| pubmed-article:17495183 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:17495183 | lifeskim:mentions | umls-concept:C1711254 | lld:lifeskim |
| pubmed-article:17495183 | lifeskim:mentions | umls-concept:C0028754 | lld:lifeskim |
| pubmed-article:17495183 | lifeskim:mentions | umls-concept:C1171304 | lld:lifeskim |
| pubmed-article:17495183 | lifeskim:mentions | umls-concept:C0332281 | lld:lifeskim |
| pubmed-article:17495183 | lifeskim:mentions | umls-concept:C1540034 | lld:lifeskim |
| pubmed-article:17495183 | lifeskim:mentions | umls-concept:C1706420 | lld:lifeskim |
| pubmed-article:17495183 | lifeskim:mentions | umls-concept:C1659987 | lld:lifeskim |
| pubmed-article:17495183 | pubmed:issue | 5 | lld:pubmed |
| pubmed-article:17495183 | pubmed:dateCreated | 2007-5-14 | lld:pubmed |
| pubmed-article:17495183 | pubmed:abstractText | We recently showed that long-term weight reduction changes the gene expression profile of adipose tissue in overweight individuals with impaired glucose tolerance (IGT). One of the responding genes was X-chromosomal tenomodulin (TNMD), a putative angiogenesis inhibitor. Our aim was to study the associations of individual single nucleotide polymorphisms and haplotypes with adiposity, glucose metabolism, and the risk of type 2 diabetes (T2D). Seven single nucleotide polymorphisms from two different haploblocks were genotyped from 507 participants of the Finnish Diabetes Prevention Study (DPS). Sex-specific genotype effects were observed. Three markers of haploblock 1 were associated with features of adiposity in women (rs5966709, rs4828037) and men (rs11798018). Markers rs2073163 and rs1155794 from haploblock 2 were associated with 2-hour plasma glucose levels in men during the 3-year follow-up. The same two markers together with rs2073162 associated with the conversion of IGT to T2D in men. The risk of developing T2D was approximately 2-fold in individuals with genotypes associated with higher 2-hour plasma glucose levels; the hazard ratios were 2.192 (p = 0.025) for rs2073162-A, 2.191 (p = 0.027) for rs2073163-C, and 1.998 (p = 0.054) for rs1155974-T. These results suggest that TNMD polymorphisms are associated with adiposity and also with glucose metabolism and conversion from IGT to T2D in men. | lld:pubmed |
| pubmed-article:17495183 | pubmed:language | eng | lld:pubmed |
| pubmed-article:17495183 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17495183 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:17495183 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17495183 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17495183 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:17495183 | pubmed:month | May | lld:pubmed |
| pubmed-article:17495183 | pubmed:issn | 1930-7381 | lld:pubmed |
| pubmed-article:17495183 | pubmed:author | pubmed-author:Finnish... | lld:pubmed |
| pubmed-article:17495183 | pubmed:author | pubmed-author:TuomilehtoJaa... | lld:pubmed |
| pubmed-article:17495183 | pubmed:author | pubmed-author:UusitupaMatti... | lld:pubmed |
| pubmed-article:17495183 | pubmed:author | pubmed-author:PulkkinenLeen... | lld:pubmed |
| pubmed-article:17495183 | pubmed:author | pubmed-author:LindströmJaan... | lld:pubmed |
| pubmed-article:17495183 | pubmed:author | pubmed-author:SchwabUrsulaU | lld:pubmed |
| pubmed-article:17495183 | pubmed:author | pubmed-author:KolehmainenMa... | lld:pubmed |
| pubmed-article:17495183 | pubmed:author | pubmed-author:TolppanenAnna... | lld:pubmed |
| pubmed-article:17495183 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:17495183 | pubmed:volume | 15 | lld:pubmed |
| pubmed-article:17495183 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:17495183 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:17495183 | pubmed:pagination | 1082-8 | lld:pubmed |
| pubmed-article:17495183 | pubmed:dateRevised | 2008-1-21 | lld:pubmed |
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| pubmed-article:17495183 | pubmed:meshHeading | pubmed-meshheading:17495183... | lld:pubmed |
| pubmed-article:17495183 | pubmed:meshHeading | pubmed-meshheading:17495183... | lld:pubmed |
| pubmed-article:17495183 | pubmed:meshHeading | pubmed-meshheading:17495183... | lld:pubmed |
| pubmed-article:17495183 | pubmed:meshHeading | pubmed-meshheading:17495183... | lld:pubmed |
| pubmed-article:17495183 | pubmed:meshHeading | pubmed-meshheading:17495183... | lld:pubmed |
| pubmed-article:17495183 | pubmed:meshHeading | pubmed-meshheading:17495183... | lld:pubmed |
| pubmed-article:17495183 | pubmed:meshHeading | pubmed-meshheading:17495183... | lld:pubmed |
| pubmed-article:17495183 | pubmed:year | 2007 | lld:pubmed |
| pubmed-article:17495183 | pubmed:articleTitle | Tenomodulin is associated with obesity and diabetes risk: the Finnish diabetes prevention study. | lld:pubmed |
| pubmed-article:17495183 | pubmed:affiliation | Department of Clinical Nutrition and Food and Health Research Centre, University of Kuopio, PO Box 1627, 70211 Kuopio, Finland. Anna-Maija.Tolppanen@uku.fi | lld:pubmed |
| pubmed-article:17495183 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:17495183 | pubmed:publicationType | Randomized Controlled Trial | lld:pubmed |
| pubmed-article:17495183 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| pubmed-article:17495183 | pubmed:publicationType | Multicenter Study | lld:pubmed |
| entrez-gene:64102 | entrezgene:pubmed | pubmed-article:17495183 | lld:entrezgene |
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| lhgdn:association:36053 | lhgdn:found_in | pubmed-article:17495183 | lld:lhgdn |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:17495183 | lld:pubmed |
