| pubmed-article:17950003 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:17950003 | lifeskim:mentions | umls-concept:C0042769 | lld:lifeskim |
| pubmed-article:17950003 | lifeskim:mentions | umls-concept:C1332717 | lld:lifeskim |
| pubmed-article:17950003 | lifeskim:mentions | umls-concept:C1706438 | lld:lifeskim |
| pubmed-article:17950003 | lifeskim:mentions | umls-concept:C0039194 | lld:lifeskim |
| pubmed-article:17950003 | lifeskim:mentions | umls-concept:C0085358 | lld:lifeskim |
| pubmed-article:17950003 | lifeskim:mentions | umls-concept:C0392674 | lld:lifeskim |
| pubmed-article:17950003 | lifeskim:mentions | umls-concept:C1413244 | lld:lifeskim |
| pubmed-article:17950003 | lifeskim:mentions | umls-concept:C2698600 | lld:lifeskim |
| pubmed-article:17950003 | lifeskim:mentions | umls-concept:C1704864 | lld:lifeskim |
| pubmed-article:17950003 | lifeskim:mentions | umls-concept:C0205191 | lld:lifeskim |
| pubmed-article:17950003 | pubmed:issue | 4 | lld:pubmed |
| pubmed-article:17950003 | pubmed:dateCreated | 2007-10-30 | lld:pubmed |
| pubmed-article:17950003 | pubmed:databankReference | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17950003 | pubmed:databankReference | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17950003 | pubmed:databankReference | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17950003 | pubmed:databankReference | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17950003 | pubmed:databankReference | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17950003 | pubmed:databankReference | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17950003 | pubmed:databankReference | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17950003 | pubmed:databankReference | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17950003 | pubmed:databankReference | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17950003 | pubmed:databankReference | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17950003 | pubmed:databankReference | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17950003 | pubmed:databankReference | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17950003 | pubmed:databankReference | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17950003 | pubmed:databankReference | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17950003 | pubmed:databankReference | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17950003 | pubmed:abstractText | Chronic viral infections often result in T cell exhaustion. To determine the molecular signature of exhaustion, we compared the gene-expression profiles of dysfunctional lymphocytic choriomeningitis virus (LCMV)-specific CD8(+) T cells from chronic infection to functional LCMV-specific effector and memory CD8(+) T cells generated after acute infection. These data showed that exhausted CD8(+) T cells: (1) overexpressed several inhibitory receptors, including PD-1, (2) had major changes in T cell receptor and cytokine signaling pathways, (3) displayed altered expression of genes involved in chemotaxis, adhesion, and migration, (4) expressed a distinct set of transcription factors, and (5) had profound metabolic and bioenergetic deficiencies. T cell exhaustion was progressive, and gene-expression profiling indicated that T cell exhaustion and anergy were distinct processes. Thus, functional exhaustion is probably due to both active suppression and passive defects in signaling and metabolism. These results provide a framework for designing rational immunotherapies during chronic infections. | lld:pubmed |
| pubmed-article:17950003 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17950003 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17950003 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17950003 | pubmed:language | eng | lld:pubmed |
| pubmed-article:17950003 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17950003 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:17950003 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:17950003 | pubmed:month | Oct | lld:pubmed |
| pubmed-article:17950003 | pubmed:issn | 1074-7613 | lld:pubmed |
| pubmed-article:17950003 | pubmed:author | pubmed-author:BlattmanJosep... | lld:pubmed |
| pubmed-article:17950003 | pubmed:author | pubmed-author:KaechSusan... | lld:pubmed |
| pubmed-article:17950003 | pubmed:author | pubmed-author:AhmedRafiR | lld:pubmed |
| pubmed-article:17950003 | pubmed:author | pubmed-author:WherryE... | lld:pubmed |
| pubmed-article:17950003 | pubmed:author | pubmed-author:SarkarSurojit... | lld:pubmed |
| pubmed-article:17950003 | pubmed:author | pubmed-author:KaliaVandanaV | lld:pubmed |
| pubmed-article:17950003 | pubmed:author | pubmed-author:BarberDaniel... | lld:pubmed |
| pubmed-article:17950003 | pubmed:author | pubmed-author:HaSang-JunSJ | lld:pubmed |
| pubmed-article:17950003 | pubmed:author | pubmed-author:HainingW... | lld:pubmed |
| pubmed-article:17950003 | pubmed:author | pubmed-author:SubramaniamSh... | lld:pubmed |
| pubmed-article:17950003 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:17950003 | pubmed:volume | 27 | lld:pubmed |
| pubmed-article:17950003 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:17950003 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:17950003 | pubmed:pagination | 670-84 | lld:pubmed |
| pubmed-article:17950003 | pubmed:dateRevised | 2007-12-19 | lld:pubmed |
| pubmed-article:17950003 | pubmed:meshHeading | pubmed-meshheading:17950003... | lld:pubmed |
| pubmed-article:17950003 | pubmed:meshHeading | pubmed-meshheading:17950003... | lld:pubmed |
| pubmed-article:17950003 | pubmed:meshHeading | pubmed-meshheading:17950003... | lld:pubmed |
| pubmed-article:17950003 | pubmed:meshHeading | pubmed-meshheading:17950003... | lld:pubmed |
| pubmed-article:17950003 | pubmed:meshHeading | pubmed-meshheading:17950003... | lld:pubmed |
| pubmed-article:17950003 | pubmed:meshHeading | pubmed-meshheading:17950003... | lld:pubmed |
| pubmed-article:17950003 | pubmed:meshHeading | pubmed-meshheading:17950003... | lld:pubmed |
| pubmed-article:17950003 | pubmed:meshHeading | pubmed-meshheading:17950003... | lld:pubmed |
| pubmed-article:17950003 | pubmed:meshHeading | pubmed-meshheading:17950003... | lld:pubmed |
| pubmed-article:17950003 | pubmed:meshHeading | pubmed-meshheading:17950003... | lld:pubmed |
| pubmed-article:17950003 | pubmed:meshHeading | pubmed-meshheading:17950003... | lld:pubmed |
| pubmed-article:17950003 | pubmed:meshHeading | pubmed-meshheading:17950003... | lld:pubmed |
| pubmed-article:17950003 | pubmed:meshHeading | pubmed-meshheading:17950003... | lld:pubmed |
| pubmed-article:17950003 | pubmed:meshHeading | pubmed-meshheading:17950003... | lld:pubmed |
| pubmed-article:17950003 | pubmed:meshHeading | pubmed-meshheading:17950003... | lld:pubmed |
| pubmed-article:17950003 | pubmed:meshHeading | pubmed-meshheading:17950003... | lld:pubmed |
| pubmed-article:17950003 | pubmed:meshHeading | pubmed-meshheading:17950003... | lld:pubmed |
| pubmed-article:17950003 | pubmed:meshHeading | pubmed-meshheading:17950003... | lld:pubmed |
| pubmed-article:17950003 | pubmed:year | 2007 | lld:pubmed |
| pubmed-article:17950003 | pubmed:articleTitle | Molecular signature of CD8+ T cell exhaustion during chronic viral infection. | lld:pubmed |
| pubmed-article:17950003 | pubmed:affiliation | Emory Vaccine Center and Department of Microbiology and Immunology, Emory University School of Medicine, 1510 Clifton Road Room G211, Atlanta, GA 30322, USA. jwherry@wistar.org | lld:pubmed |
| pubmed-article:17950003 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:17950003 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| pubmed-article:17950003 | pubmed:publicationType | Research Support, N.I.H., Extramural | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:17950003 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:17950003 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:17950003 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:17950003 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:17950003 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:17950003 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:17950003 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:17950003 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:17950003 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:17950003 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:17950003 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:17950003 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:17950003 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:17950003 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:17950003 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:17950003 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:17950003 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:17950003 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:17950003 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:17950003 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:17950003 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:17950003 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:17950003 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:17950003 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:17950003 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:17950003 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:17950003 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:17950003 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:17950003 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:17950003 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:17950003 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:17950003 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:17950003 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:17950003 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:17950003 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:17950003 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:17950003 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:17950003 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:17950003 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:17950003 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:17950003 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:17950003 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:17950003 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:17950003 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:17950003 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:17950003 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:17950003 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:17950003 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:17950003 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:17950003 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:17950003 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:17950003 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:17950003 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:17950003 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:17950003 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:17950003 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:17950003 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:17950003 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:17950003 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:17950003 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:17950003 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:17950003 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:17950003 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:17950003 | lld:pubmed |
