| pubmed-article:17537977 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:17537977 | lifeskim:mentions | umls-concept:C0015780 | lld:lifeskim |
| pubmed-article:17537977 | lifeskim:mentions | umls-concept:C0034693 | lld:lifeskim |
| pubmed-article:17537977 | lifeskim:mentions | umls-concept:C0152314 | lld:lifeskim |
| pubmed-article:17537977 | lifeskim:mentions | umls-concept:C0205150 | lld:lifeskim |
| pubmed-article:17537977 | lifeskim:mentions | umls-concept:C0027893 | lld:lifeskim |
| pubmed-article:17537977 | lifeskim:mentions | umls-concept:C0021467 | lld:lifeskim |
| pubmed-article:17537977 | lifeskim:mentions | umls-concept:C1293122 | lld:lifeskim |
| pubmed-article:17537977 | lifeskim:mentions | umls-concept:C0442805 | lld:lifeskim |
| pubmed-article:17537977 | lifeskim:mentions | umls-concept:C0021469 | lld:lifeskim |
| pubmed-article:17537977 | pubmed:issue | 22 | lld:pubmed |
| pubmed-article:17537977 | pubmed:dateCreated | 2007-5-31 | lld:pubmed |
| pubmed-article:17537977 | pubmed:abstractText | The dentate gyrus filters incoming activity into the hippocampus proper. It plays a role in learning and memory and in pathological states such as epilepsy. Some of hilar interneurons of the dentate gyrus express neuropeptide Y (NPY), which modulates granule cell activity. A subpopulation of the NPY-expressing inhibitory interneurons is sensitive to seizure-induced damage. Pretreatment with beta-estradiol in ovariectomized rats protects hilar interneurons against seizure-induced injury, including the NPY-containing damage-sensitive subpopulation. Here, we demonstrate that beta-estradiol enhances NPY expression within the hilar interneurons. In vitro paired-pulse stimulation of the mixed perforant path revealed beta-estradiol-induced augmentation of granule cell network inhibition, which at interstimulus intervals between 200 and 300 ms (corresponding to approximately 3-5 Hz) was NPY sensitive and involved Y1 receptors, whereas it was insensitive to GABA(B) or metabotropic glutamate receptor antagonists. Additionally, beta-estradiol pretreatment attenuated propagation of low-frequency (3.3 or 5 Hz) burst activity through the dentate gyrus. Scavenging endogenous NPY by intracerebroventricular administration of anti-NPY antibody accelerated kainic acid-induced seizure onset and increased seizure-induced neuronal damage in the hilus compared with rats treated with beta-estradiol alone. Together, we show that beta-estradiol upregulates hilar NPY and that this leads to enhancement in dentate gyrus inhibition of incoming frequencies between 3 and 5 Hz. Such frequencies are similar to the discharge frequencies recorded during seizure initiation in some patients with epilepsy. Thus, beta-estradiol-induced NPY-sensitive filtering of 3-5 Hz frequencies may be an important regulator of incoming seizure activity, but it could also serve a physiological purpose in modulating information flow into the hippocampus proper. | lld:pubmed |
| pubmed-article:17537977 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17537977 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17537977 | pubmed:language | eng | lld:pubmed |
| pubmed-article:17537977 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17537977 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:17537977 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17537977 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17537977 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:17537977 | pubmed:month | May | lld:pubmed |
| pubmed-article:17537977 | pubmed:issn | 1529-2401 | lld:pubmed |
| pubmed-article:17537977 | pubmed:author | pubmed-author:VelísekLiborL | lld:pubmed |
| pubmed-article:17537977 | pubmed:author | pubmed-author:VelískováJana... | lld:pubmed |
| pubmed-article:17537977 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:17537977 | pubmed:day | 30 | lld:pubmed |
| pubmed-article:17537977 | pubmed:volume | 27 | lld:pubmed |
| pubmed-article:17537977 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:17537977 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:17537977 | pubmed:pagination | 6054-63 | lld:pubmed |
| pubmed-article:17537977 | pubmed:dateRevised | 2007-12-3 | lld:pubmed |
| pubmed-article:17537977 | pubmed:meshHeading | pubmed-meshheading:17537977... | lld:pubmed |
| pubmed-article:17537977 | pubmed:meshHeading | pubmed-meshheading:17537977... | lld:pubmed |
| pubmed-article:17537977 | pubmed:meshHeading | pubmed-meshheading:17537977... | lld:pubmed |
| pubmed-article:17537977 | pubmed:meshHeading | pubmed-meshheading:17537977... | lld:pubmed |
| pubmed-article:17537977 | pubmed:meshHeading | pubmed-meshheading:17537977... | lld:pubmed |
| pubmed-article:17537977 | pubmed:meshHeading | pubmed-meshheading:17537977... | lld:pubmed |
| pubmed-article:17537977 | pubmed:meshHeading | pubmed-meshheading:17537977... | lld:pubmed |
| pubmed-article:17537977 | pubmed:meshHeading | pubmed-meshheading:17537977... | lld:pubmed |
| pubmed-article:17537977 | pubmed:meshHeading | pubmed-meshheading:17537977... | lld:pubmed |
| pubmed-article:17537977 | pubmed:year | 2007 | lld:pubmed |
| pubmed-article:17537977 | pubmed:articleTitle | Beta-estradiol increases dentate gyrus inhibition in female rats via augmentation of hilar neuropeptide Y. | lld:pubmed |
| pubmed-article:17537977 | pubmed:affiliation | Saul R. Korey Department of Neurology, Laboratory of Developmental Epilepsy, Albert Einstein College of Medicine and the Einstein/Montefiore Comprehensive Epilepsy Management Center, Bronx, New York 10461, USA. jvelisko@aecom.yu.edu | lld:pubmed |
| pubmed-article:17537977 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:17537977 | pubmed:publicationType | Comparative Study | lld:pubmed |
| pubmed-article:17537977 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| pubmed-article:17537977 | pubmed:publicationType | Research Support, N.I.H., Extramural | lld:pubmed |
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