| pubmed-article:17989707 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:17989707 | lifeskim:mentions | umls-concept:C0024109 | lld:lifeskim |
| pubmed-article:17989707 | lifeskim:mentions | umls-concept:C0026336 | lld:lifeskim |
| pubmed-article:17989707 | lifeskim:mentions | umls-concept:C0021853 | lld:lifeskim |
| pubmed-article:17989707 | lifeskim:mentions | umls-concept:C0023884 | lld:lifeskim |
| pubmed-article:17989707 | lifeskim:mentions | umls-concept:C0039198 | lld:lifeskim |
| pubmed-article:17989707 | lifeskim:mentions | umls-concept:C0856825 | lld:lifeskim |
| pubmed-article:17989707 | lifeskim:mentions | umls-concept:C1527144 | lld:lifeskim |
| pubmed-article:17989707 | lifeskim:mentions | umls-concept:C0591833 | lld:lifeskim |
| pubmed-article:17989707 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:17989707 | pubmed:dateCreated | 2008-1-22 | lld:pubmed |
| pubmed-article:17989707 | pubmed:abstractText | Adoptive transfer of CD4+CD25+ regulatory T cells has been shown to have therapeutic effects in experimental graft-vs-host disease (GVHD) models. Chemokines play an important role in the recruitment of alloreactive donor T cells into target organs during GVHD. In this study, we investigated the effectiveness of targeted delivery of CD4+CD25+ regulatory T cells via a transfected chemokine receptor on reduction of organ damage during acute GVHD. High levels of expression of Th1-associated chemokines (CXCL9, CXCL10 and CXCL11) and their receptor CXCR3 were observed in the liver, lung and intestine of GVHD-induced recipient mice. Recipient mice that had undergone transfer of CD4+CD25+Foxp3+ CXCR3-transfected T cells (CXCR3-Treg cells) showed significant amelioration of GVHD changes in the liver, lung and intestine in comparison with recipient mice that had received CD4+CD25+Foxp3+ T cells (Treg cells) or naturally occurring CD4+CD25+ regulatory T cells. This was due to more pronounced migration of CXCR3-Treg cells and their localization for a longer time in Th1-associated chemokine-expressing organs, resulting in stronger suppressive activity. We succeeded in preparing chemokine receptor-expressing Treg cells and demonstrated their ability to ameliorate disease progression upon accumulation in target organs. This method may provide a new therapeutic approach for organ damage in acute GVHD. | lld:pubmed |
| pubmed-article:17989707 | pubmed:language | eng | lld:pubmed |
| pubmed-article:17989707 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17989707 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:17989707 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17989707 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17989707 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17989707 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:17989707 | pubmed:month | Feb | lld:pubmed |
| pubmed-article:17989707 | pubmed:issn | 1476-5462 | lld:pubmed |
| pubmed-article:17989707 | pubmed:author | pubmed-author:LeuFF | lld:pubmed |
| pubmed-article:17989707 | pubmed:author | pubmed-author:MOENH MHM | lld:pubmed |
| pubmed-article:17989707 | pubmed:author | pubmed-author:KohnoMM | lld:pubmed |
| pubmed-article:17989707 | pubmed:author | pubmed-author:MiyazakiTT | lld:pubmed |
| pubmed-article:17989707 | pubmed:author | pubmed-author:HasegawaHH | lld:pubmed |
| pubmed-article:17989707 | pubmed:author | pubmed-author:InoueAA | lld:pubmed |
| pubmed-article:17989707 | pubmed:author | pubmed-author:YasukawaMM | lld:pubmed |
| pubmed-article:17989707 | pubmed:author | pubmed-author:YoshiiCC | lld:pubmed |
| pubmed-article:17989707 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:17989707 | pubmed:volume | 15 | lld:pubmed |
| pubmed-article:17989707 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:17989707 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:17989707 | pubmed:pagination | 171-82 | lld:pubmed |
| pubmed-article:17989707 | pubmed:meshHeading | pubmed-meshheading:17989707... | lld:pubmed |
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| pubmed-article:17989707 | pubmed:meshHeading | pubmed-meshheading:17989707... | lld:pubmed |
| pubmed-article:17989707 | pubmed:year | 2008 | lld:pubmed |
| pubmed-article:17989707 | pubmed:articleTitle | Therapeutic effect of CXCR3-expressing regulatory T cells on liver, lung and intestinal damages in a murine acute GVHD model. | lld:pubmed |
| pubmed-article:17989707 | pubmed:affiliation | Department of Bioregulatory Medicine, Ehime University Graduate School of Medicine, Ehime, Japan. hitoshih@m.ehime-u.ac.jp | lld:pubmed |
| pubmed-article:17989707 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:17989707 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:17989707 | lld:pubmed |
