| pubmed-article:17515731 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:17515731 | lifeskim:mentions | umls-concept:C0225326 | lld:lifeskim |
| pubmed-article:17515731 | lifeskim:mentions | umls-concept:C0085590 | lld:lifeskim |
| pubmed-article:17515731 | lifeskim:mentions | umls-concept:C0035868 | lld:lifeskim |
| pubmed-article:17515731 | lifeskim:mentions | umls-concept:C0017110 | lld:lifeskim |
| pubmed-article:17515731 | lifeskim:mentions | umls-concept:C0220825 | lld:lifeskim |
| pubmed-article:17515731 | lifeskim:mentions | umls-concept:C0554804 | lld:lifeskim |
| pubmed-article:17515731 | lifeskim:mentions | umls-concept:C0678640 | lld:lifeskim |
| pubmed-article:17515731 | lifeskim:mentions | umls-concept:C1999177 | lld:lifeskim |
| pubmed-article:17515731 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:17515731 | pubmed:dateCreated | 2007-5-22 | lld:pubmed |
| pubmed-article:17515731 | pubmed:abstractText | Supplemental oxygenation and carbon dioxide removal through an intravenous respiratory assist catheter can be used as a means of treating patients with acute respiratory failure. We are beginning development efforts toward a new respiratory assist catheter with an insertional size <25F, which can be inserted percutaneously. In this study, we evaluated fiber bundle rotation as an improved mechanism for active mixing and enhanced gas exchange in intravenous respiratory assist catheters. Using a simple test apparatus of a rotating densely packed bundle of hollow fiber membranes, water and blood gas exchange levels were evaluated at various rotation speeds in a mock vena cava. At 12,000 RPM, maximum CO2 gas exchange rates were 449 and 523 mL/min per m2, water and blood, respectively, but the rate of increase with increasing rotation rate diminished beyond 7500 RPM. These levels of gas exchange efficiency are two- to threefold greater than achieved in our previous respiratory catheters using balloon pulsation for active mixing. In preliminary hemolysis tests, which monitored plasma-free hemoglobin levels in vitro over a period of 6 hours, we established that the rotating fiber bundle per se did not cause significant blood hemolysis compared with an intra-aortic balloon pump. Accordingly, fiber bundle rotation appears to be a potential mechanism for increasing gas exchange and reducing insertional size in respiratory catheters. | lld:pubmed |
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| pubmed-article:17515731 | pubmed:language | eng | lld:pubmed |
| pubmed-article:17515731 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17515731 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:17515731 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:17515731 | pubmed:issn | 1538-943X | lld:pubmed |
| pubmed-article:17515731 | pubmed:author | pubmed-author:FederspielWil... | lld:pubmed |
| pubmed-article:17515731 | pubmed:author | pubmed-author:HattlerBrack... | lld:pubmed |
| pubmed-article:17515731 | pubmed:author | pubmed-author:EashHeide JHJ | lld:pubmed |
| pubmed-article:17515731 | pubmed:author | pubmed-author:FrankowskiBri... | lld:pubmed |
| pubmed-article:17515731 | pubmed:author | pubmed-author:MihelcKevin... | lld:pubmed |
| pubmed-article:17515731 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:17515731 | pubmed:volume | 53 | lld:pubmed |
| pubmed-article:17515731 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:17515731 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:17515731 | pubmed:pagination | 368-73 | lld:pubmed |
| pubmed-article:17515731 | pubmed:dateRevised | 2011-9-26 | lld:pubmed |
| pubmed-article:17515731 | pubmed:meshHeading | pubmed-meshheading:17515731... | lld:pubmed |
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| pubmed-article:17515731 | pubmed:meshHeading | pubmed-meshheading:17515731... | lld:pubmed |
| pubmed-article:17515731 | pubmed:articleTitle | Evaluation of fiber bundle rotation for enhancing gas exchange in a respiratory assist catheter. | lld:pubmed |
| pubmed-article:17515731 | pubmed:affiliation | Medical Devices Laboratory, University of Pittsburgh, Pittsburgh, Pennsylvania 15203, USA. | lld:pubmed |
| pubmed-article:17515731 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:17515731 | pubmed:publicationType | In Vitro | lld:pubmed |
| pubmed-article:17515731 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| pubmed-article:17515731 | pubmed:publicationType | Research Support, N.I.H., Extramural | lld:pubmed |
