| pubmed-article:17935986 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:17935986 | lifeskim:mentions | umls-concept:C0033262 | lld:lifeskim |
| pubmed-article:17935986 | lifeskim:mentions | umls-concept:C0021467 | lld:lifeskim |
| pubmed-article:17935986 | lifeskim:mentions | umls-concept:C1418582 | lld:lifeskim |
| pubmed-article:17935986 | lifeskim:mentions | umls-concept:C0021469 | lld:lifeskim |
| pubmed-article:17935986 | pubmed:issue | 23 | lld:pubmed |
| pubmed-article:17935986 | pubmed:dateCreated | 2007-11-6 | lld:pubmed |
| pubmed-article:17935986 | pubmed:abstractText | Fmoc-pSer-Psi[(Z)CHC]-Pro-(2)-N-(3)-ethylaminoindole 1, showed moderate inhibition towards the mitotic regulator, Pin1 (IC(50)=28.3microM). To improve the cell permeability, the charged phosphate was masked as the bis-pivaloyloxymethyl (POM) phosphate in Fmoc-(bisPOM)-pSer-Psi[(Z)CHC]-Pro-(2)-N-(3)-ethylaminoindole 2. Antiproliferative activity towards A2780 ovarian cancer cells of 1 (IC(50)=46.2microM) was improved significantly in 2 (IC(50)=26.9microM), comparable to the IC(50) of 1 towards Pin1 enzymatic activity. | lld:pubmed |
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| pubmed-article:17935986 | pubmed:language | eng | lld:pubmed |
| pubmed-article:17935986 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17935986 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:17935986 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:17935986 | pubmed:month | Dec | lld:pubmed |
| pubmed-article:17935986 | pubmed:issn | 1464-3405 | lld:pubmed |
| pubmed-article:17935986 | pubmed:author | pubmed-author:ZhaoSongS | lld:pubmed |
| pubmed-article:17935986 | pubmed:author | pubmed-author:EtzkornFelici... | lld:pubmed |
| pubmed-article:17935986 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:17935986 | pubmed:day | 1 | lld:pubmed |
| pubmed-article:17935986 | pubmed:volume | 17 | lld:pubmed |
| pubmed-article:17935986 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:17935986 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:17935986 | pubmed:pagination | 6615-8 | lld:pubmed |
| pubmed-article:17935986 | pubmed:dateRevised | 2010-9-16 | lld:pubmed |
| pubmed-article:17935986 | pubmed:meshHeading | pubmed-meshheading:17935986... | lld:pubmed |
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| pubmed-article:17935986 | pubmed:meshHeading | pubmed-meshheading:17935986... | lld:pubmed |
| pubmed-article:17935986 | pubmed:year | 2007 | lld:pubmed |
| pubmed-article:17935986 | pubmed:articleTitle | A phosphorylated prodrug for the inhibition of Pin1. | lld:pubmed |
| pubmed-article:17935986 | pubmed:affiliation | Department of Chemistry, Virginia Tech, Blacksburg, VA 24061-0212, USA. | lld:pubmed |
| pubmed-article:17935986 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:17935986 | pubmed:publicationType | Comparative Study | lld:pubmed |
| pubmed-article:17935986 | pubmed:publicationType | Research Support, N.I.H., Extramural | lld:pubmed |
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