| pubmed-article:17696955 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:17696955 | lifeskim:mentions | umls-concept:C0699791 | lld:lifeskim |
| pubmed-article:17696955 | lifeskim:mentions | umls-concept:C0033684 | lld:lifeskim |
| pubmed-article:17696955 | lifeskim:mentions | umls-concept:C1366450 | lld:lifeskim |
| pubmed-article:17696955 | lifeskim:mentions | umls-concept:C1441616 | lld:lifeskim |
| pubmed-article:17696955 | lifeskim:mentions | umls-concept:C0936012 | lld:lifeskim |
| pubmed-article:17696955 | pubmed:issue | 8 | lld:pubmed |
| pubmed-article:17696955 | pubmed:dateCreated | 2007-8-16 | lld:pubmed |
| pubmed-article:17696955 | pubmed:abstractText | Mounting evidence indicates that deregulation of apoptosis contributes to the development of human cancers. BAD, a proapoptotic Bcl-2 family protein, regulates the intrinsic apoptosis pathway. The aim of this study was to explore whether alterations of phospho-BAD (p-BAD) protein that antagonizes apoptosis function of BAD and mutation of BAD gene are characteristics of human gastric cancers. We analyzed expression of p-BAD in 60 gastric adenocarcinomas by immunohistochemistry. Also, we analyzed BAD gene for detection of somatic mutations by single-strand conformation polymorphism (SSCP) assay. p-BAD expression was detected well in normal gastric mucosal epithelial cells, whereas it was detected in only 51% (31 of the 60) of the cancers. There was no somatic mutation of BAD gene in the 60 gastric cancer samples. The decreased expression of p-BAD in malignant gastric epithelial cells compared to normal mucosal epithelial cells suggested that loss of p-BAD expression may play a role in gastric tumorigenesis. The data also suggest that BAD mutation may not be a direct target of inactivation in gastric tumorigenesis. | lld:pubmed |
| pubmed-article:17696955 | pubmed:language | eng | lld:pubmed |
| pubmed-article:17696955 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17696955 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:17696955 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17696955 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17696955 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:17696955 | pubmed:month | Aug | lld:pubmed |
| pubmed-article:17696955 | pubmed:issn | 0903-4641 | lld:pubmed |
| pubmed-article:17696955 | pubmed:author | pubmed-author:LeeSug... | lld:pubmed |
| pubmed-article:17696955 | pubmed:author | pubmed-author:YooNam JinNJ | lld:pubmed |
| pubmed-article:17696955 | pubmed:author | pubmed-author:KimSung SooSS | lld:pubmed |
| pubmed-article:17696955 | pubmed:author | pubmed-author:LeeSung HakSH | lld:pubmed |
| pubmed-article:17696955 | pubmed:author | pubmed-author:AhnChang... | lld:pubmed |
| pubmed-article:17696955 | pubmed:author | pubmed-author:JeongEun... | lld:pubmed |
| pubmed-article:17696955 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:17696955 | pubmed:volume | 115 | lld:pubmed |
| pubmed-article:17696955 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:17696955 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:17696955 | pubmed:pagination | 976-81 | lld:pubmed |
| pubmed-article:17696955 | pubmed:dateRevised | 2007-10-18 | lld:pubmed |
| pubmed-article:17696955 | pubmed:meshHeading | pubmed-meshheading:17696955... | lld:pubmed |
| pubmed-article:17696955 | pubmed:meshHeading | pubmed-meshheading:17696955... | lld:pubmed |
| pubmed-article:17696955 | pubmed:meshHeading | pubmed-meshheading:17696955... | lld:pubmed |
| pubmed-article:17696955 | pubmed:meshHeading | pubmed-meshheading:17696955... | lld:pubmed |
| pubmed-article:17696955 | pubmed:meshHeading | pubmed-meshheading:17696955... | lld:pubmed |
| pubmed-article:17696955 | pubmed:meshHeading | pubmed-meshheading:17696955... | lld:pubmed |
| pubmed-article:17696955 | pubmed:meshHeading | pubmed-meshheading:17696955... | lld:pubmed |
| pubmed-article:17696955 | pubmed:meshHeading | pubmed-meshheading:17696955... | lld:pubmed |
| pubmed-article:17696955 | pubmed:year | 2007 | lld:pubmed |
| pubmed-article:17696955 | pubmed:articleTitle | Immunohistochemical analysis of phospho-BAD protein and mutational analysis of BAD gene in gastric carcinomas. | lld:pubmed |
| pubmed-article:17696955 | pubmed:affiliation | Department of Pathology, College of Medicine, The Catholic University of Korea, Seoul, Korea. | lld:pubmed |
| pubmed-article:17696955 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:17696955 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| entrez-gene:572 | entrezgene:pubmed | pubmed-article:17696955 | lld:entrezgene |
| http://linkedlifedata.com/r... | entrezgene:pubmed | pubmed-article:17696955 | lld:entrezgene |
