| pubmed-article:17600728 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:17600728 | lifeskim:mentions | umls-concept:C0006104 | lld:lifeskim |
| pubmed-article:17600728 | lifeskim:mentions | umls-concept:C0023175 | lld:lifeskim |
| pubmed-article:17600728 | lifeskim:mentions | umls-concept:C0086582 | lld:lifeskim |
| pubmed-article:17600728 | lifeskim:mentions | umls-concept:C0332157 | lld:lifeskim |
| pubmed-article:17600728 | lifeskim:mentions | umls-concept:C0869014 | lld:lifeskim |
| pubmed-article:17600728 | lifeskim:mentions | umls-concept:C0392335 | lld:lifeskim |
| pubmed-article:17600728 | lifeskim:mentions | umls-concept:C0439234 | lld:lifeskim |
| pubmed-article:17600728 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:17600728 | pubmed:dateCreated | 2007-7-30 | lld:pubmed |
| pubmed-article:17600728 | pubmed:abstractText | We examined relations between brain volumes assessed by MRI and cognitive function in subjects in whom we have previously reported associations of cumulative lead dose with: (1) longitudinal declines in cognitive function; (2) smaller volumes of several regions of interest (ROIs) in the brain; and (3) increased prevalence and severity of white matter lesions. We used two complementary methods (ROI- [evaluating 20 ROIs] and voxel-wise) to examine associations between brain volumes and cognitive function using multiple linear regression. MRIs and cognitive testing were obtained from 532 former organolead workers with a mean (SD) age of 56.1 (7.7) years and a mean of 18.0 (11.0) years since the last occupational exposure to lead at the time of MRI acquisition. Cognitive testing was grouped into six domains of function (visuo-construction, verbal memory and learning, visual memory, executive functioning, eye-hand coordination, processing speed). Results indicated that larger ROI volumes were associated with better cognitive function in five of six cognitive domains, with significant associations observed for visuo-construction (15 of 20, p<or=0.05), processing speed (12, p<or=0.05), visual memory (11, p<or=0.05), executive functioning (11, p<or=0.05), and eye-hand coordination (11, p<or=0.05). Significant structure-function relations were also identified in the voxel-wise analysis with low false discovery rates (all less than 2.2%). Thus, larger volumes were associated with better cognitive function using both ROI- and voxel-based methods. In this cohort, an interesting group in which to examine structure-function relations, this finding provides a necessary condition to support the hypothesis that lead may influence cognitive function by its effect on brain volumes. | lld:pubmed |
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| pubmed-article:17600728 | pubmed:language | eng | lld:pubmed |
| pubmed-article:17600728 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17600728 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:17600728 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17600728 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:17600728 | pubmed:month | Aug | lld:pubmed |
| pubmed-article:17600728 | pubmed:issn | 1053-8119 | lld:pubmed |
| pubmed-article:17600728 | pubmed:author | pubmed-author:DavatzikosChr... | lld:pubmed |
| pubmed-article:17600728 | pubmed:author | pubmed-author:BollaKaren... | lld:pubmed |
| pubmed-article:17600728 | pubmed:author | pubmed-author:StewartWalter... | lld:pubmed |
| pubmed-article:17600728 | pubmed:author | pubmed-author:SchwartzBrian... | lld:pubmed |
| pubmed-article:17600728 | pubmed:author | pubmed-author:YousemDavidD | lld:pubmed |
| pubmed-article:17600728 | pubmed:author | pubmed-author:ChenSiningS | lld:pubmed |
| pubmed-article:17600728 | pubmed:author | pubmed-author:CaffoBrianB | lld:pubmed |
| pubmed-article:17600728 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:17600728 | pubmed:day | 15 | lld:pubmed |
| pubmed-article:17600728 | pubmed:volume | 37 | lld:pubmed |
| pubmed-article:17600728 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:17600728 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:17600728 | pubmed:pagination | 633-41 | lld:pubmed |
| pubmed-article:17600728 | pubmed:dateRevised | 2011-9-26 | lld:pubmed |
| pubmed-article:17600728 | pubmed:meshHeading | pubmed-meshheading:17600728... | lld:pubmed |
| pubmed-article:17600728 | pubmed:meshHeading | pubmed-meshheading:17600728... | lld:pubmed |
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| pubmed-article:17600728 | pubmed:meshHeading | pubmed-meshheading:17600728... | lld:pubmed |
| pubmed-article:17600728 | pubmed:year | 2007 | lld:pubmed |
| pubmed-article:17600728 | pubmed:articleTitle | Relations of brain volumes with cognitive function in males 45 years and older with past lead exposure. | lld:pubmed |
| pubmed-article:17600728 | pubmed:affiliation | Department of Environmental Health Sciences, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA. bschwart@jhsph.edu | lld:pubmed |
| pubmed-article:17600728 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:17600728 | pubmed:publicationType | Research Support, N.I.H., Extramural | lld:pubmed |
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