| pubmed-article:17628611 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:17628611 | lifeskim:mentions | umls-concept:C0001554 | lld:lifeskim |
| pubmed-article:17628611 | lifeskim:mentions | umls-concept:C0007603 | lld:lifeskim |
| pubmed-article:17628611 | lifeskim:mentions | umls-concept:C1882687 | lld:lifeskim |
| pubmed-article:17628611 | lifeskim:mentions | umls-concept:C0004147 | lld:lifeskim |
| pubmed-article:17628611 | lifeskim:mentions | umls-concept:C0033497 | lld:lifeskim |
| pubmed-article:17628611 | lifeskim:mentions | umls-concept:C0392747 | lld:lifeskim |
| pubmed-article:17628611 | lifeskim:mentions | umls-concept:C0053532 | lld:lifeskim |
| pubmed-article:17628611 | lifeskim:mentions | umls-concept:C0205191 | lld:lifeskim |
| pubmed-article:17628611 | pubmed:issue | 5 | lld:pubmed |
| pubmed-article:17628611 | pubmed:dateCreated | 2007-7-24 | lld:pubmed |
| pubmed-article:17628611 | pubmed:abstractText | Recently, tissue segment binding method with a hydrophilic radioligand [(3)H]-CGP12177 was developed to detect plasma membrane beta-adrenoceptors in rat heart (Horinouchi et al., 2006). In the present study, propranolol (40 mg kg(-1) day(-1)), atenolol (40 mg kg(-1) day(-1)) and bevantolol (200 mg kg(-1) day(-1)) were administered to rats for 6 weeks, and the changes of plasma membrane beta-adrenoceptors and their mRNA expression in rat ventricle were examined. Chronic administration of propranolol increased the beta(1)-adrenoceptors but decreased the beta(2)-adrenoceptors without changing total amount of plasma membrane beta-adrenoceptors. Atenolol increased both plasma membrane beta(1)- and beta(2)-adrenoceptors, whereas bevantolol had no effect on the beta-adrenoceptor density and their subtype proportions. In contrast, the density of beta-adrenoceptors detected in conventional homogenate binding study was extremely low (approximately 60% of plasma membrane beta-adrenoceptors detected with the tissue segment binding method) and the effects of chronic administration of beta-adrenoceptor antagonists were not necessarily in accord with those at the plasma membrane beta-adrenoceptors. The mRNA levels of beta(1)- and beta(2)-adrenoceptors were not altered by propranolol treatment, while beta(1)-adrenoceptor mRNA significantly decreased after administration of atenolol or bevantolol without changing the level of beta(2)-adrenoceptor mRNA. The present binding study with intact tissue segments clearly shows that the plasma membrane beta(1)- and beta(2)-adrenoceptors of rat heart, in contrast to the homogenate binding sites and the mRNA levels, are differently affected by chronic treatment with three beta-adrenoceptor antagonists; up- and down-regulations of beta(1)- and beta(2)-adrenoceptors, respectively, by propranolol, and up-regulation of both the subtypes by atenolol, but no significant change in both the subtypes by bevantolol. | lld:pubmed |
| pubmed-article:17628611 | pubmed:language | eng | lld:pubmed |
| pubmed-article:17628611 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17628611 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:17628611 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17628611 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17628611 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17628611 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17628611 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17628611 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17628611 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:17628611 | pubmed:month | Jul | lld:pubmed |
| pubmed-article:17628611 | pubmed:issn | 0024-3205 | lld:pubmed |
| pubmed-article:17628611 | pubmed:author | pubmed-author:SuzukiFumikoF | lld:pubmed |
| pubmed-article:17628611 | pubmed:author | pubmed-author:TanakaYoshioY | lld:pubmed |
| pubmed-article:17628611 | pubmed:author | pubmed-author:TanakaTakashi... | lld:pubmed |
| pubmed-article:17628611 | pubmed:author | pubmed-author:MiwaSoichiS | lld:pubmed |
| pubmed-article:17628611 | pubmed:author | pubmed-author:MuramatsuIkun... | lld:pubmed |
| pubmed-article:17628611 | pubmed:author | pubmed-author:KoikeKatsuoK | lld:pubmed |
| pubmed-article:17628611 | pubmed:author | pubmed-author:HorinouchiTak... | lld:pubmed |
| pubmed-article:17628611 | pubmed:author | pubmed-author:MorishimaShig... | lld:pubmed |
| pubmed-article:17628611 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:17628611 | pubmed:day | 12 | lld:pubmed |
| pubmed-article:17628611 | pubmed:volume | 81 | lld:pubmed |
| pubmed-article:17628611 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:17628611 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:17628611 | pubmed:pagination | 399-404 | lld:pubmed |
| pubmed-article:17628611 | pubmed:meshHeading | pubmed-meshheading:17628611... | lld:pubmed |
| pubmed-article:17628611 | pubmed:meshHeading | pubmed-meshheading:17628611... | lld:pubmed |
| pubmed-article:17628611 | pubmed:meshHeading | pubmed-meshheading:17628611... | lld:pubmed |
| pubmed-article:17628611 | pubmed:meshHeading | pubmed-meshheading:17628611... | lld:pubmed |
| pubmed-article:17628611 | pubmed:meshHeading | pubmed-meshheading:17628611... | lld:pubmed |
| pubmed-article:17628611 | pubmed:meshHeading | pubmed-meshheading:17628611... | lld:pubmed |
| pubmed-article:17628611 | pubmed:meshHeading | pubmed-meshheading:17628611... | lld:pubmed |
| pubmed-article:17628611 | pubmed:meshHeading | pubmed-meshheading:17628611... | lld:pubmed |
| pubmed-article:17628611 | pubmed:meshHeading | pubmed-meshheading:17628611... | lld:pubmed |
| pubmed-article:17628611 | pubmed:meshHeading | pubmed-meshheading:17628611... | lld:pubmed |
| pubmed-article:17628611 | pubmed:year | 2007 | lld:pubmed |
| pubmed-article:17628611 | pubmed:articleTitle | Different changes of plasma membrane beta-adrenoceptors in rat heart after chronic administration of propranolol, atenolol and bevantolol. | lld:pubmed |
| pubmed-article:17628611 | pubmed:affiliation | Division of Pharmacology, Department of Biochemistry and Bioinformative Sciences, School of Medicine, University of Fukui, Fukui 910-1193, Japan. | lld:pubmed |
| pubmed-article:17628611 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:17628611 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
