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pubmed-article:17554116pubmed:abstractTextAmyloid A (AA) amyloidosis is a complication of chronic inflammatory conditions that develops when proteolytic fragments of serum amyloid A protein (SAA) are deposited in tissues as amyloid fibrils. Amyloid deposition in the kidney causes progressive deterioration in renal function. Eprodisate is a member of a new class of compounds designed to interfere with interactions between amyloidogenic proteins and glycosaminoglycans and thereby inhibit polymerization of amyloid fibrils and deposition of the fibrils in tissues.lld:pubmed
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pubmed-article:17554116pubmed:articleTitleEprodisate for the treatment of renal disease in AA amyloidosis.lld:pubmed
pubmed-article:17554116pubmed:affiliationBoston University School of Medicine, Boston, MA 02118, USA. ldember@bu.edulld:pubmed
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