Linked Life Data

17558450

Source:http://linkedlifedata.com/resource/pubmed/id/17558450

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pubmed-article:17558450pubmed:abstractTextIn this study, a mistletoe lectin (ML) was purified from Chinese mistletoe and the effect of this 60 kDa Chinese ML on human gammadelta T cell cytotoxicity, apoptosis and modulation of the cytokine network was studied. The cytotoxic properties of delta T cells was evaluated by using a (51)Cr release test and employed fluorescence-activated cell sorting and enzyme-linked immunosorbent assay analysis to quantify translocation of the cell membrane phospholipid, phosphatidylserine and nuclear DNA fragmentation during apoptosis. It was found that: (i) ML effectively stimulated gammadelta T cell proliferation in a dose- and time-dependent manner; (ii) ML increased gammadelta T cell cytotoxicity; (iii) ML could modulate lipopolysaccharide-induced cytokine release in a pro-inflammatory manner by increasing tumor necrosis factor (TNF)-alpha release and inhibiting the release of anti-inflammatory interleukin (IL)-10; (iv) ML induced apoptosis in caspase-dependent and CD95-independent manner. The results indicated that ML is a potent immunomodulator to human gammadelta T cell cytotoxicity, apoptos is and cytokine production.lld:pubmed
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pubmed-article:17558450pubmed:articleTitleA lectin from Chinese mistletoe increases gammadelta T cell-mediated cytotoxicity through induction of caspase-dependent apoptosis.lld:pubmed
pubmed-article:17558450pubmed:affiliationShanghai Jiaotong University School of Medicine, Shanghai Institute of Immunology, Shanghai 200025, China.lld:pubmed
pubmed-article:17558450pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:17558450pubmed:publicationTypeResearch Support, Non-U.S. Gov'tlld:pubmed
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