| pubmed-article:17538612 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:17538612 | lifeskim:mentions | umls-concept:C0023980 | lld:lifeskim |
| pubmed-article:17538612 | lifeskim:mentions | umls-concept:C0027882 | lld:lifeskim |
| pubmed-article:17538612 | lifeskim:mentions | umls-concept:C0162610 | lld:lifeskim |
| pubmed-article:17538612 | lifeskim:mentions | umls-concept:C0086597 | lld:lifeskim |
| pubmed-article:17538612 | pubmed:issue | 7144 | lld:pubmed |
| pubmed-article:17538612 | pubmed:dateCreated | 2007-5-31 | lld:pubmed |
| pubmed-article:17538612 | pubmed:abstractText | Dietary restriction extends lifespan and retards age-related disease in many species and profoundly alters endocrine function in mammals. However, no causal role of any hormonal signal in diet-restricted longevity has been demonstrated. Here we show that increased longevity of diet-restricted Caenorhabditis elegans requires the transcription factor gene skn-1 acting in the ASIs, a pair of neurons in the head. Dietary restriction activates skn-1 in these two neurons, which signals peripheral tissues to increase metabolic activity. These findings demonstrate that increased lifespan in a diet-restricted metazoan depends on cell non-autonomous signalling from central neuronal cells to non-neuronal body tissues, and suggest that the ASI neurons mediate diet-restriction-induced longevity by an endocrine mechanism. | lld:pubmed |
| pubmed-article:17538612 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17538612 | pubmed:language | eng | lld:pubmed |
| pubmed-article:17538612 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17538612 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:17538612 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:17538612 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:17538612 | pubmed:month | May | lld:pubmed |
| pubmed-article:17538612 | pubmed:issn | 1476-4687 | lld:pubmed |
| pubmed-article:17538612 | pubmed:author | pubmed-author:GuarenteLeona... | lld:pubmed |
| pubmed-article:17538612 | pubmed:author | pubmed-author:BishopNichola... | lld:pubmed |
| pubmed-article:17538612 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:17538612 | pubmed:day | 31 | lld:pubmed |
| pubmed-article:17538612 | pubmed:volume | 447 | lld:pubmed |
| pubmed-article:17538612 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:17538612 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:17538612 | pubmed:pagination | 545-9 | lld:pubmed |
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| pubmed-article:17538612 | pubmed:meshHeading | pubmed-meshheading:17538612... | lld:pubmed |
| pubmed-article:17538612 | pubmed:year | 2007 | lld:pubmed |
| pubmed-article:17538612 | pubmed:articleTitle | Two neurons mediate diet-restriction-induced longevity in C. elegans. | lld:pubmed |
| pubmed-article:17538612 | pubmed:affiliation | Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA. | lld:pubmed |
| pubmed-article:17538612 | pubmed:publicationType | Journal Article | lld:pubmed |
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