| pubmed-article:17875704 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:17875704 | lifeskim:mentions | umls-concept:C0006142 | lld:lifeskim |
| pubmed-article:17875704 | lifeskim:mentions | umls-concept:C0680063 | lld:lifeskim |
| pubmed-article:17875704 | lifeskim:mentions | umls-concept:C0242767 | lld:lifeskim |
| pubmed-article:17875704 | lifeskim:mentions | umls-concept:C0006826 | lld:lifeskim |
| pubmed-article:17875704 | lifeskim:mentions | umls-concept:C0038250 | lld:lifeskim |
| pubmed-article:17875704 | lifeskim:mentions | umls-concept:C1186763 | lld:lifeskim |
| pubmed-article:17875704 | lifeskim:mentions | umls-concept:C1326912 | lld:lifeskim |
| pubmed-article:17875704 | lifeskim:mentions | umls-concept:C0040690 | lld:lifeskim |
| pubmed-article:17875704 | lifeskim:mentions | umls-concept:C1280500 | lld:lifeskim |
| pubmed-article:17875704 | lifeskim:mentions | umls-concept:C1520166 | lld:lifeskim |
| pubmed-article:17875704 | lifeskim:mentions | umls-concept:C1171947 | lld:lifeskim |
| pubmed-article:17875704 | pubmed:issue | 18 | lld:pubmed |
| pubmed-article:17875704 | pubmed:dateCreated | 2007-9-18 | lld:pubmed |
| pubmed-article:17875704 | pubmed:abstractText | The transforming growth factor-beta (TGF-beta) pathway has tumor-suppressor activity in many epithelial tissues. Because TGF-beta is a potent inhibitor of epithelial cell proliferation, it has been widely assumed that this property underlies the tumor-suppressor effect. Here, we have used a xenograft model of breast cancer to show that endogenous TGF-beta has the potential to suppress tumorigenesis through a novel mechanism, involving effects at two distinct levels in the hierarchy of cellular progeny that make up the epithelial component of the tumor. First, TGF-beta reduces the size of the putative cancer stem or early progenitor cell population, and second it promotes differentiation of a more committed, but highly proliferative, progenitor cell population to an intrinsically less proliferative state. We further show that reduced expression of the type II TGF-beta receptor correlates with loss of luminal differentiation in a clinical breast cancer cohort, suggesting that this mechanism may be clinically relevant. At a molecular level, the induction of differentiation by TGF-beta involves down-regulation of Id1, and forced overexpression of Id1 can promote tumorigenesis despite persistence of the antiproliferative effect of TGF-beta. These data suggest new roles for the TGF-beta pathway in regulating tumor cell dynamics that are independent of direct effects on proliferation. | lld:pubmed |
| pubmed-article:17875704 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17875704 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17875704 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17875704 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17875704 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17875704 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17875704 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17875704 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17875704 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17875704 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17875704 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17875704 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17875704 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17875704 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17875704 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17875704 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17875704 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17875704 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17875704 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17875704 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17875704 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17875704 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17875704 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17875704 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17875704 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17875704 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17875704 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17875704 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17875704 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17875704 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17875704 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17875704 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17875704 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17875704 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17875704 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17875704 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17875704 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17875704 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17875704 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17875704 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17875704 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17875704 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17875704 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17875704 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17875704 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17875704 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17875704 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17875704 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17875704 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17875704 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17875704 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17875704 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17875704 | pubmed:language | eng | lld:pubmed |
| pubmed-article:17875704 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17875704 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:17875704 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17875704 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17875704 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17875704 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17875704 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17875704 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17875704 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:17875704 | pubmed:month | Sep | lld:pubmed |
| pubmed-article:17875704 | pubmed:issn | 0008-5472 | lld:pubmed |
| pubmed-article:17875704 | pubmed:author | pubmed-author:ParksW TonyWT | lld:pubmed |
| pubmed-article:17875704 | pubmed:author | pubmed-author:WakefieldLala... | lld:pubmed |
| pubmed-article:17875704 | pubmed:author | pubmed-author:OoshimaAkiraA | lld:pubmed |
| pubmed-article:17875704 | pubmed:author | pubmed-author:MamuraMizukoM | lld:pubmed |
| pubmed-article:17875704 | pubmed:author | pubmed-author:TangBinwuB | lld:pubmed |
| pubmed-article:17875704 | pubmed:author | pubmed-author:DesprezPierre... | lld:pubmed |
| pubmed-article:17875704 | pubmed:author | pubmed-author:AnverMiriam... | lld:pubmed |
| pubmed-article:17875704 | pubmed:author | pubmed-author:NamJeong-Seok... | lld:pubmed |
| pubmed-article:17875704 | pubmed:author | pubmed-author:DuZhijunZ | lld:pubmed |
| pubmed-article:17875704 | pubmed:author | pubmed-author:ShihJoannaJ | lld:pubmed |
| pubmed-article:17875704 | pubmed:author | pubmed-author:VuMaryM | lld:pubmed |
| pubmed-article:17875704 | pubmed:author | pubmed-author:MichalowskaAl... | lld:pubmed |
| pubmed-article:17875704 | pubmed:author | pubmed-author:YooNaomiN | lld:pubmed |
| pubmed-article:17875704 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:17875704 | pubmed:day | 15 | lld:pubmed |
| pubmed-article:17875704 | pubmed:volume | 67 | lld:pubmed |
| pubmed-article:17875704 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:17875704 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:17875704 | pubmed:pagination | 8643-52 | lld:pubmed |
| pubmed-article:17875704 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
| pubmed-article:17875704 | pubmed:meshHeading | pubmed-meshheading:17875704... | lld:pubmed |
