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pubmed-article:17675504pubmed:dateCreated2007-8-6lld:pubmed
pubmed-article:17675504pubmed:abstractTextThe BXSB strain of recombinant inbred mice develops a spontaneous pathology that closely resembles the human disease systemic lupus erythematosus. Six non-MHC loci, Yaa, Bxs1-4, and Bxs6, have been linked to the development of aspects of the disease while a further locus, Bxs5, may be a BXSB-derived disease suppressor. Disease development is delayed in a substrain of BXSB, BXSB/MpJScr-long-lived (BXSB/ll). We compared the genetic derivation of BXSB/ll mice to the original strain, BXSB/MpJ, using microsatellite markers and single nucleotide polymorphisms across the genome. These differences were clustered and included two regions known to be important in the disease-susceptibility of these mice, Bxs5 and 6, as well as regions on chromosomes 5, 6, 9, 11, 12, and 13. We compared BXSB/ll to >20 strains including the BXSB parental SB/Le and C57BL/6 strains. This revealed that BXSB/ll is a separate recombinant inbred line derived from SB/Le and C57BL/6, but distinctly different from BXSB, that most likely arose due to residual heterozygosity in the BXSB stock. Despite the continued presence of the powerful disease-susceptibility locus Bxs3, BXSB/ll mice do not develop disease. We propose that the disappearance of the disease phenotype in the BXSB/ll mice is due to the inheritance of one or more suppressor loci in the differentially inherited intervals between the BXSB/ll and BXSB strains.lld:pubmed
pubmed-article:17675504pubmed:languageenglld:pubmed
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pubmed-article:17675504pubmed:authorpubmed-author:IzuiShozoSlld:pubmed
pubmed-article:17675504pubmed:authorpubmed-author:HaywoodMichel...lld:pubmed
pubmed-article:17675504pubmed:authorpubmed-author:MorleyBernard...lld:pubmed
pubmed-article:17675504pubmed:authorpubmed-author:RogersNicola...lld:pubmed
pubmed-article:17675504pubmed:authorpubmed-author:RoseS JaneSJlld:pubmed
pubmed-article:17675504pubmed:authorpubmed-author:GabrielLuisaLlld:pubmed
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pubmed-article:17675504pubmed:pagination2428-34lld:pubmed
pubmed-article:17675504pubmed:dateRevised2008-11-21lld:pubmed
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pubmed-article:17675504pubmed:year2007lld:pubmed
pubmed-article:17675504pubmed:articleTitleBXSB/long-lived is a recombinant inbred strain containing powerful disease suppressor loci.lld:pubmed
pubmed-article:17675504pubmed:affiliationRheumatology Section, Imperial College, London, United Kingdom.lld:pubmed
pubmed-article:17675504pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:17675504pubmed:publicationTypeComparative Studylld:pubmed
pubmed-article:17675504pubmed:publicationTypeResearch Support, Non-U.S. Gov'tlld:pubmed
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