Linked Life Data

17687115

Source:http://linkedlifedata.com/resource/pubmed/id/17687115

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pubmed-article:17687115pubmed:abstractTextThe GRIN3B gene encodes NR3B, a motoneuron-specific member of the NMDA type of ionotropic glutamate receptors. NR3B reduces the Ca(2+)-permeability as well as the overall current of the receptor response and may thereby protect motoneurons against glutamate-mediated excitotoxicity. We tested whether genetic dysfunction of GRIN3B is implicated in the pathogenesis of amyotrophic lateral sclerosis (ALS).lld:pubmed
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pubmed-article:17687115pubmed:articleTitleMotoneuron-specific NR3B gene: no association with ALS and evidence for a common null allele.lld:pubmed
pubmed-article:17687115pubmed:affiliationRIKEN-MIT Neuroscience Research Center, The Picower Institute for Learning and Memory, Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA, USA. Niemann.Stephan@gmail.comlld:pubmed
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