| pubmed-article:17804792 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:17804792 | lifeskim:mentions | umls-concept:C0026609 | lld:lifeskim |
| pubmed-article:17804792 | lifeskim:mentions | umls-concept:C0004112 | lld:lifeskim |
| pubmed-article:17804792 | lifeskim:mentions | umls-concept:C0679109 | lld:lifeskim |
| pubmed-article:17804792 | lifeskim:mentions | umls-concept:C0017262 | lld:lifeskim |
| pubmed-article:17804792 | lifeskim:mentions | umls-concept:C1415288 | lld:lifeskim |
| pubmed-article:17804792 | lifeskim:mentions | umls-concept:C0851285 | lld:lifeskim |
| pubmed-article:17804792 | lifeskim:mentions | umls-concept:C2911684 | lld:lifeskim |
| pubmed-article:17804792 | lifeskim:mentions | umls-concept:C0185117 | lld:lifeskim |
| pubmed-article:17804792 | pubmed:issue | 37 | lld:pubmed |
| pubmed-article:17804792 | pubmed:dateCreated | 2007-9-12 | lld:pubmed |
| pubmed-article:17804792 | pubmed:abstractText | Influx of Ca(2+) ions through alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid (AMPA) receptors contributes to neuronal damage in stroke, epilepsy, and neurodegenerative disorders such as ALS. The Ca(2+) permeability of AMPA receptors is largely determined by the glutamate receptor 2 (GluR2) subunit, receptors lacking GluR2 being permeable to Ca(2+) ions. We identified a difference in GluR2 expression in motor neurons from two rat strains, resulting in a difference in vulnerability to AMPA receptor-mediated excitotoxicity both in vitro and in vivo. Astrocytes from the ventral spinal cord were found to mediate this difference in GluR2 expression in motor neurons. The presence of ALS-causing mutant superoxide dismutase 1 in astrocytes abolished their GluR2-regulating capacity and thus affected motor neuron vulnerability to AMPA receptor-mediated excitotoxicity. These results reveal a mechanism through which astrocytes influence neuronal functioning in health and disease. | lld:pubmed |
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| pubmed-article:17804792 | pubmed:language | eng | lld:pubmed |
| pubmed-article:17804792 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17804792 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:17804792 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:17804792 | pubmed:month | Sep | lld:pubmed |
| pubmed-article:17804792 | pubmed:issn | 0027-8424 | lld:pubmed |
| pubmed-article:17804792 | pubmed:author | pubmed-author:CarmelietPete... | lld:pubmed |
| pubmed-article:17804792 | pubmed:author | pubmed-author:HerijgersPaul... | lld:pubmed |
| pubmed-article:17804792 | pubmed:author | pubmed-author:CallewaertGee... | lld:pubmed |
| pubmed-article:17804792 | pubmed:author | pubmed-author:TimmermanVinc... | lld:pubmed |
| pubmed-article:17804792 | pubmed:author | pubmed-author:Van Den... | lld:pubmed |
| pubmed-article:17804792 | pubmed:author | pubmed-author:RobberechtWim... | lld:pubmed |
| pubmed-article:17804792 | pubmed:author | pubmed-author:VerhoevenKris... | lld:pubmed |
| pubmed-article:17804792 | pubmed:author | pubmed-author:Van... | lld:pubmed |
| pubmed-article:17804792 | pubmed:author | pubmed-author:VerpoortenNat... | lld:pubmed |
| pubmed-article:17804792 | pubmed:author | pubmed-author:DewilMaartenM | lld:pubmed |
| pubmed-article:17804792 | pubmed:author | pubmed-author:ScheveneelsWe... | lld:pubmed |
| pubmed-article:17804792 | pubmed:author | pubmed-author:HersmusNicole... | lld:pubmed |
| pubmed-article:17804792 | pubmed:author | pubmed-author:BraekenDriesD | lld:pubmed |
| pubmed-article:17804792 | pubmed:author | pubmed-author:BogaertElkeE | lld:pubmed |
| pubmed-article:17804792 | pubmed:author | pubmed-author:BockxIlseI | lld:pubmed |
| pubmed-article:17804792 | pubmed:author | pubmed-author:KiralyDoraD | lld:pubmed |
| pubmed-article:17804792 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:17804792 | pubmed:day | 11 | lld:pubmed |
| pubmed-article:17804792 | pubmed:volume | 104 | lld:pubmed |
| pubmed-article:17804792 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:17804792 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:17804792 | pubmed:pagination | 14825-30 | lld:pubmed |
| pubmed-article:17804792 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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