Linked Life Data

18027867

Source:http://linkedlifedata.com/resource/pubmed/id/18027867

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pubmed-article:18027867pubmed:abstractTextIn this paper we characterize hPARM-1, the human ortholog of rat PARM-1 (prostatic androgen-repressed message-1) and demonstrate its role in prostate cancer. Immunofluorescence microscopy and ultrastructural analysis revealed the localization of hPARM-1 to Golgi, plasma membrane and the early endocytic pathway but not in lysosomes. Biochemical and deglycosylation studies showed hPARM-1 as a highly glycosylated, mucin-like type I transmembrane protein. Analysis of expression of hPARM-1 in various human tissues revealed its presence in most human tissues with especially high expression in heart, kidney and placenta. Androgen controls the expression of the gene as a marked 7-fold increase is seen in the androgen-dependent prostate cancer cell line, LNCaP on androgen stimulation. This is further supported by its decrease in expression in CWR22 xenograft upon castration. Moreover, ectopic expression of hPARM-1 in PC3 prostate cancer cells increased colony formation, suggesting a probable role in cell proliferation. These results suggest that hPARM-1 may have a role in normal biology of the prostate cell and in prostate cancer.lld:pubmed
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pubmed-article:18027867pubmed:copyrightInfo(c) 2007 Wiley-Liss, Inc.lld:pubmed
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pubmed-article:18027867pubmed:articleTitleHuman PARM-1 is a novel mucin-like, androgen-regulated gene exhibiting proliferative effects in prostate cancer cells.lld:pubmed
pubmed-article:18027867pubmed:affiliationDepartment of Molecular Biosciences, University of Oslo, Oslo, Norway.lld:pubmed
pubmed-article:18027867pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:18027867pubmed:publicationTypeResearch Support, Non-U.S. Gov'tlld:pubmed
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