| pubmed-article:17940204 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:17940204 | lifeskim:mentions | umls-concept:C0023449 | lld:lifeskim |
| pubmed-article:17940204 | lifeskim:mentions | umls-concept:C0040715 | lld:lifeskim |
| pubmed-article:17940204 | lifeskim:mentions | umls-concept:C0034897 | lld:lifeskim |
| pubmed-article:17940204 | lifeskim:mentions | umls-concept:C1522702 | lld:lifeskim |
| pubmed-article:17940204 | lifeskim:mentions | umls-concept:C0017351 | lld:lifeskim |
| pubmed-article:17940204 | lifeskim:mentions | umls-concept:C1415857 | lld:lifeskim |
| pubmed-article:17940204 | lifeskim:mentions | umls-concept:C1538631 | lld:lifeskim |
| pubmed-article:17940204 | lifeskim:mentions | umls-concept:C1825005 | lld:lifeskim |
| pubmed-article:17940204 | lifeskim:mentions | umls-concept:C0599718 | lld:lifeskim |
| pubmed-article:17940204 | lifeskim:mentions | umls-concept:C0599813 | lld:lifeskim |
| pubmed-article:17940204 | lifeskim:mentions | umls-concept:C0599893 | lld:lifeskim |
| pubmed-article:17940204 | lifeskim:mentions | umls-concept:C1314939 | lld:lifeskim |
| pubmed-article:17940204 | lifeskim:mentions | umls-concept:C1709634 | lld:lifeskim |
| pubmed-article:17940204 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:17940204 | pubmed:dateCreated | 2007-12-24 | lld:pubmed |
| pubmed-article:17940204 | pubmed:abstractText | Translocations involving the immunoglobulin heavy chain locus (IGH@) at chromosome band 14q32 are common in mature B-cell neoplasms, but are rare in B-cell precursor acute lymphoblastic leukemia (BCP-ALL). Here, we report the translocation, t(6;14)(p22;q32), involving IGH@ as a novel recurrent translocation in 13 BCP-ALL patients. Fluorescence in situ hybridization and long-distance inverse polymerase chain reaction (PCR) identified ID4 as the partner gene. Breakpoints were scattered over a 19kb region centromeric of ID4. Quantitative real-time PCR showed up-regulation of ID4 mRNA. All patients had deletions of CDKN2A and PAX5 located on the short arm of chromosome 9, frequently as a result of an isochromosome, i(9)(q10) (9/13, 69%). This study defines a new subgroup of BCP-ALL characterized by ID4 over-expression and CDKN2A and PAX5 deletions. Preliminary survival data suggest that this subgroup may be associated with a good response to therapy. | lld:pubmed |
| pubmed-article:17940204 | pubmed:language | eng | lld:pubmed |
| pubmed-article:17940204 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17940204 | pubmed:citationSubset | AIM | lld:pubmed |
| pubmed-article:17940204 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17940204 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:17940204 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17940204 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17940204 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:17940204 | pubmed:month | Jan | lld:pubmed |
| pubmed-article:17940204 | pubmed:issn | 0006-4971 | lld:pubmed |
| pubmed-article:17940204 | pubmed:author | pubmed-author:AkasakaTakash... | lld:pubmed |
| pubmed-article:17940204 | pubmed:author | pubmed-author:ClaviezAlexan... | lld:pubmed |
| pubmed-article:17940204 | pubmed:author | pubmed-author:SiebertReiner... | lld:pubmed |
| pubmed-article:17940204 | pubmed:author | pubmed-author:GeskStefanS | lld:pubmed |
| pubmed-article:17940204 | pubmed:author | pubmed-author:HarderLanaL | lld:pubmed |
| pubmed-article:17940204 | pubmed:author | pubmed-author:DyerMartin... | lld:pubmed |
| pubmed-article:17940204 | pubmed:author | pubmed-author:MoormanAnthon... | lld:pubmed |
| pubmed-article:17940204 | pubmed:author | pubmed-author:HarrisonChris... | lld:pubmed |
| pubmed-article:17940204 | pubmed:author | pubmed-author:MazzulloHelen... | lld:pubmed |
| pubmed-article:17940204 | pubmed:author | pubmed-author:SugimotoKei-J... | lld:pubmed |
| pubmed-article:17940204 | pubmed:author | pubmed-author:RossFionaF | lld:pubmed |
| pubmed-article:17940204 | pubmed:author | pubmed-author:StreffordJona... | lld:pubmed |
| pubmed-article:17940204 | pubmed:author | pubmed-author:NagelIngaI | lld:pubmed |
| pubmed-article:17940204 | pubmed:author | pubmed-author:RussellLisa... | lld:pubmed |
| pubmed-article:17940204 | pubmed:author | pubmed-author:MajidAneelaA | lld:pubmed |
| pubmed-article:17940204 | pubmed:author | pubmed-author:Loraine... | lld:pubmed |
| pubmed-article:17940204 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:17940204 | pubmed:day | 1 | lld:pubmed |
| pubmed-article:17940204 | pubmed:volume | 111 | lld:pubmed |
| pubmed-article:17940204 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:17940204 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:17940204 | pubmed:pagination | 387-91 | lld:pubmed |
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| pubmed-article:17940204 | pubmed:year | 2008 | lld:pubmed |
| pubmed-article:17940204 | pubmed:articleTitle | t(6;14)(p22;q32): a new recurrent IGH@ translocation involving ID4 in B-cell precursor acute lymphoblastic leukemia (BCP-ALL). | lld:pubmed |
| pubmed-article:17940204 | pubmed:affiliation | Leukaemia Research Cytogenetics Group, Cancer Sciences Division, University of Southampton, Southampton General Hospital, Southampton, United Kingdom. | lld:pubmed |
| pubmed-article:17940204 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:17940204 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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