| pubmed-article:17600560 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:17600560 | lifeskim:mentions | umls-concept:C0330390 | lld:lifeskim |
| pubmed-article:17600560 | lifeskim:mentions | umls-concept:C1882687 | lld:lifeskim |
| pubmed-article:17600560 | lifeskim:mentions | umls-concept:C0034783 | lld:lifeskim |
| pubmed-article:17600560 | lifeskim:mentions | umls-concept:C0205245 | lld:lifeskim |
| pubmed-article:17600560 | pubmed:issue | 8 | lld:pubmed |
| pubmed-article:17600560 | pubmed:dateCreated | 2007-6-29 | lld:pubmed |
| pubmed-article:17600560 | pubmed:abstractText | 1. beta(3)-Adrenoceptors (AR) have been reported to be present in numerous species, where they mediate multiple responses. 2. The aim of the present study was to determine whether beta(3)-AR are present in intact rat heart and the functional implications of beta(3)-AR stimulation. The response to the cardiac beta(3)-AR-selective agonist BRL37344 was expressed as the percentage of values measured at baseline. 3. BRL37344 induced dose-dependent negative inotropic effects at concentrations ranging from 10(-11) to 10(-7) mol/L. BRL37344 (10(-8) mol/L) induced a decrease of left ventricular developed pressure (LVDP) from 127 +/- 5 to 89 +/- 16 mmHg (69 +/- 15%; P < 0.01) and +dP/dt from 2594 +/- 59 to 1885 +/- 50 mmHg/s (72 +/- 8%; P < 0.01). Moreover, a significant reduction of -dP/dt from 2176 +/- 42 to 1458 +/- 43 mmHg/s (67 +/- 8%; P < 0.01) was observed. The BRL37344 dose-response curves were not altered by nadolol (10(-5) mol/L), a potent beta(1)- and beta(2)-AR antagonist, but were completely suppressed by the addition of SR59230A (10(-5) mol/L), a potent beta(3)-AR antagonist. 4. The present study provides functional evidence for the presence of beta(3)-AR in rat hearts and shows, for the first time, that a highly specific beta(3)-AR antagonist can block the attenuation of LVDP caused by the specific beta(3)-AR agonist BRL37344 in rat beating hearts. | lld:pubmed |
| pubmed-article:17600560 | pubmed:language | eng | lld:pubmed |
| pubmed-article:17600560 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17600560 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:17600560 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17600560 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17600560 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17600560 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17600560 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17600560 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17600560 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17600560 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:17600560 | pubmed:month | Aug | lld:pubmed |
| pubmed-article:17600560 | pubmed:issn | 0305-1870 | lld:pubmed |
| pubmed-article:17600560 | pubmed:author | pubmed-author:BarbierJJ | lld:pubmed |
| pubmed-article:17600560 | pubmed:author | pubmed-author:CarréFF | lld:pubmed |
| pubmed-article:17600560 | pubmed:author | pubmed-author:MouasCC | lld:pubmed |
| pubmed-article:17600560 | pubmed:author | pubmed-author:Rannou-Bekono... | lld:pubmed |
| pubmed-article:17600560 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:17600560 | pubmed:volume | 34 | lld:pubmed |
| pubmed-article:17600560 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:17600560 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:17600560 | pubmed:pagination | 796-8 | lld:pubmed |
| pubmed-article:17600560 | pubmed:dateRevised | 2010-11-18 | lld:pubmed |
| pubmed-article:17600560 | pubmed:meshHeading | pubmed-meshheading:17600560... | lld:pubmed |
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| pubmed-article:17600560 | pubmed:meshHeading | pubmed-meshheading:17600560... | lld:pubmed |
| pubmed-article:17600560 | pubmed:meshHeading | pubmed-meshheading:17600560... | lld:pubmed |
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| pubmed-article:17600560 | pubmed:meshHeading | pubmed-meshheading:17600560... | lld:pubmed |
| pubmed-article:17600560 | pubmed:year | 2007 | lld:pubmed |
| pubmed-article:17600560 | pubmed:articleTitle | Existence of beta(3)-adrenoceptors in rat heart: functional implications. | lld:pubmed |
| pubmed-article:17600560 | pubmed:affiliation | EA 1274, Laboratory of Physiology and Biomechanics of Muscular Exercise, UFR-APS, University of Rennes 2, Rennes, France. julie.barbier@uhb.fr | lld:pubmed |
| pubmed-article:17600560 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:17600560 | pubmed:publicationType | In Vitro | lld:pubmed |
| entrez-gene:25645 | entrezgene:pubmed | pubmed-article:17600560 | lld:entrezgene |
| http://linkedlifedata.com/r... | entrezgene:pubmed | pubmed-article:17600560 | lld:entrezgene |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:17600560 | lld:pubmed |
