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pubmed-article:17705579pubmed:abstractTextSirolimus is an agent with lymphocyte-specific features similar to those of calcineurin inhibitors but with a different mechanism of action and safety profile. To optimize the use of sirolimus-based immunosuppression, further investigation of appropriate pharmacokinetic (sirolimus exposure) and pharmacodynamic (sirolimus T-cell immunomodulator effect) monitoring is required to determine personalized target concentrations.lld:pubmed
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pubmed-article:17705579pubmed:articleTitleT-cell function monitoring in stable renal transplant patients treated with sirolimus monotherapy.lld:pubmed
pubmed-article:17705579pubmed:affiliationLaboratorio de Farmacología, Centre de Diagnòstic Biomèdic, IDIBAPS, Hospital Clínic, Barcelona University, Barcelona, Spain. mbrunet@clinic.ub.eslld:pubmed
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