| pubmed-article:17713715 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:17713715 | lifeskim:mentions | umls-concept:C0003864 | lld:lifeskim |
| pubmed-article:17713715 | lifeskim:mentions | umls-concept:C0024141 | lld:lifeskim |
| pubmed-article:17713715 | lifeskim:mentions | umls-concept:C0021745 | lld:lifeskim |
| pubmed-article:17713715 | lifeskim:mentions | umls-concept:C0004083 | lld:lifeskim |
| pubmed-article:17713715 | lifeskim:mentions | umls-concept:C0678951 | lld:lifeskim |
| pubmed-article:17713715 | pubmed:issue | 11 | lld:pubmed |
| pubmed-article:17713715 | pubmed:dateCreated | 2007-10-1 | lld:pubmed |
| pubmed-article:17713715 | pubmed:abstractText | Systemic lupus erythematosus (SLE) is a complex autoimmune disease in which genetic factors strongly influence susceptibility. Cytokines such as the interferon-gamma (IFNG) gene play a key role in controlling the immunity and inflammation, and therefore their polymorphisms may affect these genes' expression levels among individuals. We investigated the frequency of IFNG gene intron (+874) polymorphism, previously reported to be associated with IFNG production, in SLE patients compared to a control group. This population-based case-control study includes 154 SLE patients and 154 healthy control subjects with similar ethnic backgrounds. The genotyping was determined by polymerase chain reaction sequence-specific primer method and using the Chi-squared test for analyzing the association between this single-nucleotide polymorphism and SLE. The allele frequencies of the IFNG (+874) gene polymorphism were not significantly different between SLE patients and control subjects (72.7 vs 77%). However, there was a significant association between A dominance model of inheritance with arthritis (odds ratio = 7.64, 95% confidence interval = 1.56-41.64, P = 0.006, P(c) = 0.03). The result suggested that the +874 intron polymorphism of IFNG can be used as the marker for SLE susceptibility with arthritis in the Thai population. | lld:pubmed |
| pubmed-article:17713715 | pubmed:language | eng | lld:pubmed |
| pubmed-article:17713715 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17713715 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:17713715 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17713715 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:17713715 | pubmed:month | Nov | lld:pubmed |
| pubmed-article:17713715 | pubmed:issn | 0770-3198 | lld:pubmed |
| pubmed-article:17713715 | pubmed:author | pubmed-author:AvihingsanonY... | lld:pubmed |
| pubmed-article:17713715 | pubmed:author | pubmed-author:WongchinsriJe... | lld:pubmed |
| pubmed-article:17713715 | pubmed:author | pubmed-author:Wongpiyabovor... | lld:pubmed |
| pubmed-article:17713715 | pubmed:author | pubmed-author:Tangwattanach... | lld:pubmed |
| pubmed-article:17713715 | pubmed:author | pubmed-author:HirankarnNatt... | lld:pubmed |
| pubmed-article:17713715 | pubmed:author | pubmed-author:SodsaiPimpaya... | lld:pubmed |
| pubmed-article:17713715 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:17713715 | pubmed:volume | 26 | lld:pubmed |
| pubmed-article:17713715 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:17713715 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:17713715 | pubmed:pagination | 1921-4 | lld:pubmed |
| pubmed-article:17713715 | pubmed:dateRevised | 2008-11-21 | lld:pubmed |
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| pubmed-article:17713715 | pubmed:meshHeading | pubmed-meshheading:17713715... | lld:pubmed |
| pubmed-article:17713715 | pubmed:meshHeading | pubmed-meshheading:17713715... | lld:pubmed |
| pubmed-article:17713715 | pubmed:meshHeading | pubmed-meshheading:17713715... | lld:pubmed |
| pubmed-article:17713715 | pubmed:meshHeading | pubmed-meshheading:17713715... | lld:pubmed |
| pubmed-article:17713715 | pubmed:meshHeading | pubmed-meshheading:17713715... | lld:pubmed |
| pubmed-article:17713715 | pubmed:meshHeading | pubmed-meshheading:17713715... | lld:pubmed |
| pubmed-article:17713715 | pubmed:meshHeading | pubmed-meshheading:17713715... | lld:pubmed |
| pubmed-article:17713715 | pubmed:meshHeading | pubmed-meshheading:17713715... | lld:pubmed |
| pubmed-article:17713715 | pubmed:meshHeading | pubmed-meshheading:17713715... | lld:pubmed |
| pubmed-article:17713715 | pubmed:year | 2007 | lld:pubmed |
| pubmed-article:17713715 | pubmed:articleTitle | Association of interferon-gamma gene polymorphism (+874A) with arthritis manifestation in SLE. | lld:pubmed |
| pubmed-article:17713715 | pubmed:affiliation | Lupus Research Unit, Department of Microbiology, Faculty of Medicine, Chulalongkorn University, Rama 4 road, Bangkok, 10330, Thailand. | lld:pubmed |
| pubmed-article:17713715 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:17713715 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| entrez-gene:3458 | entrezgene:pubmed | pubmed-article:17713715 | lld:entrezgene |
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| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:17713715 | lld:pubmed |
