| pubmed-article:17429623 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:17429623 | lifeskim:mentions | umls-concept:C0030705 | lld:lifeskim |
| pubmed-article:17429623 | lifeskim:mentions | umls-concept:C0280100 | lld:lifeskim |
| pubmed-article:17429623 | lifeskim:mentions | umls-concept:C0123931 | lld:lifeskim |
| pubmed-article:17429623 | lifeskim:mentions | umls-concept:C0205390 | lld:lifeskim |
| pubmed-article:17429623 | lifeskim:mentions | umls-concept:C0201734 | lld:lifeskim |
| pubmed-article:17429623 | lifeskim:mentions | umls-concept:C0205195 | lld:lifeskim |
| pubmed-article:17429623 | lifeskim:mentions | umls-concept:C0950721 | lld:lifeskim |
| pubmed-article:17429623 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:17429623 | pubmed:dateCreated | 2007-12-17 | lld:pubmed |
| pubmed-article:17429623 | pubmed:abstractText | 7-Hydroxystaurosporine (UCN-01) is a protein kinase inhibitor that inhibits several serine-threonine kinases including PKC and PDK1. Due to the preclinical synergistic effects seen with topoisomerase I inhibitors and non-overlapping toxicity, UCN-01 and irinotecan were combined in a dose-finding study designed to determine the maximum tolerated dose (MTD), toxicity profile, and pharmacokinetics (PK) of UCN-01 and irinotecan. | lld:pubmed |
| pubmed-article:17429623 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17429623 | pubmed:language | eng | lld:pubmed |
| pubmed-article:17429623 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17429623 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:17429623 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17429623 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:17429623 | pubmed:month | Mar | lld:pubmed |
| pubmed-article:17429623 | pubmed:issn | 0344-5704 | lld:pubmed |
| pubmed-article:17429623 | pubmed:author | pubmed-author:DonehowerRoss... | lld:pubmed |
| pubmed-article:17429623 | pubmed:author | pubmed-author:BakerSharyn... | lld:pubmed |
| pubmed-article:17429623 | pubmed:author | pubmed-author:HidalgoManuel... | lld:pubmed |
| pubmed-article:17429623 | pubmed:author | pubmed-author:RudekMichelle... | lld:pubmed |
| pubmed-article:17429623 | pubmed:author | pubmed-author:DanceyJanetJ | lld:pubmed |
| pubmed-article:17429623 | pubmed:author | pubmed-author:CarducciMicha... | lld:pubmed |
| pubmed-article:17429623 | pubmed:author | pubmed-author:JimenoAntonio... | lld:pubmed |
| pubmed-article:17429623 | pubmed:author | pubmed-author:LaheruDaniel... | lld:pubmed |
| pubmed-article:17429623 | pubmed:author | pubmed-author:MessersmithWe... | lld:pubmed |
| pubmed-article:17429623 | pubmed:author | pubmed-author:PurcellThomas... | lld:pubmed |
| pubmed-article:17429623 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:17429623 | pubmed:volume | 61 | lld:pubmed |
| pubmed-article:17429623 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:17429623 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:17429623 | pubmed:pagination | 423-33 | lld:pubmed |
| pubmed-article:17429623 | pubmed:dateRevised | 2010-11-18 | lld:pubmed |
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| pubmed-article:17429623 | pubmed:meshHeading | pubmed-meshheading:17429623... | lld:pubmed |
| pubmed-article:17429623 | pubmed:meshHeading | pubmed-meshheading:17429623... | lld:pubmed |
| pubmed-article:17429623 | pubmed:meshHeading | pubmed-meshheading:17429623... | lld:pubmed |
| pubmed-article:17429623 | pubmed:meshHeading | pubmed-meshheading:17429623... | lld:pubmed |
| pubmed-article:17429623 | pubmed:year | 2008 | lld:pubmed |
| pubmed-article:17429623 | pubmed:articleTitle | Phase I and pharmacokinetic study of UCN-01 in combination with irinotecan in patients with solid tumors. | lld:pubmed |
| pubmed-article:17429623 | pubmed:affiliation | The Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University, Cancer Research Building I, Baltimore, MD, USA. | lld:pubmed |
| pubmed-article:17429623 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:17429623 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| pubmed-article:17429623 | pubmed:publicationType | Clinical Trial, Phase I | lld:pubmed |
| pubmed-article:17429623 | pubmed:publicationType | Research Support, N.I.H., Extramural | lld:pubmed |
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