| pubmed-article:17948050 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:17948050 | lifeskim:mentions | umls-concept:C1155065 | lld:lifeskim |
| pubmed-article:17948050 | lifeskim:mentions | umls-concept:C0037083 | lld:lifeskim |
| pubmed-article:17948050 | lifeskim:mentions | umls-concept:C0079904 | lld:lifeskim |
| pubmed-article:17948050 | lifeskim:mentions | umls-concept:C1519751 | lld:lifeskim |
| pubmed-article:17948050 | lifeskim:mentions | umls-concept:C1416991 | lld:lifeskim |
| pubmed-article:17948050 | lifeskim:mentions | umls-concept:C1710082 | lld:lifeskim |
| pubmed-article:17948050 | lifeskim:mentions | umls-concept:C1444748 | lld:lifeskim |
| pubmed-article:17948050 | pubmed:issue | 22 | lld:pubmed |
| pubmed-article:17948050 | pubmed:dateCreated | 2007-11-16 | lld:pubmed |
| pubmed-article:17948050 | pubmed:abstractText | Triggering of antigen receptors on lymphocytes is critical for initiating adaptive immune response against pathogens. T-cell receptor (TCR) engagement induces the formation of the Carma1-Bcl10-Malt1 (CBM) complex that is essential for activation of the IkappaB kinase (IKK)/NF-kappaB pathway. However, the molecular mechanisms that link CBM complex formation to IKK activation remain unclear. Here we report that Malt1 is polyubiquitinated upon T-cell activation. Ubiquitin chains on Malt1 provide a docking surface for the recruitment of the IKK regulatory subunit NEMO/IKKgamma. TRAF6 associates with Malt1 in response to T-cell activation and can function as an E3 ligase for Malt1 in vitro and in vivo, mediating lysine 63-linked ubiquitination of Malt1. Multiple lysine residues in the C-terminus of Malt1 serve as acceptor sites for the assembly of polyubiquitin chains. Malt1 mutants that lack C-terminal ubiquitin acceptor lysines are impaired in rescuing NF-kappaB signaling and IL-2 production in Malt1-/- T cells. Thus, our data demonstrate that induced Malt1 ubiquitination is critical for the engagement of CBM and IKK complexes, thereby directing TCR signals to the canonical NF-kappaB pathway. | lld:pubmed |
| pubmed-article:17948050 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17948050 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17948050 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17948050 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17948050 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17948050 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17948050 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17948050 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17948050 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17948050 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17948050 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17948050 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17948050 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17948050 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17948050 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17948050 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17948050 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17948050 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17948050 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17948050 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17948050 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17948050 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17948050 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17948050 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17948050 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17948050 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17948050 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17948050 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17948050 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17948050 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17948050 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17948050 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17948050 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17948050 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17948050 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17948050 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17948050 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17948050 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17948050 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17948050 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17948050 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17948050 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17948050 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17948050 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17948050 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17948050 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17948050 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17948050 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17948050 | pubmed:language | eng | lld:pubmed |
| pubmed-article:17948050 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17948050 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:17948050 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17948050 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17948050 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17948050 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17948050 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17948050 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17948050 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17948050 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17948050 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17948050 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17948050 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17948050 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17948050 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17948050 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:17948050 | pubmed:month | Nov | lld:pubmed |
| pubmed-article:17948050 | pubmed:issn | 1460-2075 | lld:pubmed |
| pubmed-article:17948050 | pubmed:author | pubmed-author:KrappmannDani... | lld:pubmed |
| pubmed-article:17948050 | pubmed:author | pubmed-author:ScheidereitCl... | lld:pubmed |
| pubmed-article:17948050 | pubmed:author | pubmed-author:WegenerElmarE | lld:pubmed |
| pubmed-article:17948050 | pubmed:author | pubmed-author:RulandJürgenJ | lld:pubmed |
| pubmed-article:17948050 | pubmed:author | pubmed-author:OeckinghausAn... | lld:pubmed |
| pubmed-article:17948050 | pubmed:author | pubmed-author:FerchUtaU | lld:pubmed |
| pubmed-article:17948050 | pubmed:author | pubmed-author:ArslanSeda... | lld:pubmed |
| pubmed-article:17948050 | pubmed:author | pubmed-author:WeltekeVerena... | lld:pubmed |
| pubmed-article:17948050 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:17948050 | pubmed:day | 14 | lld:pubmed |
| pubmed-article:17948050 | pubmed:volume | 26 | lld:pubmed |
| pubmed-article:17948050 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:17948050 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:17948050 | pubmed:pagination | 4634-45 | lld:pubmed |
| pubmed-article:17948050 | pubmed:dateRevised | 2009-11-19 | lld:pubmed |
| pubmed-article:17948050 | pubmed:meshHeading | pubmed-meshheading:17948050... | lld:pubmed |
| pubmed-article:17948050 | pubmed:meshHeading | pubmed-meshheading:17948050... | lld:pubmed |
| pubmed-article:17948050 | pubmed:meshHeading | pubmed-meshheading:17948050... | lld:pubmed |
| pubmed-article:17948050 | pubmed:meshHeading | pubmed-meshheading:17948050... | lld:pubmed |
| pubmed-article:17948050 | pubmed:meshHeading | pubmed-meshheading:17948050... | lld:pubmed |
| pubmed-article:17948050 | pubmed:meshHeading | pubmed-meshheading:17948050... | lld:pubmed |
| pubmed-article:17948050 | pubmed:meshHeading | pubmed-meshheading:17948050... | lld:pubmed |
