| pubmed-article:17703434 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:17703434 | lifeskim:mentions | umls-concept:C0086418 | lld:lifeskim |
| pubmed-article:17703434 | lifeskim:mentions | umls-concept:C0087111 | lld:lifeskim |
| pubmed-article:17703434 | lifeskim:mentions | umls-concept:C0034693 | lld:lifeskim |
| pubmed-article:17703434 | lifeskim:mentions | umls-concept:C0035094 | lld:lifeskim |
| pubmed-article:17703434 | lifeskim:mentions | umls-concept:C0597357 | lld:lifeskim |
| pubmed-article:17703434 | lifeskim:mentions | umls-concept:C0017337 | lld:lifeskim |
| pubmed-article:17703434 | lifeskim:mentions | umls-concept:C0003017 | lld:lifeskim |
| pubmed-article:17703434 | lifeskim:mentions | umls-concept:C1960108 | lld:lifeskim |
| pubmed-article:17703434 | lifeskim:mentions | umls-concept:C1883709 | lld:lifeskim |
| pubmed-article:17703434 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:17703434 | pubmed:dateCreated | 2007-8-17 | lld:pubmed |
| pubmed-article:17703434 | pubmed:abstractText | We studied the effects of extremely low-dose human renin inhibition (aliskiren) with low angiotensin II receptor blockade (losartan) in a novel double-transgenic rat model harbouring both human renin and angiotensinogen genes. We found that low-dose aliskiren and low-dose losartan effectively reduced mortality and target-organ damage with minimal, non-significant, effects on blood pressure (BP). Our data suggest that renin-angiotensin system (RAS) inhibition ameliorates target-organ damage in an Ang II-driven model of hypertension. Direct renin inhibition is equally efficacious in this regard. Our study does not fully answer the question of BP-lowering versus RAS inhibition. This question is important and was at least partially addressed with our low-dose model. | lld:pubmed |
| pubmed-article:17703434 | pubmed:language | eng | lld:pubmed |
| pubmed-article:17703434 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17703434 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:17703434 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:17703434 | pubmed:month | Jun | lld:pubmed |
| pubmed-article:17703434 | pubmed:issn | 1470-3203 | lld:pubmed |
| pubmed-article:17703434 | pubmed:author | pubmed-author:MeinersSilkeS | lld:pubmed |
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| pubmed-article:17703434 | pubmed:author | pubmed-author:MullerDominik... | lld:pubmed |
| pubmed-article:17703434 | pubmed:author | pubmed-author:PilzBernhardB | lld:pubmed |
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| pubmed-article:17703434 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:17703434 | pubmed:volume | 8 | lld:pubmed |
| pubmed-article:17703434 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:17703434 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:17703434 | pubmed:pagination | 81-4 | lld:pubmed |
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| pubmed-article:17703434 | pubmed:year | 2007 | lld:pubmed |
| pubmed-article:17703434 | pubmed:articleTitle | Low-dose renin inhibitor and low-dose AT(1)-receptor blocker therapy ameliorate target-organ damage in rats harbouring human renin and angiotensinogen genes. | lld:pubmed |
| pubmed-article:17703434 | pubmed:affiliation | Universitary Medicine Berlin, Charite Campus Buch, Franz Volhard Clinic, HELIOS Klinikum-Berlin, Germany. | lld:pubmed |
| pubmed-article:17703434 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:17703434 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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