| pubmed-article:17428727 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:17428727 | lifeskim:mentions | umls-concept:C0007600 | lld:lifeskim |
| pubmed-article:17428727 | lifeskim:mentions | umls-concept:C0330199 | lld:lifeskim |
| pubmed-article:17428727 | lifeskim:mentions | umls-concept:C0162638 | lld:lifeskim |
| pubmed-article:17428727 | lifeskim:mentions | umls-concept:C0178539 | lld:lifeskim |
| pubmed-article:17428727 | lifeskim:mentions | umls-concept:C1527148 | lld:lifeskim |
| pubmed-article:17428727 | lifeskim:mentions | umls-concept:C0936012 | lld:lifeskim |
| pubmed-article:17428727 | pubmed:issue | 5 | lld:pubmed |
| pubmed-article:17428727 | pubmed:dateCreated | 2007-5-7 | lld:pubmed |
| pubmed-article:17428727 | pubmed:abstractText | A comparative lipidomics approach was employed to investigate the changes in membrane phospholipids during the procession of cellular development and apoptosis of two plant cell lines, Taxus cuspidata and Taxus chinensis var. mairei. Analysis of lipids by LC/ESI/MS(n) showed more than 90 phospholipid molecular species and indicated significant differences in the abundance throughout a 3-week period. Phosphatidic acid (PA), phosphatidylcholine (PC) and lysophosphatidylcholine (LysoPC) were three important lipid groups that were responsible for the discrimination between the apoptotic T. chinensis var. mairei and living T. cuspidata cells. Continuous increase of phospholipase D (PLD) activity led to PA production in apoptotic T. chinensis var. mairei cells suggesting that the PLD activation and PA formation mediated the apoptosis. Comparison of the profiles of phosphatidylbutanol (PtdBut) with those of PC or phosphatidylethanolamine (PE) indicated that PC rather than PE was the major substrate of PLD in vivo. These results suggest that the alternation of membrane phospholipids may regulate apoptosis, triggering an increase in taxol production of T. chinensis var. mairei cells. | lld:pubmed |
| pubmed-article:17428727 | pubmed:language | eng | lld:pubmed |
| pubmed-article:17428727 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17428727 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:17428727 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17428727 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17428727 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17428727 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:17428727 | pubmed:month | May | lld:pubmed |
| pubmed-article:17428727 | pubmed:issn | 0006-3002 | lld:pubmed |
| pubmed-article:17428727 | pubmed:author | pubmed-author:SnowJJJr | lld:pubmed |
| pubmed-article:17428727 | pubmed:author | pubmed-author:SongYangY | lld:pubmed |
| pubmed-article:17428727 | pubmed:author | pubmed-author:YuanYing-JinY... | lld:pubmed |
| pubmed-article:17428727 | pubmed:author | pubmed-author:LuShu-HuanSH | lld:pubmed |
| pubmed-article:17428727 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:17428727 | pubmed:volume | 1771 | lld:pubmed |
| pubmed-article:17428727 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:17428727 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:17428727 | pubmed:pagination | 600-12 | lld:pubmed |
| pubmed-article:17428727 | pubmed:meshHeading | pubmed-meshheading:17428727... | lld:pubmed |
| pubmed-article:17428727 | pubmed:meshHeading | pubmed-meshheading:17428727... | lld:pubmed |
| pubmed-article:17428727 | pubmed:meshHeading | pubmed-meshheading:17428727... | lld:pubmed |
| pubmed-article:17428727 | pubmed:meshHeading | pubmed-meshheading:17428727... | lld:pubmed |
| pubmed-article:17428727 | pubmed:meshHeading | pubmed-meshheading:17428727... | lld:pubmed |
| pubmed-article:17428727 | pubmed:meshHeading | pubmed-meshheading:17428727... | lld:pubmed |
| pubmed-article:17428727 | pubmed:meshHeading | pubmed-meshheading:17428727... | lld:pubmed |
| pubmed-article:17428727 | pubmed:meshHeading | pubmed-meshheading:17428727... | lld:pubmed |
| pubmed-article:17428727 | pubmed:year | 2007 | lld:pubmed |
| pubmed-article:17428727 | pubmed:articleTitle | Comparative lipidomics analysis of cellular development and apoptosis in two Taxus cell lines. | lld:pubmed |
| pubmed-article:17428727 | pubmed:affiliation | Department of Pharmaceutical Engineering, School of Chemical Engineering and Technology, Tianjin University, Tianjin 300072, PR China. | lld:pubmed |
| pubmed-article:17428727 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:17428727 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:17428727 | lld:pubmed |
