| pubmed-article:17638655 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:17638655 | lifeskim:mentions | umls-concept:C0263396 | lld:lifeskim |
| pubmed-article:17638655 | lifeskim:mentions | umls-concept:C0008902 | lld:lifeskim |
| pubmed-article:17638655 | lifeskim:mentions | umls-concept:C1513392 | lld:lifeskim |
| pubmed-article:17638655 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:17638655 | pubmed:dateCreated | 2007-7-19 | lld:pubmed |
| pubmed-article:17638655 | pubmed:abstractText | The categorization of pigmented purpuric dermatosis (PPD) as a form of cutaneous lymphoid dyscrasia has been suggested. Phenotypic and molecular studies were done on 43 patients with PPD. The molecular studies used a capillary gel electrophoresis T-cell receptor beta multiplex polymerase chain reaction assay. There were 2 principal categories: polyclonal PPD represented by 22 cases and monoclonal variants comprising 21 cases. Monoclonal cases had extensive skin lesions. An identical restricted T-cell repertoire independent of time and location was observed. Approximately 40% of the monoclonal cases had clinical and pathologic features of mycosis fungoides (MF). In the polyclonal variant, disease outside the lower extremities was uncommon; there were no patients with MF. Striking reductions in CD7 and CD62L were seen in both groups. PPD is a form of cutaneous T-cell lymphoid dyscrasia, based on the frequency of monoclonality, the preservation of persistent T-cell clonotypes, and extent of pan-T-cell marker loss. Stratification of lesions of PPD according to the molecular profile may be of significant value prognostically and influence therapeutic intervention. | lld:pubmed |
| pubmed-article:17638655 | pubmed:language | eng | lld:pubmed |
| pubmed-article:17638655 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17638655 | pubmed:citationSubset | AIM | lld:pubmed |
| pubmed-article:17638655 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17638655 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17638655 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:17638655 | pubmed:month | Aug | lld:pubmed |
| pubmed-article:17638655 | pubmed:issn | 0002-9173 | lld:pubmed |
| pubmed-article:17638655 | pubmed:author | pubmed-author:CrowsonA... | lld:pubmed |
| pubmed-article:17638655 | pubmed:author | pubmed-author:MagroCynthia... | lld:pubmed |
| pubmed-article:17638655 | pubmed:author | pubmed-author:MorrisonCarlC | lld:pubmed |
| pubmed-article:17638655 | pubmed:author | pubmed-author:LiJingweiJ | lld:pubmed |
| pubmed-article:17638655 | pubmed:author | pubmed-author:SchaeferJoche... | lld:pubmed |
| pubmed-article:17638655 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:17638655 | pubmed:volume | 128 | lld:pubmed |
| pubmed-article:17638655 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:17638655 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:17638655 | pubmed:pagination | 218-29 | lld:pubmed |
| pubmed-article:17638655 | pubmed:meshHeading | pubmed-meshheading:17638655... | lld:pubmed |
| pubmed-article:17638655 | pubmed:meshHeading | pubmed-meshheading:17638655... | lld:pubmed |
| pubmed-article:17638655 | pubmed:meshHeading | pubmed-meshheading:17638655... | lld:pubmed |
| pubmed-article:17638655 | pubmed:meshHeading | pubmed-meshheading:17638655... | lld:pubmed |
| pubmed-article:17638655 | pubmed:meshHeading | pubmed-meshheading:17638655... | lld:pubmed |
| pubmed-article:17638655 | pubmed:meshHeading | pubmed-meshheading:17638655... | lld:pubmed |
| pubmed-article:17638655 | pubmed:meshHeading | pubmed-meshheading:17638655... | lld:pubmed |
| pubmed-article:17638655 | pubmed:meshHeading | pubmed-meshheading:17638655... | lld:pubmed |
| pubmed-article:17638655 | pubmed:meshHeading | pubmed-meshheading:17638655... | lld:pubmed |
| pubmed-article:17638655 | pubmed:meshHeading | pubmed-meshheading:17638655... | lld:pubmed |
| pubmed-article:17638655 | pubmed:meshHeading | pubmed-meshheading:17638655... | lld:pubmed |
| pubmed-article:17638655 | pubmed:meshHeading | pubmed-meshheading:17638655... | lld:pubmed |
| pubmed-article:17638655 | pubmed:meshHeading | pubmed-meshheading:17638655... | lld:pubmed |
| pubmed-article:17638655 | pubmed:meshHeading | pubmed-meshheading:17638655... | lld:pubmed |
| pubmed-article:17638655 | pubmed:meshHeading | pubmed-meshheading:17638655... | lld:pubmed |
| pubmed-article:17638655 | pubmed:year | 2007 | lld:pubmed |
| pubmed-article:17638655 | pubmed:articleTitle | Pigmented purpuric dermatosis: classification by phenotypic and molecular profiles. | lld:pubmed |
| pubmed-article:17638655 | pubmed:affiliation | Department of Pathology and Laboratory Medicine, Weill Medical College of Cornell University New York Presbyterian Hospital-Cornell Campus, New York, NY 10021, USA. | lld:pubmed |
| pubmed-article:17638655 | pubmed:publicationType | Journal Article | lld:pubmed |
