Linked Life Data

17982081

Source:http://linkedlifedata.com/resource/pubmed/id/17982081

Statements in which the resource exists.
SubjectPredicateObjectContext
pubmed-article:17982081rdf:typepubmed:Citationlld:pubmed
pubmed-article:17982081lifeskim:mentionsumls-concept:C0242632lld:lifeskim
pubmed-article:17982081lifeskim:mentionsumls-concept:C0011306lld:lifeskim
pubmed-article:17982081lifeskim:mentionsumls-concept:C0023693lld:lifeskim
pubmed-article:17982081lifeskim:mentionsumls-concept:C1704632lld:lifeskim
pubmed-article:17982081lifeskim:mentionsumls-concept:C0871261lld:lifeskim
pubmed-article:17982081lifeskim:mentionsumls-concept:C1332714lld:lifeskim
pubmed-article:17982081lifeskim:mentionsumls-concept:C1420817lld:lifeskim
pubmed-article:17982081lifeskim:mentionsumls-concept:C2911692lld:lifeskim
pubmed-article:17982081lifeskim:mentionsumls-concept:C1706817lld:lifeskim
pubmed-article:17982081lifeskim:mentionsumls-concept:C1819439lld:lifeskim
pubmed-article:17982081lifeskim:mentionsumls-concept:C0683598lld:lifeskim
pubmed-article:17982081lifeskim:mentionsumls-concept:C0023276lld:lifeskim
pubmed-article:17982081lifeskim:mentionsumls-concept:C1511545lld:lifeskim
pubmed-article:17982081lifeskim:mentionsumls-concept:C2698651lld:lifeskim
pubmed-article:17982081pubmed:issue10lld:pubmed
pubmed-article:17982081pubmed:dateCreated2007-11-5lld:pubmed
pubmed-article:17982081pubmed:abstractTextAlthough studies indicate LIGHT (lymphotoxin (LT)-like, exhibits inducible expression and competes with HSV glycoprotein D for herpes virus entry mediator (HVEM), a receptor expressed by T lymphocytes) enhances inflammation and T cell-mediated immunity, the mechanisms involved in this process remain obscure. In this study, we assessed the role of LIGHT in IL-12 production and development of CD4(+) Th cells type one (Th1) in vivo. Bone marrow-derived dendritic cells from LIGHT(-/-) mice were severely impaired in IL-12p40 production following IFN-gamma and LPS stimulation in vitro. Furthermore, blockade of LIGHT in vitro and in vivo with HVEM-Ig and LT beta receptor (LTbetaR)-Ig leads to impaired IL-12 production and defective polyclonal and Ag-specific IFN-gamma production in vivo. In an infection model, injection of HVEM-Ig or LTbetaR-Ig into the usually resistant C57BL/6 mice results in defective IL-12 and IFN-gamma production and severe susceptibility to Leishmania major that was reversed by rIL-12 treatment. This striking susceptibility to L. major in mice injected with HVEM-Ig or LTbetaR-Ig was also reproduced in LIGHT(-/-) --> RAG1(-/-) chimeric mice. In contrast, L. major-infected LTbeta(-/-) mice do not develop acute disease, suggesting that the effect of LTbetaR-Ig is not due to blockade of membrane LT (LTalpha1beta2) signaling. Collectively, our data show that LIGHT plays a critical role for optimal IL-12 production by DC and the development of IFN-gamma-producing CD4(+) Th1 cells and its blockade results in severe susceptibility to Leishmania major.lld:pubmed
pubmed-article:17982081pubmed:languageenglld:pubmed
pubmed-article:17982081pubmed:journalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:17982081pubmed:citationSubsetAIMlld:pubmed
pubmed-article:17982081pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:17982081pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:17982081pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:17982081pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:17982081pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:17982081pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:17982081pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:17982081pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:17982081pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:17982081pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:17982081pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:17982081pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:17982081pubmed:statusMEDLINElld:pubmed
pubmed-article:17982081pubmed:monthNovlld:pubmed
pubmed-article:17982081pubmed:issn0022-1767lld:pubmed
pubmed-article:17982081pubmed:authorpubmed-author:WangYangYlld:pubmed
pubmed-article:17982081pubmed:authorpubmed-author:FuYang-XinYXlld:pubmed
pubmed-article:17982081pubmed:authorpubmed-author:LiuDongDlld:pubmed
pubmed-article:17982081pubmed:authorpubmed-author:XuGuilianGlld:pubmed
pubmed-article:17982081pubmed:authorpubmed-author:UzonnaJude...lld:pubmed
pubmed-article:17982081pubmed:authorpubmed-author:KornerHeinric...lld:pubmed
pubmed-article:17982081pubmed:authorpubmed-author:KungSam K PSKlld:pubmed
pubmed-article:17982081pubmed:authorpubmed-author:OkworIfeomaIlld:pubmed
pubmed-article:17982081pubmed:issnTypePrintlld:pubmed
pubmed-article:17982081pubmed:day15lld:pubmed
pubmed-article:17982081pubmed:volume179lld:pubmed
pubmed-article:17982081pubmed:ownerNLMlld:pubmed
pubmed-article:17982081pubmed:authorsCompleteYlld:pubmed
pubmed-article:17982081pubmed:pagination6901-9lld:pubmed
pubmed-article:17982081pubmed:dateRevised2008-11-21lld:pubmed
pubmed-article:17982081pubmed:meshHeadingpubmed-meshheading:17982081...lld:pubmed
pubmed-article:17982081pubmed:meshHeadingpubmed-meshheading:17982081...lld:pubmed
pubmed-article:17982081pubmed:meshHeadingpubmed-meshheading:17982081...lld:pubmed
pubmed-article:17982081pubmed:meshHeadingpubmed-meshheading:17982081...lld:pubmed
pubmed-article:17982081pubmed:meshHeadingpubmed-meshheading:17982081...lld:pubmed
pubmed-article:17982081pubmed:meshHeadingpubmed-meshheading:17982081...lld:pubmed
pubmed-article:17982081pubmed:meshHeadingpubmed-meshheading:17982081...lld:pubmed
pubmed-article:17982081pubmed:meshHeadingpubmed-meshheading:17982081...lld:pubmed
pubmed-article:17982081pubmed:meshHeadingpubmed-meshheading:17982081...lld:pubmed
pubmed-article:17982081pubmed:meshHeadingpubmed-meshheading:17982081...lld:pubmed
pubmed-article:17982081pubmed:meshHeadingpubmed-meshheading:17982081...lld:pubmed
pubmed-article:17982081pubmed:meshHeadingpubmed-meshheading:17982081...lld:pubmed
pubmed-article:17982081pubmed:meshHeadingpubmed-meshheading:17982081...lld:pubmed
pubmed-article:17982081pubmed:meshHeadingpubmed-meshheading:17982081...lld:pubmed
pubmed-article:17982081pubmed:meshHeadingpubmed-meshheading:17982081...lld:pubmed
pubmed-article:17982081pubmed:meshHeadingpubmed-meshheading:17982081...lld:pubmed
pubmed-article:17982081pubmed:meshHeadingpubmed-meshheading:17982081...lld:pubmed
pubmed-article:17982081pubmed:meshHeadingpubmed-meshheading:17982081...lld:pubmed
pubmed-article:17982081pubmed:meshHeadingpubmed-meshheading:17982081...lld:pubmed
pubmed-article:17982081pubmed:year2007lld:pubmed
pubmed-article:17982081pubmed:articleTitleLIGHT Is critical for IL-12 production by dendritic cells, optimal CD4+ Th1 cell response, and resistance to Leishmania major.lld:pubmed
pubmed-article:17982081pubmed:affiliationDepartment of Immunology, Faculty of Medicine University of Manitoba, Winnipeg, Canada.lld:pubmed
pubmed-article:17982081pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:17982081pubmed:publicationTypeResearch Support, Non-U.S. Gov'tlld:pubmed
entrez-gene:15978entrezgene:pubmedpubmed-article:17982081lld:entrezgene
entrez-gene:16160entrezgene:pubmedpubmed-article:17982081lld:entrezgene
entrez-gene:16994entrezgene:pubmedpubmed-article:17982081lld:entrezgene
entrez-gene:50930entrezgene:pubmedpubmed-article:17982081lld:entrezgene
entrez-gene:230979entrezgene:pubmedpubmed-article:17982081lld:entrezgene
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:17982081lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:17982081lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:17982081lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:17982081lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:17982081lld:pubmed