pubmed-article:17575071 | rdf:type | pubmed:Citation | lld:pubmed |
pubmed-article:17575071 | lifeskim:mentions | umls-concept:C1416467 | lld:lifeskim |
pubmed-article:17575071 | lifeskim:mentions | umls-concept:C1420812 | lld:lifeskim |
pubmed-article:17575071 | lifeskim:mentions | umls-concept:C0541749 | lld:lifeskim |
pubmed-article:17575071 | pubmed:issue | 7 | lld:pubmed |
pubmed-article:17575071 | pubmed:dateCreated | 2007-9-20 | lld:pubmed |
pubmed-article:17575071 | pubmed:abstractText | OX40 is a recently identified T-cell costimulatory molecule that belongs to the TNF/TNFR superfamily. OX40 can be expressed by both activated T effector cells and Foxp3(+) Tregs. It is well known that OX40 delivers a potent costimulatory signal to T effector cells, but very little is known about the role of OX40 in regulating the suppressor properties of Foxp3(+) Tregs and the de novo generation of new inducible Foxp3(+) Tregs from T effector cells. In the present study, we found, by using a newly created foxp3gfp knockin model, that OX40 was dispensable for the genesis and suppressor functions of naturally arising CD4(+)Foxp3(+) Tregs, but stimulating OX40 on the Foxp3(+) Tregs abrogated their ability to suppress T effector cell proliferation, IFN-gamma production, and T effector cell-mediated allograft rejection. OX40 costimulation did not significantly affect proliferation and survival of the naturally arising Foxp3(+) Tregs, but profoundly inhibited Foxp3 gene expression. Importantly, OX40 costimulation to T effector cells prevented the induction of new inducible Foxp3(+) Tregs from T effector cells. Our study identified OX40 as a key negative regulator of Foxp3(+) Tregs and may have important clinical implications in models of transplantation and autoimmunity. | lld:pubmed |
pubmed-article:17575071 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:17575071 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:17575071 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:17575071 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:17575071 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:17575071 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:17575071 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:17575071 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:17575071 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:17575071 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:17575071 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:17575071 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:17575071 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:17575071 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:17575071 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:17575071 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:17575071 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:17575071 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:17575071 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:17575071 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:17575071 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:17575071 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:17575071 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:17575071 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:17575071 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:17575071 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:17575071 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:17575071 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:17575071 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:17575071 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:17575071 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:17575071 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:17575071 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:17575071 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:17575071 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:17575071 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:17575071 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:17575071 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:17575071 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:17575071 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:17575071 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:17575071 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:17575071 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:17575071 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:17575071 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:17575071 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:17575071 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:17575071 | pubmed:language | eng | lld:pubmed |
pubmed-article:17575071 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:17575071 | pubmed:citationSubset | AIM | lld:pubmed |
pubmed-article:17575071 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:17575071 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:17575071 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:17575071 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:17575071 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:17575071 | pubmed:status | MEDLINE | lld:pubmed |
pubmed-article:17575071 | pubmed:month | Oct | lld:pubmed |
pubmed-article:17575071 | pubmed:issn | 0006-4971 | lld:pubmed |
pubmed-article:17575071 | pubmed:author | pubmed-author:IshiiNaotoN | lld:pubmed |
pubmed-article:17575071 | pubmed:author | pubmed-author:GaoWendaW | lld:pubmed |
pubmed-article:17575071 | pubmed:author | pubmed-author:ChenMingM | lld:pubmed |
pubmed-article:17575071 | pubmed:author | pubmed-author:VuMinh DiemMD | lld:pubmed |
pubmed-article:17575071 | pubmed:author | pubmed-author:KilleenNigelN | lld:pubmed |
pubmed-article:17575071 | pubmed:author | pubmed-author:KroemerAlexan... | lld:pubmed |
pubmed-article:17575071 | pubmed:author | pubmed-author:XiaoXiangX | lld:pubmed |
pubmed-article:17575071 | pubmed:author | pubmed-author:DegauqueNicol... | lld:pubmed |
pubmed-article:17575071 | pubmed:author | pubmed-author:Chang LiXianX | lld:pubmed |
pubmed-article:17575071 | pubmed:issnType | Print | lld:pubmed |
pubmed-article:17575071 | pubmed:day | 1 | lld:pubmed |
pubmed-article:17575071 | pubmed:volume | 110 | lld:pubmed |
pubmed-article:17575071 | pubmed:owner | NLM | lld:pubmed |
pubmed-article:17575071 | pubmed:authorsComplete | Y | lld:pubmed |
pubmed-article:17575071 | pubmed:pagination | 2501-10 | lld:pubmed |
pubmed-article:17575071 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
pubmed-article:17575071 | pubmed:meshHeading | pubmed-meshheading:17575071... | lld:pubmed |
pubmed-article:17575071 | pubmed:meshHeading | pubmed-meshheading:17575071... | lld:pubmed |
pubmed-article:17575071 | pubmed:meshHeading | pubmed-meshheading:17575071... | lld:pubmed |
pubmed-article:17575071 | pubmed:meshHeading | pubmed-meshheading:17575071... | lld:pubmed |
pubmed-article:17575071 | pubmed:meshHeading | pubmed-meshheading:17575071... | lld:pubmed |
pubmed-article:17575071 | pubmed:meshHeading | pubmed-meshheading:17575071... | lld:pubmed |
pubmed-article:17575071 | pubmed:meshHeading | pubmed-meshheading:17575071... | lld:pubmed |
pubmed-article:17575071 | pubmed:meshHeading | pubmed-meshheading:17575071... | lld:pubmed |
pubmed-article:17575071 | pubmed:year | 2007 | lld:pubmed |
pubmed-article:17575071 | pubmed:articleTitle | OX40 costimulation turns off Foxp3+ Tregs. | lld:pubmed |
pubmed-article:17575071 | pubmed:affiliation | Harvard Medical School, Transplant Research Center, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA. | lld:pubmed |
pubmed-article:17575071 | pubmed:publicationType | Journal Article | lld:pubmed |
pubmed-article:17575071 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
pubmed-article:17575071 | pubmed:publicationType | Research Support, N.I.H., Extramural | lld:pubmed |
entrez-gene:19373 | entrezgene:pubmed | pubmed-article:17575071 | lld:entrezgene |
entrez-gene:20371 | entrezgene:pubmed | pubmed-article:17575071 | lld:entrezgene |
entrez-gene:22163 | entrezgene:pubmed | pubmed-article:17575071 | lld:entrezgene |
entrez-gene:22164 | entrezgene:pubmed | pubmed-article:17575071 | lld:entrezgene |
http://linkedlifedata.com/r... | entrezgene:pubmed | pubmed-article:17575071 | lld:entrezgene |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:17575071 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:17575071 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:17575071 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:17575071 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:17575071 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:17575071 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:17575071 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:17575071 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:17575071 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:17575071 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:17575071 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:17575071 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:17575071 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:17575071 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:17575071 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:17575071 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:17575071 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:17575071 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:17575071 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:17575071 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:17575071 | lld:pubmed |