Statements in which the resource exists.
SubjectPredicateObjectContext
pubmed-article:18052916rdf:typepubmed:Citationlld:pubmed
pubmed-article:18052916lifeskim:mentionsumls-concept:C0024530lld:lifeskim
pubmed-article:18052916lifeskim:mentionsumls-concept:C0008059lld:lifeskim
pubmed-article:18052916lifeskim:mentionsumls-concept:C0679138lld:lifeskim
pubmed-article:18052916lifeskim:mentionsumls-concept:C0750572lld:lifeskim
pubmed-article:18052916lifeskim:mentionsumls-concept:C0018591lld:lifeskim
pubmed-article:18052916lifeskim:mentionsumls-concept:C2911648lld:lifeskim
pubmed-article:18052916lifeskim:mentionsumls-concept:C0439603lld:lifeskim
pubmed-article:18052916lifeskim:mentionsumls-concept:C0449445lld:lifeskim
pubmed-article:18052916lifeskim:mentionsumls-concept:C1719797lld:lifeskim
pubmed-article:18052916pubmed:dateCreated2007-12-6lld:pubmed
pubmed-article:18052916pubmed:abstractTextCharacterizing genetic variability in the human pathogenic Plasmodium species, the group of parasites that cause Malaria, may have broad global health implications. Specifically, discerning the combinations of mutations that lead to viable parasites and the population level frequencies of these clonal sequences will allow for targeted vaccine development and individualized treatment choices. This presents an analytical challenge, however, since haplotypic phase (i.e. the alignment of bases on a single DNA strand) is generally unobservable in multiply infected individuals. This manuscript describes an expectation maximization (EM) approach to maximum likelihood estimation of haplotype frequencies in this missing data setting. The approach is applied to a cohort of N=341 malaria infected children in Uganda, Cameroon and Sudan to characterize regional differences. A simulation study is also presented to characterize method performance and assess sensitivity to distributional assumptions.lld:pubmed
pubmed-article:18052916pubmed:granthttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:18052916pubmed:granthttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:18052916pubmed:languageenglld:pubmed
pubmed-article:18052916pubmed:journalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:18052916pubmed:citationSubsetIMlld:pubmed
pubmed-article:18052916pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:18052916pubmed:statusMEDLINElld:pubmed
pubmed-article:18052916pubmed:issn1544-6115lld:pubmed
pubmed-article:18052916pubmed:authorpubmed-author:RichStephen...lld:pubmed
pubmed-article:18052916pubmed:authorpubmed-author:LiXiaohongXlld:pubmed
pubmed-article:18052916pubmed:authorpubmed-author:FoulkesAndrea...lld:pubmed
pubmed-article:18052916pubmed:authorpubmed-author:YucelRecai...lld:pubmed
pubmed-article:18052916pubmed:issnTypeElectroniclld:pubmed
pubmed-article:18052916pubmed:volume6lld:pubmed
pubmed-article:18052916pubmed:ownerNLMlld:pubmed
pubmed-article:18052916pubmed:authorsCompleteYlld:pubmed
pubmed-article:18052916pubmed:paginationArticle33lld:pubmed
pubmed-article:18052916pubmed:meshHeadingpubmed-meshheading:18052916...lld:pubmed
pubmed-article:18052916pubmed:meshHeadingpubmed-meshheading:18052916...lld:pubmed
pubmed-article:18052916pubmed:meshHeadingpubmed-meshheading:18052916...lld:pubmed
pubmed-article:18052916pubmed:meshHeadingpubmed-meshheading:18052916...lld:pubmed
pubmed-article:18052916pubmed:meshHeadingpubmed-meshheading:18052916...lld:pubmed
pubmed-article:18052916pubmed:meshHeadingpubmed-meshheading:18052916...lld:pubmed
pubmed-article:18052916pubmed:meshHeadingpubmed-meshheading:18052916...lld:pubmed
pubmed-article:18052916pubmed:meshHeadingpubmed-meshheading:18052916...lld:pubmed
pubmed-article:18052916pubmed:meshHeadingpubmed-meshheading:18052916...lld:pubmed
pubmed-article:18052916pubmed:meshHeadingpubmed-meshheading:18052916...lld:pubmed
pubmed-article:18052916pubmed:year2007lld:pubmed
pubmed-article:18052916pubmed:articleTitleAn expectation maximization approach to estimate malaria haplotype frequencies in multiply infected children.lld:pubmed
pubmed-article:18052916pubmed:affiliationUniversity of Massachusetts, Amherst, MA, USA. xiaohong@schoolph.umass.edulld:pubmed
pubmed-article:18052916pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:18052916pubmed:publicationTypeResearch Support, Non-U.S. Gov'tlld:pubmed
pubmed-article:18052916pubmed:publicationTypeResearch Support, N.I.H., Extramurallld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:18052916lld:pubmed