| pubmed-article:17535974 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:17535974 | lifeskim:mentions | umls-concept:C0229889 | lld:lifeskim |
| pubmed-article:17535974 | lifeskim:mentions | umls-concept:C0078058 | lld:lifeskim |
| pubmed-article:17535974 | lifeskim:mentions | umls-concept:C0020564 | lld:lifeskim |
| pubmed-article:17535974 | lifeskim:mentions | umls-concept:C1293134 | lld:lifeskim |
| pubmed-article:17535974 | lifeskim:mentions | umls-concept:C1171892 | lld:lifeskim |
| pubmed-article:17535974 | lifeskim:mentions | umls-concept:C1710082 | lld:lifeskim |
| pubmed-article:17535974 | pubmed:issue | 6 | lld:pubmed |
| pubmed-article:17535974 | pubmed:dateCreated | 2007-6-12 | lld:pubmed |
| pubmed-article:17535974 | pubmed:abstractText | Lymphatic vessel growth, or lymphangiogenesis, is regulated by vascular endothelial growth factor-C (VEGF-C) and -D via VEGF receptor 3 (VEGFR-3). Recent studies suggest that VEGF, which does not bind to VEGFR-3, can also induce lymphangiogenesis through unknown mechanisms. To dissect the receptor pathway that triggers VEGFR-3-independent lymphangiogenesis, we used both transgenic and adenoviral overexpression of placenta growth factor (PlGF) and VEGF-E, which are specific activators of VEGFR-1 and -2, respectively. Unlike PlGF, VEGF-E induced circumferential lymphatic vessel hyperplasia, but essentially no new vessel sprouting, when transduced into mouse skin via adenoviral vectors. This effect was not inhibited by blocking VEGF-C and -D. Postnatal lymphatic hyperplasia, without increased density of lymphatic vessels, was also detected in transgenic mice expressing VEGF-E in the skin, but not in mice expressing PlGF. Surprisingly, VEGF-E induced lymphatic hyperplasia postnatally, and it did not rescue the loss of lymphatic vessels in transgenic embryos where VEGF-C and VEGF-D were blocked. Our data suggests that VEGFR-2 signals promote lymphatic vessel enlargement, but unlike in the blood vessels, are not involved in vessel sprouting to generate new lymphatic vessels in vivo. | lld:pubmed |
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| pubmed-article:17535974 | pubmed:language | eng | lld:pubmed |
| pubmed-article:17535974 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17535974 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:17535974 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:17535974 | pubmed:month | Jun | lld:pubmed |
| pubmed-article:17535974 | pubmed:issn | 0022-1007 | lld:pubmed |
| pubmed-article:17535974 | pubmed:author | pubmed-author:Ylä-Herttuala... | lld:pubmed |
| pubmed-article:17535974 | pubmed:author | pubmed-author:AlitaloKariK | lld:pubmed |
| pubmed-article:17535974 | pubmed:author | pubmed-author:ShibuyaMasabu... | lld:pubmed |
| pubmed-article:17535974 | pubmed:author | pubmed-author:ZambrunoGiova... | lld:pubmed |
| pubmed-article:17535974 | pubmed:author | pubmed-author:DvorakHarold... | lld:pubmed |
| pubmed-article:17535974 | pubmed:author | pubmed-author:OdorisioTeres... | lld:pubmed |
| pubmed-article:17535974 | pubmed:author | pubmed-author:HeYulongY | lld:pubmed |
| pubmed-article:17535974 | pubmed:author | pubmed-author:NagyJanice... | lld:pubmed |
| pubmed-article:17535974 | pubmed:author | pubmed-author:TammelaTuomas... | lld:pubmed |
| pubmed-article:17535974 | pubmed:author | pubmed-author:WirzeniusMari... | lld:pubmed |
| pubmed-article:17535974 | pubmed:author | pubmed-author:UutelaMarkoM | lld:pubmed |
| pubmed-article:17535974 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:17535974 | pubmed:day | 11 | lld:pubmed |
| pubmed-article:17535974 | pubmed:volume | 204 | lld:pubmed |
| pubmed-article:17535974 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:17535974 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:17535974 | pubmed:pagination | 1431-40 | lld:pubmed |
| pubmed-article:17535974 | pubmed:dateRevised | 2009-11-25 | lld:pubmed |
| pubmed-article:17535974 | pubmed:meshHeading | pubmed-meshheading:17535974... | lld:pubmed |
| pubmed-article:17535974 | pubmed:meshHeading | pubmed-meshheading:17535974... | lld:pubmed |
| pubmed-article:17535974 | pubmed:meshHeading | pubmed-meshheading:17535974... | lld:pubmed |
| pubmed-article:17535974 | pubmed:meshHeading | pubmed-meshheading:17535974... | lld:pubmed |
| pubmed-article:17535974 | pubmed:meshHeading | pubmed-meshheading:17535974... | lld:pubmed |
| pubmed-article:17535974 | pubmed:meshHeading | pubmed-meshheading:17535974... | lld:pubmed |
| pubmed-article:17535974 | pubmed:meshHeading | pubmed-meshheading:17535974... | lld:pubmed |
| pubmed-article:17535974 | pubmed:meshHeading | pubmed-meshheading:17535974... | lld:pubmed |
| pubmed-article:17535974 | pubmed:meshHeading | pubmed-meshheading:17535974... | lld:pubmed |
| pubmed-article:17535974 | pubmed:meshHeading | pubmed-meshheading:17535974... | lld:pubmed |
| pubmed-article:17535974 | pubmed:meshHeading | pubmed-meshheading:17535974... | lld:pubmed |
| pubmed-article:17535974 | pubmed:meshHeading | pubmed-meshheading:17535974... | lld:pubmed |
| pubmed-article:17535974 | pubmed:meshHeading | pubmed-meshheading:17535974... | lld:pubmed |
| pubmed-article:17535974 | pubmed:meshHeading | pubmed-meshheading:17535974... | lld:pubmed |
| pubmed-article:17535974 | pubmed:year | 2007 | lld:pubmed |
| pubmed-article:17535974 | pubmed:articleTitle | Distinct vascular endothelial growth factor signals for lymphatic vessel enlargement and sprouting. | lld:pubmed |
| pubmed-article:17535974 | pubmed:affiliation | Molecular/Cancer Biology Laboratory and Ludwig Institute for Cancer Research, Haartman Institute and Helsinki University Hospital, Biomedicum Helsinki, University of Helsinki, 00014 Helsinki, Finland. | lld:pubmed |
| pubmed-article:17535974 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:17535974 | pubmed:publicationType | Comparative Study | lld:pubmed |
| pubmed-article:17535974 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| pubmed-article:17535974 | pubmed:publicationType | Research Support, N.I.H., Extramural | lld:pubmed |
