C0079904 | lld:lifeskim |
| pubmed-article:18055696 | lifeskim:mentions | umls-concept:C0441655 | lld:lifeskim |
| pubmed-article:18055696 | lifeskim:mentions | umls-concept:C1514562 | lld:lifeskim |
| pubmed-article:18055696 | lifeskim:mentions | umls-concept:C0024779 | lld:lifeskim |
| pubmed-article:18055696 | lifeskim:mentions | umls-concept:C1709061 | lld:lifeskim |
| pubmed-article:18055696 | pubmed:issue | 24 | lld:pubmed |
| pubmed-article:18055696 | pubmed:dateCreated | 2007-12-14 | lld:pubmed |
| pubmed-article:18055696 | pubmed:databankReference | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18055696 | pubmed:abstractText | Aging is characterized by specific alterations in gene expression, but their underlying mechanisms and functional consequences are not well understood. Here we develop a systematic approach to identify combinatorial cis-regulatory motifs that drive age-dependent gene expression across different tissues and organisms. Integrated analysis of 365 microarrays spanning nine tissue types predicted fourteen motifs as major regulators of age-dependent gene expression in human and mouse. The motif most strongly associated with aging was that of the transcription factor NF-kappaB. Inducible genetic blockade of NF-kappaB for 2 wk in the epidermis of chronologically aged mice reverted the tissue characteristics and global gene expression programs to those of young mice. Age-specific NF-kappaB blockade and orthogonal cell cycle interventions revealed that NF-kappaB controls cell cycle exit and gene expression signature of aging in parallel but not sequential pathways. These results identify a conserved network of regulatory pathways underlying mammalian aging and show that NF-kappaB is continually required to enforce many features of aging in a tissue-specific manner. | lld:pubmed |
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| pubmed-article:18055696 | pubmed:language | eng | lld:pubmed |
| pubmed-article:18055696 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18055696 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:18055696 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18055696 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:18055696 | pubmed:month | Dec | lld:pubmed |
| pubmed-article:18055696 | pubmed:issn | 0890-9369 | lld:pubmed |
| pubmed-article:18055696 | pubmed:author | pubmed-author:SinhaSaurabhS | lld:pubmed |
| pubmed-article:18055696 | pubmed:author | pubmed-author:SegalEranE | lld:pubmed |
| pubmed-article:18055696 | pubmed:author | pubmed-author:ChangHoward... | lld:pubmed |
| pubmed-article:18055696 | pubmed:author | pubmed-author:ZhangJennifer... | lld:pubmed |
| pubmed-article:18055696 | pubmed:author | pubmed-author:AdlerAdam SAS | lld:pubmed |
| pubmed-article:18055696 | pubmed:author | pubmed-author:KawaharaTiara... | lld:pubmed |
| pubmed-article:18055696 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:18055696 | pubmed:day | 15 | lld:pubmed |
| pubmed-article:18055696 | pubmed:volume | 21 | lld:pubmed |
| pubmed-article:18055696 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:18055696 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:18055696 | pubmed:pagination | 3244-57 | lld:pubmed |
| pubmed-article:18055696 | pubmed:dateRevised | 2011-3-29 | lld:pubmed |
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| pubmed-article:18055696 | pubmed:year | 2007 | lld:pubmed |
| pubmed-article:18055696 | pubmed:articleTitle | Motif module map reveals enforcement of aging by continual NF-kappaB activity. | lld:pubmed |
| pubmed-article:18055696 | pubmed:affiliation | Program in Epithelial Biology and Cancer Biology Program, Stanford University School of Medicine, Stanford, California 94305, USA. | lld:pubmed |
| pubmed-article:18055696 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:18055696 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| pubmed-article:18055696 | pubmed:publicationType | Research Support, N.I.H., Extramural | lld:pubmed |
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