| pubmed-article:1775198 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:1775198 | lifeskim:mentions | umls-concept:C0036945 | lld:lifeskim |
| pubmed-article:1775198 | lifeskim:mentions | umls-concept:C0018787 | lld:lifeskim |
| pubmed-article:1775198 | lifeskim:mentions | umls-concept:C0034144 | lld:lifeskim |
| pubmed-article:1775198 | lifeskim:mentions | umls-concept:C0032821 | lld:lifeskim |
| pubmed-article:1775198 | lifeskim:mentions | umls-concept:C0042523 | lld:lifeskim |
| pubmed-article:1775198 | lifeskim:mentions | umls-concept:C0021467 | lld:lifeskim |
| pubmed-article:1775198 | lifeskim:mentions | umls-concept:C0030163 | lld:lifeskim |
| pubmed-article:1775198 | lifeskim:mentions | umls-concept:C0021469 | lld:lifeskim |
| pubmed-article:1775198 | lifeskim:mentions | umls-concept:C0521116 | lld:lifeskim |
| pubmed-article:1775198 | lifeskim:mentions | umls-concept:C1527240 | lld:lifeskim |
| pubmed-article:1775198 | lifeskim:mentions | umls-concept:C0078728 | lld:lifeskim |
| pubmed-article:1775198 | pubmed:issue | 6 | lld:pubmed |
| pubmed-article:1775198 | pubmed:dateCreated | 1992-3-5 | lld:pubmed |
| pubmed-article:1775198 | pubmed:abstractText | The electrophysiologic mode of action and potency of the verapamil derivative YS 035 (N,N-bis-(3,4-dimethoxyphenethyl)-N-methyl amine) were investigated in sheep cardiac Purkinje fibres. Action potential duration measured at a repolarization level of -60 mV (APD-60) and membrane currents recorded with the two-microelectrode voltage-clamp technique were evaluated. At 10 mumols/l YS 035 APD-60 was increased to about 115% of reference. Prolongation measured as percentage of the respective control exhibited on the average no dependence on stimulation frequency (0.17-2 Hz). At 100 mumols/l membrane became depolarized to about -50 mV and action potentials could no longer be elicited. Further study was focussed on effects on outward currents, mostly activated at a frequency of 0.05 Hz. Transient outward current (ito) was completely blocked at 100 mumols/l and half-maximal inhibition occurred at about 14 mumols/l. Inwardly rectifying potassium current (ik1) was reduced to 47% of reference at 100 mumols/l. An initially activating outward current at positive membrane potentials (iinst) was reduced to 73% at 100 mumols/l. Time-dependent (delayed) outward current (iK) was on the average not affected up to 100 mumols/l. Besides inhibition of repolarizing outward currents YS 035 completely blocked pacemaker current (if) at 100 mumols/l and half-maximal reduction was achieved at 5 mumols/l. YS 035 (1-100 mumols/l) did not clearly affect time constants of activation at selected test potentials (IK: +35 mV; if: -90 mV) or inactivation (ito: 0 mV). Voltage-dependent control mechanisms of currents (ito, if) were not influenced by YS 035 but the amount of available current was reduced.(ABSTRACT TRUNCATED AT 250 WORDS) | lld:pubmed |
| pubmed-article:1775198 | pubmed:language | eng | lld:pubmed |
| pubmed-article:1775198 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1775198 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:1775198 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1775198 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1775198 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1775198 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:1775198 | pubmed:month | Dec | lld:pubmed |
| pubmed-article:1775198 | pubmed:issn | 0028-1298 | lld:pubmed |
| pubmed-article:1775198 | pubmed:author | pubmed-author:BergerFF | lld:pubmed |
| pubmed-article:1775198 | pubmed:author | pubmed-author:BorchardUU | lld:pubmed |
| pubmed-article:1775198 | pubmed:author | pubmed-author:WeisTT | lld:pubmed |
| pubmed-article:1775198 | pubmed:author | pubmed-author:HafnerDD | lld:pubmed |
| pubmed-article:1775198 | pubmed:author | pubmed-author:KammerTT | lld:pubmed |
| pubmed-article:1775198 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:1775198 | pubmed:volume | 344 | lld:pubmed |
| pubmed-article:1775198 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:1775198 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:1775198 | pubmed:pagination | 653-61 | lld:pubmed |
| pubmed-article:1775198 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
| pubmed-article:1775198 | pubmed:meshHeading | pubmed-meshheading:1775198-... | lld:pubmed |
| pubmed-article:1775198 | pubmed:meshHeading | pubmed-meshheading:1775198-... | lld:pubmed |
| pubmed-article:1775198 | pubmed:meshHeading | pubmed-meshheading:1775198-... | lld:pubmed |
| pubmed-article:1775198 | pubmed:meshHeading | pubmed-meshheading:1775198-... | lld:pubmed |
| pubmed-article:1775198 | pubmed:meshHeading | pubmed-meshheading:1775198-... | lld:pubmed |
| pubmed-article:1775198 | pubmed:meshHeading | pubmed-meshheading:1775198-... | lld:pubmed |
| pubmed-article:1775198 | pubmed:meshHeading | pubmed-meshheading:1775198-... | lld:pubmed |
| pubmed-article:1775198 | pubmed:meshHeading | pubmed-meshheading:1775198-... | lld:pubmed |
| pubmed-article:1775198 | pubmed:meshHeading | pubmed-meshheading:1775198-... | lld:pubmed |
| pubmed-article:1775198 | pubmed:year | 1991 | lld:pubmed |
| pubmed-article:1775198 | pubmed:articleTitle | Inhibition of potassium outward currents and pacemaker current in sheep cardiac Purkinje fibres by the verapamil derivative YS 035. | lld:pubmed |
| pubmed-article:1775198 | pubmed:affiliation | Institut für Pharmakologie, Universität Düsseldorf, Federal Republic of Germany. | lld:pubmed |
| pubmed-article:1775198 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:1775198 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
