| pubmed-article:17804806 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:17804806 | lifeskim:mentions | umls-concept:C0026809 | lld:lifeskim |
| pubmed-article:17804806 | lifeskim:mentions | umls-concept:C0250501 | lld:lifeskim |
| pubmed-article:17804806 | lifeskim:mentions | umls-concept:C0018951 | lld:lifeskim |
| pubmed-article:17804806 | lifeskim:mentions | umls-concept:C0205307 | lld:lifeskim |
| pubmed-article:17804806 | lifeskim:mentions | umls-concept:C1332817 | lld:lifeskim |
| pubmed-article:17804806 | lifeskim:mentions | umls-concept:C0011155 | lld:lifeskim |
| pubmed-article:17804806 | lifeskim:mentions | umls-concept:C1835886 | lld:lifeskim |
| pubmed-article:17804806 | lifeskim:mentions | umls-concept:C2263229 | lld:lifeskim |
| pubmed-article:17804806 | pubmed:issue | 37 | lld:pubmed |
| pubmed-article:17804806 | pubmed:dateCreated | 2007-9-12 | lld:pubmed |
| pubmed-article:17804806 | pubmed:databankReference | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17804806 | pubmed:abstractText | Chemotactic cytokines (chemokines) attract immune cells, although their original evolutionary role may relate more closely with embryonic development. We noted differential expression of the chemokine receptor CXCR7 (RDC-1) on marginal zone B cells, a cell type associated with autoimmune diseases. We generated Cxcr7(-/-) mice but found that CXCR7 deficiency had little effect on B cell composition. However, most Cxcr7(-/-) mice died at birth with ventricular septal defects and semilunar heart valve malformation. Conditional deletion of Cxcr7 in endothelium, using Tie2-Cre transgenic mice, recapitulated this phenotype. Gene profiling of Cxcr7(-/-) heart valve leaflets revealed a defect in the expression of factors essential for valve formation, vessel protection, or endothelial cell growth and survival. We confirmed that the principal chemokine ligand for CXCR7 was CXCL12/SDF-1, which also binds CXCR4. CXCL12 did not induce signaling through CXCR7; however, CXCR7 formed functional heterodimers with CXCR4 and enhanced CXCL12-induced signaling. Our results reveal a specialized role for CXCR7 in endothelial biology and valve development and highlight the distinct developmental role of evolutionary conserved chemokine receptors such as CXCR7 and CXCR4. | lld:pubmed |
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| pubmed-article:17804806 | pubmed:language | eng | lld:pubmed |
| pubmed-article:17804806 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17804806 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:17804806 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:17804806 | pubmed:month | Sep | lld:pubmed |
| pubmed-article:17804806 | pubmed:issn | 0027-8424 | lld:pubmed |
| pubmed-article:17804806 | pubmed:author | pubmed-author:MackayCharles... | lld:pubmed |
| pubmed-article:17804806 | pubmed:author | pubmed-author:RansohoffRich... | lld:pubmed |
| pubmed-article:17804806 | pubmed:author | pubmed-author:GroomJoannaJ | lld:pubmed |
| pubmed-article:17804806 | pubmed:author | pubmed-author:BattenMarcelM | lld:pubmed |
| pubmed-article:17804806 | pubmed:author | pubmed-author:MackayFabienn... | lld:pubmed |
| pubmed-article:17804806 | pubmed:author | pubmed-author:HarveyRichard... | lld:pubmed |
| pubmed-article:17804806 | pubmed:author | pubmed-author:Martínez-ACar... | lld:pubmed |
| pubmed-article:17804806 | pubmed:author | pubmed-author:MelladoMarioM | lld:pubmed |
| pubmed-article:17804806 | pubmed:author | pubmed-author:BibenChristin... | lld:pubmed |
| pubmed-article:17804806 | pubmed:author | pubmed-author:LiMeizhangM | lld:pubmed |
| pubmed-article:17804806 | pubmed:author | pubmed-author:Martínez-Muño... | lld:pubmed |
| pubmed-article:17804806 | pubmed:author | pubmed-author:WoehlBlancheB | lld:pubmed |
| pubmed-article:17804806 | pubmed:author | pubmed-author:SierroFrederi... | lld:pubmed |
| pubmed-article:17804806 | pubmed:author | pubmed-author:LeungHelenH | lld:pubmed |
| pubmed-article:17804806 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:17804806 | pubmed:day | 11 | lld:pubmed |
| pubmed-article:17804806 | pubmed:volume | 104 | lld:pubmed |
| pubmed-article:17804806 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:17804806 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:17804806 | pubmed:pagination | 14759-64 | lld:pubmed |
| pubmed-article:17804806 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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