| pubmed-article:17618854 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:17618854 | lifeskim:mentions | umls-concept:C0206588 | lld:lifeskim |
| pubmed-article:17618854 | lifeskim:mentions | umls-concept:C0205245 | lld:lifeskim |
| pubmed-article:17618854 | lifeskim:mentions | umls-concept:C0428876 | lld:lifeskim |
| pubmed-article:17618854 | lifeskim:mentions | umls-concept:C0388148 | lld:lifeskim |
| pubmed-article:17618854 | lifeskim:mentions | umls-concept:C1414463 | lld:lifeskim |
| pubmed-article:17618854 | lifeskim:mentions | umls-concept:C0392673 | lld:lifeskim |
| pubmed-article:17618854 | lifeskim:mentions | umls-concept:C0005486 | lld:lifeskim |
| pubmed-article:17618854 | lifeskim:mentions | umls-concept:C1546857 | lld:lifeskim |
| pubmed-article:17618854 | lifeskim:mentions | umls-concept:C1556066 | lld:lifeskim |
| pubmed-article:17618854 | lifeskim:mentions | umls-concept:C1619636 | lld:lifeskim |
| pubmed-article:17618854 | lifeskim:mentions | umls-concept:C1514873 | lld:lifeskim |
| pubmed-article:17618854 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:17618854 | pubmed:dateCreated | 2007-7-9 | lld:pubmed |
| pubmed-article:17618854 | pubmed:abstractText | Downregulation and functional deactivation of the transcriptional coactivator PGC-1alpha has been implicated in heart failure pathogenesis. We hypothesized that the estrogen-related receptor alpha (ERRalpha), which recruits PGC-1alpha to metabolic target genes in heart, exerts protective effects in the context of stressors known to cause heart failure. ERRalpha(-/-) mice subjected to left ventricular (LV) pressure overload developed signatures of heart failure including chamber dilatation and reduced LV fractional shortening. (31)P-NMR studies revealed abnormal phosphocreatine depletion in ERRalpha(-/-) hearts subjected to hemodynamic stress, indicative of a defect in ATP reserve. Mitochondrial respiration studies demonstrated reduced maximal ATP synthesis rates in ERRalpha(-/-) hearts. Cardiac ERRalpha target genes involved in energy substrate oxidation, ATP synthesis, and phosphate transfer were downregulated in ERRalpha(-/-) mice at baseline or with pressure overload. These results demonstrate that the nuclear receptor ERRalpha is required for the adaptive bioenergetic response to hemodynamic stressors known to cause heart failure. | lld:pubmed |
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| pubmed-article:17618854 | pubmed:language | eng | lld:pubmed |
| pubmed-article:17618854 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17618854 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:17618854 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:17618854 | pubmed:month | Jul | lld:pubmed |
| pubmed-article:17618854 | pubmed:issn | 1550-4131 | lld:pubmed |
| pubmed-article:17618854 | pubmed:author | pubmed-author:KellyDaniel... | lld:pubmed |
| pubmed-article:17618854 | pubmed:author | pubmed-author:WeinheimerCar... | lld:pubmed |
| pubmed-article:17618854 | pubmed:author | pubmed-author:MurphyElizabe... | lld:pubmed |
| pubmed-article:17618854 | pubmed:author | pubmed-author:HussJanice... | lld:pubmed |
| pubmed-article:17618854 | pubmed:author | pubmed-author:GiguèreVincen... | lld:pubmed |
| pubmed-article:17618854 | pubmed:author | pubmed-author:KovacsAtillaA | lld:pubmed |
| pubmed-article:17618854 | pubmed:author | pubmed-author:CourtoisMicha... | lld:pubmed |
| pubmed-article:17618854 | pubmed:author | pubmed-author:ImahashiKen-i... | lld:pubmed |
| pubmed-article:17618854 | pubmed:author | pubmed-author:DufourCatheri... | lld:pubmed |
| pubmed-article:17618854 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:17618854 | pubmed:volume | 6 | lld:pubmed |
| pubmed-article:17618854 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:17618854 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:17618854 | pubmed:pagination | 25-37 | lld:pubmed |
| pubmed-article:17618854 | pubmed:dateRevised | 2011-5-13 | lld:pubmed |
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| pubmed-article:17618854 | pubmed:year | 2007 | lld:pubmed |
| pubmed-article:17618854 | pubmed:articleTitle | The nuclear receptor ERRalpha is required for the bioenergetic and functional adaptation to cardiac pressure overload. | lld:pubmed |
| pubmed-article:17618854 | pubmed:affiliation | Center for Cardiovascular Research, Washington University School of Medicine, St. Louis, MO 63110, USA. | lld:pubmed |
| pubmed-article:17618854 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:17618854 | pubmed:publicationType | Research Support, N.I.H., Extramural | lld:pubmed |
| pubmed-article:17618854 | pubmed:publicationType | Research Support, N.I.H., Intramural | lld:pubmed |
| entrez-gene:26379 | entrezgene:pubmed | pubmed-article:17618854 | lld:entrezgene |
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