| pubmed-article:17868958 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:17868958 | lifeskim:mentions | umls-concept:C0001483 | lld:lifeskim |
| pubmed-article:17868958 | lifeskim:mentions | umls-concept:C0206679 | lld:lifeskim |
| pubmed-article:17868958 | lifeskim:mentions | umls-concept:C0019704 | lld:lifeskim |
| pubmed-article:17868958 | lifeskim:mentions | umls-concept:C0039194 | lld:lifeskim |
| pubmed-article:17868958 | lifeskim:mentions | umls-concept:C1704632 | lld:lifeskim |
| pubmed-article:17868958 | lifeskim:mentions | umls-concept:C0871261 | lld:lifeskim |
| pubmed-article:17868958 | lifeskim:mentions | umls-concept:C2911692 | lld:lifeskim |
| pubmed-article:17868958 | lifeskim:mentions | umls-concept:C1706817 | lld:lifeskim |
| pubmed-article:17868958 | lifeskim:mentions | umls-concept:C0442335 | lld:lifeskim |
| pubmed-article:17868958 | lifeskim:mentions | umls-concept:C1511253 | lld:lifeskim |
| pubmed-article:17868958 | pubmed:issue | 42 | lld:pubmed |
| pubmed-article:17868958 | pubmed:dateCreated | 2007-10-2 | lld:pubmed |
| pubmed-article:17868958 | pubmed:abstractText | HSV-1 amplicon vectors elicit strong T-cell responses to encoded antigens but the qualitative nature of these responses is poorly understood. Antigen-specific CD4(+) and CD8(+) T-cell responses to amplicon and adenovirus (rAd5) vectors encoding HIV-1 gp120 were assessed following immunization of mice, by performing intracellular cytokine staining for IFNgamma, IL2 and TNFalpha, following stimulation of splenocytes with a HIV-1 Env peptide pool. The quality of the primary T-cell response to amplicon and rAd5 vectors was strikingly similar, but there were qualitative differences in responses to amplicon vectors that incorporated different promoters upstream of gp120 - suggesting that promoters can significantly influence immune response quality. When prime-boost combinations were studied, a rAd5 prime and amplicon boost elicited the highest T-cell response. Furthermore, protocols that incorporated a rAd5 prime consistently elicited a greater proportion of polyfunctional CD4(+) T-cells-regardless of boost. This suggests that initial priming can shape immune response quality after a boost. Overall, these findings provide insight into effective vector combinations for HIV-1 vaccine development. | lld:pubmed |
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| pubmed-article:17868958 | pubmed:language | eng | lld:pubmed |
| pubmed-article:17868958 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17868958 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:17868958 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:17868958 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:17868958 | pubmed:month | Oct | lld:pubmed |
| pubmed-article:17868958 | pubmed:issn | 0264-410X | lld:pubmed |
| pubmed-article:17868958 | pubmed:author | pubmed-author:BowersWilliam... | lld:pubmed |
| pubmed-article:17868958 | pubmed:author | pubmed-author:FederoffHowar... | lld:pubmed |
| pubmed-article:17868958 | pubmed:author | pubmed-author:KeeferMichael... | lld:pubmed |
| pubmed-article:17868958 | pubmed:author | pubmed-author:DewhurstSteph... | lld:pubmed |
| pubmed-article:17868958 | pubmed:author | pubmed-author:MaguireCasey... | lld:pubmed |
| pubmed-article:17868958 | pubmed:author | pubmed-author:DukeCindy M... | lld:pubmed |
| pubmed-article:17868958 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:17868958 | pubmed:day | 16 | lld:pubmed |
