| pubmed-article:18045856 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:18045856 | lifeskim:mentions | umls-concept:C0034193 | lld:lifeskim |
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| pubmed-article:18045856 | lifeskim:mentions | umls-concept:C0178719 | lld:lifeskim |
| pubmed-article:18045856 | lifeskim:mentions | umls-concept:C0070876 | lld:lifeskim |
| pubmed-article:18045856 | lifeskim:mentions | umls-concept:C1150537 | lld:lifeskim |
| pubmed-article:18045856 | lifeskim:mentions | umls-concept:C0441655 | lld:lifeskim |
| pubmed-article:18045856 | lifeskim:mentions | umls-concept:C1704632 | lld:lifeskim |
| pubmed-article:18045856 | lifeskim:mentions | umls-concept:C0678544 | lld:lifeskim |
| pubmed-article:18045856 | lifeskim:mentions | umls-concept:C0871261 | lld:lifeskim |
| pubmed-article:18045856 | lifeskim:mentions | umls-concept:C0442805 | lld:lifeskim |
| pubmed-article:18045856 | lifeskim:mentions | umls-concept:C2911692 | lld:lifeskim |
| pubmed-article:18045856 | lifeskim:mentions | umls-concept:C1706817 | lld:lifeskim |
| pubmed-article:18045856 | lifeskim:mentions | umls-concept:C0596235 | lld:lifeskim |
| pubmed-article:18045856 | lifeskim:mentions | umls-concept:C0591833 | lld:lifeskim |
| pubmed-article:18045856 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:18045856 | pubmed:dateCreated | 2008-2-15 | lld:pubmed |
| pubmed-article:18045856 | pubmed:abstractText | Phospholamban (PLB) inhibits the sarcoplasmic reticulum (SR) Ca(2+)-ATPase (SERCA), and this inhibition is relieved by Ca(2+) calmodulin-dependent protein kinase II (CaM kinase II) phosphorylation. We previously reported significant differences in contractility, SR Ca(2+) release, and CaM kinase II activity in gastric fundus smooth muscles as a result of PLB phosphorylation by CaM kinase II. In this study, we used PLB-knockout (PLB-KO) mice to directly examine the effect of PLB absence on contractility, CaM kinase II activity, and intracellular Ca(2+) waves in gastric antrum smooth muscles. The frequencies and amplitudes of spontaneous phasic contractions were elevated in antrum smooth muscle strips from PLB-KO mice. Bethanecol increased the amplitudes of phasic contractions in antrum smooth muscles from both control and PLB-KO mice. Caffeine decreased and cyclopiazonic acid (CPA) increased the basal tone of antrum smooth muscle strips from PLB-KO mice, but the effects were less pronounced compared with control strips. The CaM kinase II inhibitor KN-93 was less effective at inhibiting caffeine-induced relaxation in antrum smooth muscle strips from PLB-KO mice. CaM kinase II autonomous activity was elevated, and not further increased by caffeine, in antrum smooth muscles from PLB-KO mice. Similarly, the intracellular Ca(2+) wave frequency was elevated, and not further increased by caffeine, in antrum smooth muscles from PLB-KO mice. These findings suggest that PLB is an important modulator of gastric antrum smooth muscle contractility by modulation of SR Ca(2+) release and CaM kinase II activity. | lld:pubmed |
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| pubmed-article:18045856 | pubmed:language | eng | lld:pubmed |
| pubmed-article:18045856 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18045856 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:18045856 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:18045856 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:18045856 | pubmed:month | Feb | lld:pubmed |
| pubmed-article:18045856 | pubmed:issn | 0363-6143 | lld:pubmed |
| pubmed-article:18045856 | pubmed:author | pubmed-author:HennigGrant... | lld:pubmed |
| pubmed-article:18045856 | pubmed:author | pubmed-author:SmithTerence... | lld:pubmed |
| pubmed-article:18045856 | pubmed:author | pubmed-author:PerrinoBrian... | lld:pubmed |
| pubmed-article:18045856 | pubmed:author | pubmed-author:KimMinkyungM | lld:pubmed |
| pubmed-article:18045856 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:18045856 | pubmed:volume | 294 | lld:pubmed |
| pubmed-article:18045856 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:18045856 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:18045856 | pubmed:pagination | C432-41 | lld:pubmed |
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| pubmed-article:18045856 | pubmed:year | 2008 | lld:pubmed |
| pubmed-article:18045856 | pubmed:articleTitle | Phospholamban knockout increases CaM kinase II activity and intracellular Ca2+ wave activity and alters contractile responses of murine gastric antrum. | lld:pubmed |
| pubmed-article:18045856 | pubmed:affiliation | Department of Physiology and Cell Biology, University of Nevada School of Medicine, Reno, NV 89557, USA. | lld:pubmed |
| pubmed-article:18045856 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:18045856 | pubmed:publicationType | Research Support, N.I.H., Extramural | lld:pubmed |
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