| pubmed-article:17612498 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:17612498 | lifeskim:mentions | umls-concept:C0162741 | lld:lifeskim |
| pubmed-article:17612498 | lifeskim:mentions | umls-concept:C1551714 | lld:lifeskim |
| pubmed-article:17612498 | lifeskim:mentions | umls-concept:C0085187 | lld:lifeskim |
| pubmed-article:17612498 | lifeskim:mentions | umls-concept:C1522492 | lld:lifeskim |
| pubmed-article:17612498 | lifeskim:mentions | umls-concept:C1523987 | lld:lifeskim |
| pubmed-article:17612498 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:17612498 | pubmed:dateCreated | 2007-7-6 | lld:pubmed |
| pubmed-article:17612498 | pubmed:abstractText | Telomeres in mammals and plants are protected by the terminal t loop structure, the formation of which parallels the first steps of intrachromatid homologous recombination (HR). Under some circumstances, cells can also utilize an HR-based mechanism (alternative lengthening of telomeres [ALT]) as a back-up pathway for telomere maintenance. We have found that the Ku70/80 heterodimer, a central nonhomologous end-joining DNA repair factor, inhibits engagement of ALT in Arabidopsis telomerase-negative cells. To further assess HR activities at telomeres, we have developed a sensitive assay for detecting extrachromosomal telomeric circles (t circles) that may arise from t loop resolution and aberrant HR. We show that Ku70/80 specifically inhibits circle formation at telomeres, but not at centromeric and rDNA repeats. Ku inactivation results in increased formation of t circles that represent approximately 4% of total telomeric DNA. However, telomeres in ku mutants are fully functional, indicating that telomerase efficiently heals ongoing terminal deletions arising from excision of the t circles. | lld:pubmed |
| pubmed-article:17612498 | pubmed:language | eng | lld:pubmed |
| pubmed-article:17612498 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17612498 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:17612498 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17612498 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:17612498 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:17612498 | pubmed:month | Jul | lld:pubmed |
| pubmed-article:17612498 | pubmed:issn | 1097-2765 | lld:pubmed |
| pubmed-article:17612498 | pubmed:author | pubmed-author:RihaKarelK | lld:pubmed |
| pubmed-article:17612498 | pubmed:author | pubmed-author:PuizinaJasnaJ | lld:pubmed |
| pubmed-article:17612498 | pubmed:author | pubmed-author:AkimchevaSvet... | lld:pubmed |
| pubmed-article:17612498 | pubmed:author | pubmed-author:ZellingerBarb... | lld:pubmed |
| pubmed-article:17612498 | pubmed:author | pubmed-author:SchiratoMarti... | lld:pubmed |
| pubmed-article:17612498 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:17612498 | pubmed:day | 6 | lld:pubmed |
| pubmed-article:17612498 | pubmed:volume | 27 | lld:pubmed |
| pubmed-article:17612498 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:17612498 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:17612498 | pubmed:pagination | 163-9 | lld:pubmed |
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| pubmed-article:17612498 | pubmed:meshHeading | pubmed-meshheading:17612498... | lld:pubmed |
| pubmed-article:17612498 | pubmed:meshHeading | pubmed-meshheading:17612498... | lld:pubmed |
| pubmed-article:17612498 | pubmed:year | 2007 | lld:pubmed |
| pubmed-article:17612498 | pubmed:articleTitle | Ku suppresses formation of telomeric circles and alternative telomere lengthening in Arabidopsis. | lld:pubmed |
| pubmed-article:17612498 | pubmed:affiliation | Gregor Mendel Institute of Molecular Plant Biology, Austrian Academy of Sciences, 1030 Vienna, Austria. | lld:pubmed |
| pubmed-article:17612498 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:17612498 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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