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pubmed-article:1757943pubmed:abstractTextThe risk of iridocyclitis in children with early onset pauciarticular juvenile rheumatoid arthritis (EOPA-JRA) has been shown to be associated with certain HLA haplotypes. Our report contains an actuarial analysis, using one-year intervals, of 161 subjects and estimates haplotype specific risks. Individuals who possess the major susceptibility haplotype HLA-DR5 (11) developed eye disease earlier and with a greater frequency than did those with the protective HLA-DR1 haplotype. Highly significant differences were found between the resulting life-table curves for HLA-DR5 and HLA-DR1 positive subjects (p = 0.00003). These time oriented risk estimates may aid clinicians in determining more precisely the probability of iridocyclitis throughout the course of the disease in children with EOPA-JRA.lld:pubmed
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pubmed-article:1757943pubmed:dateRevised2007-11-14lld:pubmed
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pubmed-article:1757943pubmed:articleTitleLongitudinal analysis of HLA associated risks for iridocyclitis in juvenile rheumatoid arthritis.lld:pubmed
pubmed-article:1757943pubmed:affiliationDivision of Rheumatology, Children's Hospital Medical Center, Cincinnati, OH 45229.lld:pubmed
pubmed-article:1757943pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:1757943pubmed:publicationTypeResearch Support, U.S. Gov't, P.H.S.lld:pubmed
pubmed-article:1757943pubmed:publicationTypeResearch Support, Non-U.S. Gov'tlld:pubmed
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