Septic reactions continue to be reported with culture-tested platelet (PLT) products, probably due to false-negative results associated with inadequate sampling of low-concentration bacteria. The mechanism of test failure was modeled and false-negative rates were estimated utilizing published data.
The residual risk of sepsis: modeling the effect of concentration on bacterial detection in two-bottle culture systems and an estimation of false-negative culture rates.
Biomedical Services, Medical Office, National Headquarters, American Red Cross, 2025 E Street NW, Washington, DC 20006, USA. BenjaminR@usa.redcross.org
