| pubmed-article:17667985 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:17667985 | lifeskim:mentions | umls-concept:C0011980 | lld:lifeskim |
| pubmed-article:17667985 | lifeskim:mentions | umls-concept:C1182789 | lld:lifeskim |
| pubmed-article:17667985 | lifeskim:mentions | umls-concept:C0662925 | lld:lifeskim |
| pubmed-article:17667985 | pubmed:issue | 8 | lld:pubmed |
| pubmed-article:17667985 | pubmed:dateCreated | 2007-10-4 | lld:pubmed |
| pubmed-article:17667985 | pubmed:abstractText | Ephs and ephrins are a family of membrane-bound proteins that function as receptor-ligand pairs. Members of the Eph-ephrin-B family have recently been reported to regulate the paracellular permeability of epithelial cells. In this study, we analyzed the expression and the function of ephrin-B1 in glomeruli. Using immunofluorescence (IF), we found that ephrin-B1 was expressed along the glomerular capillary loop. Immunoelectron microscopy revealed that ephrin-B1 expression was restricted at the slit diaphragm. Dual labeled IF showed ephrin-B1 colocalized with the slit diaphragm proteins nephrin and CD2-associated protein. Ephrin-B1 colocalized with nephrin at the late capillary loop stage of kidney development. Additionally, injection of rats with a nephritogenic anti-nephrin antibody (ANA) reduced ephrin-B1 expression. When podocytes were cultured in vitro, they extruded processes that co-stained for ephrin-B1 and for CD2-associated protein. When these podocytes were treated in culture with small interfering RNA for ephrin-B1, CD2-associated protein was reduced in the processes, with a remaining faint perinuclear staining. We suggest that ephrin-B1 has a role in maintaining barrier function at the slit diaphragm. | lld:pubmed |
| pubmed-article:17667985 | pubmed:language | eng | lld:pubmed |
| pubmed-article:17667985 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17667985 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:17667985 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:17667985 | pubmed:month | Oct | lld:pubmed |
| pubmed-article:17667985 | pubmed:issn | 0085-2538 | lld:pubmed |
| pubmed-article:17667985 | pubmed:author | pubmed-author:HashimotoTT | lld:pubmed |
| pubmed-article:17667985 | pubmed:author | pubmed-author:HayasakaKK | lld:pubmed |
| pubmed-article:17667985 | pubmed:author | pubmed-author:SaitoAA | lld:pubmed |
| pubmed-article:17667985 | pubmed:author | pubmed-author:KarasawaTT | lld:pubmed |
| pubmed-article:17667985 | pubmed:author | pubmed-author:ShimizuFF | lld:pubmed |
| pubmed-article:17667985 | pubmed:author | pubmed-author:MiyauchiNN | lld:pubmed |
| pubmed-article:17667985 | pubmed:author | pubmed-author:KawachiHH | lld:pubmed |
| pubmed-article:17667985 | pubmed:author | pubmed-author:HamG CGC | lld:pubmed |
| pubmed-article:17667985 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:17667985 | pubmed:volume | 72 | lld:pubmed |
| pubmed-article:17667985 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:17667985 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:17667985 | pubmed:pagination | 954-64 | lld:pubmed |
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| pubmed-article:17667985 | pubmed:year | 2007 | lld:pubmed |
| pubmed-article:17667985 | pubmed:articleTitle | Ephrin-B1 localizes at the slit diaphragm of the glomerular podocyte. | lld:pubmed |
| pubmed-article:17667985 | pubmed:affiliation | Department of Cell Biology, Institute of Nephrology, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan. | lld:pubmed |
| pubmed-article:17667985 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:17667985 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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