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pubmed-article:17664321pubmed:abstractTextACC-4, an omega loop mutant (Val(211)-->Gly) of the Hafnia alvei-derived cephalosporinase ACC-1, was encoded by an Escherichia coli plasmid. The genetic environment of bla(ACC-4) shared similarities with plasmidic regions carrying bla(ACC-1). Kinetics of beta-lactam hydrolysis and levels of resistance to beta-lactams showed that ACC-4 was more effective than ACC-1 against expanded-spectrum cephalosporins.lld:pubmed
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pubmed-article:17664321pubmed:articleTitlePlasmid-encoded ACC-4, an extended-spectrum cephalosporinase variant from Escherichia coli.lld:pubmed
pubmed-article:17664321pubmed:affiliationLaboratory of Bacteriology, Hellenic Pasteur Institute, Vas Sofias 127, Athens, Greece.lld:pubmed
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