| pubmed-article:17933794 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:17933794 | lifeskim:mentions | umls-concept:C0033414 | lld:lifeskim |
| pubmed-article:17933794 | lifeskim:mentions | umls-concept:C1521761 | lld:lifeskim |
| pubmed-article:17933794 | lifeskim:mentions | umls-concept:C2755105 | lld:lifeskim |
| pubmed-article:17933794 | lifeskim:mentions | umls-concept:C0162610 | lld:lifeskim |
| pubmed-article:17933794 | lifeskim:mentions | umls-concept:C1334043 | lld:lifeskim |
| pubmed-article:17933794 | pubmed:issue | 21 | lld:pubmed |
| pubmed-article:17933794 | pubmed:dateCreated | 2007-10-15 | lld:pubmed |
| pubmed-article:17933794 | pubmed:abstractText | In this report, we investigate the C. elegans CBFbeta homologue, BRO-1. bro-1 mutants have a similar male-specific sensory ray loss phenotype to rnt-1 (the C. elegans homologue of the mammalian CBFbeta-interacting Runx factors), caused by failed cell divisions in the seam lineages. Our studies indicate that BRO-1 and RNT-1 form a cell proliferation-promoting complex, and that BRO-1 increases both the affinity and specificity of RNT-1-DNA interactions. Overexpression of bro-1, like rnt-1, leads to an expansion of seam cell number and co-overexpression of bro-1 and rnt-1 results in massive seam cell hyperplasia. Finally, we find that BRO-1 appears to act independently of RNT-1 in certain situations. These studies provide new insights into the function and regulation of this important cancer-associated DNA-binding complex in stem cells and support the view that Runx/CBFbeta factors have oncogenic potential. | lld:pubmed |
| pubmed-article:17933794 | pubmed:language | eng | lld:pubmed |
| pubmed-article:17933794 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17933794 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:17933794 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17933794 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17933794 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:17933794 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17933794 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:17933794 | pubmed:month | Nov | lld:pubmed |
| pubmed-article:17933794 | pubmed:issn | 0950-1991 | lld:pubmed |
| pubmed-article:17933794 | pubmed:author | pubmed-author:KoharaYujiY | lld:pubmed |
| pubmed-article:17933794 | pubmed:author | pubmed-author:TanakaJunkoJ | lld:pubmed |
| pubmed-article:17933794 | pubmed:author | pubmed-author:MiwaYoshihiro... | lld:pubmed |
| pubmed-article:17933794 | pubmed:author | pubmed-author:MitaniShoheiS | lld:pubmed |
| pubmed-article:17933794 | pubmed:author | pubmed-author:NimmoRachaelR | lld:pubmed |
| pubmed-article:17933794 | pubmed:author | pubmed-author:WoollardAliso... | lld:pubmed |
| pubmed-article:17933794 | pubmed:author | pubmed-author:KagoshimaHiro... | lld:pubmed |
| pubmed-article:17933794 | pubmed:author | pubmed-author:SaadNicoleN | lld:pubmed |
| pubmed-article:17933794 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:17933794 | pubmed:volume | 134 | lld:pubmed |
| pubmed-article:17933794 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:17933794 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:17933794 | pubmed:pagination | 3905-15 | lld:pubmed |
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| pubmed-article:17933794 | pubmed:meshHeading | pubmed-meshheading:17933794... | lld:pubmed |
| pubmed-article:17933794 | pubmed:year | 2007 | lld:pubmed |
| pubmed-article:17933794 | pubmed:articleTitle | The C. elegans CBFbeta homologue BRO-1 interacts with the Runx factor, RNT-1, to promote stem cell proliferation and self-renewal. | lld:pubmed |
| pubmed-article:17933794 | pubmed:affiliation | Genome Biology Laboratory, National Institute of Genetics, Mishima 411-8560, Japan. hkagoshi@lab.nig.ac.jp | lld:pubmed |
| pubmed-article:17933794 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:17933794 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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