| pubmed-article:18023370 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:18023370 | lifeskim:mentions | umls-concept:C0007634 | lld:lifeskim |
| pubmed-article:18023370 | lifeskim:mentions | umls-concept:C1332717 | lld:lifeskim |
| pubmed-article:18023370 | lifeskim:mentions | umls-concept:C1706438 | lld:lifeskim |
| pubmed-article:18023370 | lifeskim:mentions | umls-concept:C0003320 | lld:lifeskim |
| pubmed-article:18023370 | lifeskim:mentions | umls-concept:C0085358 | lld:lifeskim |
| pubmed-article:18023370 | lifeskim:mentions | umls-concept:C0024518 | lld:lifeskim |
| pubmed-article:18023370 | lifeskim:mentions | umls-concept:C1332714 | lld:lifeskim |
| pubmed-article:18023370 | lifeskim:mentions | umls-concept:C1442161 | lld:lifeskim |
| pubmed-article:18023370 | lifeskim:mentions | umls-concept:C1413244 | lld:lifeskim |
| pubmed-article:18023370 | lifeskim:mentions | umls-concept:C2698600 | lld:lifeskim |
| pubmed-article:18023370 | lifeskim:mentions | umls-concept:C0023636 | lld:lifeskim |
| pubmed-article:18023370 | lifeskim:mentions | umls-concept:C0079411 | lld:lifeskim |
| pubmed-article:18023370 | pubmed:issue | 5 | lld:pubmed |
| pubmed-article:18023370 | pubmed:dateCreated | 2007-11-22 | lld:pubmed |
| pubmed-article:18023370 | pubmed:abstractText | The thymus generates major histocompatibility complex (MHC)-restricted alphabetaT cells that only recognize antigenic ligands in association with MHC or MHC-like molecules. We hypothesized that MHC specificity might be imposed on a broader alphabetaTCR repertoire during thymic selection by CD4 and CD8 coreceptors that bind and effectively sequester the tyrosine kinase Lck, thereby preventing T cell receptor (TCR) signaling by non-MHC ligands that do not engage either coreceptor. This hypothesis predicts that, in coreceptor-deficient mice, alphabeta thymocytes would be signaled by non-MHC ligands to differentiate into alphabetaT cells lacking MHC specificity. We now report that MHC-independent alphabetaT cells were indeed generated in mice deficient in both coreceptors as well as MHC ("quad-deficient" mice) and that such mice contained a diverse alphabetaT cell repertoire whose MHC independence was confirmed at the clonal level. We conclude that CD4 and CD8 coreceptors impose MHC specificity on a broader alphabetaTCR repertoire during thymic selection by preventing thymocytes from being signaled by non-MHC ligands. | lld:pubmed |
| pubmed-article:18023370 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18023370 | pubmed:language | eng | lld:pubmed |
| pubmed-article:18023370 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18023370 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:18023370 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:18023370 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:18023370 | pubmed:month | Nov | lld:pubmed |
| pubmed-article:18023370 | pubmed:issn | 1074-7613 | lld:pubmed |
| pubmed-article:18023370 | pubmed:author | pubmed-author:SingerAlfredA | lld:pubmed |
| pubmed-article:18023370 | pubmed:author | pubmed-author:SharrowSusan... | lld:pubmed |
| pubmed-article:18023370 | pubmed:author | pubmed-author:FeigenbaumLio... | lld:pubmed |
| pubmed-article:18023370 | pubmed:author | pubmed-author:ParkJung-Hyun... | lld:pubmed |
| pubmed-article:18023370 | pubmed:author | pubmed-author:TaiXuguangX | lld:pubmed |
| pubmed-article:18023370 | pubmed:author | pubmed-author:AdamsAnthonyA | lld:pubmed |
| pubmed-article:18023370 | pubmed:author | pubmed-author:Van... | lld:pubmed |
| pubmed-article:18023370 | pubmed:author | pubmed-author:GuinterTerry... | lld:pubmed |
| pubmed-article:18023370 | pubmed:author | pubmed-author:SarafovaSophi... | lld:pubmed |
| pubmed-article:18023370 | pubmed:author | pubmed-author:AdoroStanleyS | lld:pubmed |
| pubmed-article:18023370 | pubmed:author | pubmed-author:PobezinskyLeo... | lld:pubmed |
| pubmed-article:18023370 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:18023370 | pubmed:volume | 27 | lld:pubmed |
| pubmed-article:18023370 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:18023370 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:18023370 | pubmed:pagination | 735-50 | lld:pubmed |
| pubmed-article:18023370 | pubmed:dateRevised | 2009-11-19 | lld:pubmed |
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| pubmed-article:18023370 | pubmed:meshHeading | pubmed-meshheading:18023370... | lld:pubmed |
| pubmed-article:18023370 | pubmed:year | 2007 | lld:pubmed |
| pubmed-article:18023370 | pubmed:articleTitle | Deletion of CD4 and CD8 coreceptors permits generation of alphabetaT cells that recognize antigens independently of the MHC. | lld:pubmed |
| pubmed-article:18023370 | pubmed:affiliation | Experimental Immunology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA. | lld:pubmed |
| pubmed-article:18023370 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:18023370 | pubmed:publicationType | Research Support, N.I.H., Intramural | lld:pubmed |
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