| pubmed-article:17416347 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:17416347 | lifeskim:mentions | umls-concept:C0021368 | lld:lifeskim |
| pubmed-article:17416347 | lifeskim:mentions | umls-concept:C0024432 | lld:lifeskim |
| pubmed-article:17416347 | lifeskim:mentions | umls-concept:C0538674 | lld:lifeskim |
| pubmed-article:17416347 | lifeskim:mentions | umls-concept:C0017431 | lld:lifeskim |
| pubmed-article:17416347 | lifeskim:mentions | umls-concept:C1280500 | lld:lifeskim |
| pubmed-article:17416347 | lifeskim:mentions | umls-concept:C0017262 | lld:lifeskim |
| pubmed-article:17416347 | lifeskim:mentions | umls-concept:C2911684 | lld:lifeskim |
| pubmed-article:17416347 | lifeskim:mentions | umls-concept:C0185117 | lld:lifeskim |
| pubmed-article:17416347 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:17416347 | pubmed:dateCreated | 2007-4-20 | lld:pubmed |
| pubmed-article:17416347 | pubmed:abstractText | In order to gain a more comprehensive understanding of the aetiology of apolipoprotein E4 genotype-cardiovascular disease (CVD) associations, the impact of the apoE genotype on the macrophage inflammatory response was examined. The murine monocyte-macrophage cell line (RAW 264.7) stably transfected to produce equal amounts of human apoE3 or apoE4 was used. Following LPS stimulation, apoE4-macrophages showed higher and lower concentrations of tumour necrosis factor alpha (pro-inflammatory) and interleukin 10 (anti-inflammatory), respectively, both at mRNA and protein levels. In addition, increased expression of heme oxygenase-1 (a stress-induced anti-inflammatory protein) was observed in the apoE4-cells. Furthermore, in apoE4-macrophages, an enhanced transactivation of the key redox sensitive transcription factor NF-kappaB was shown. Current data indicate that apoE4 macrophages have an altered inflammatory response, which may contribute to the higher CVD risk observed in apoE4 carriers. | lld:pubmed |
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| pubmed-article:17416347 | pubmed:language | eng | lld:pubmed |
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| pubmed-article:17416347 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:17416347 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:17416347 | pubmed:month | May | lld:pubmed |
| pubmed-article:17416347 | pubmed:issn | 0006-291X | lld:pubmed |
| pubmed-article:17416347 | pubmed:author | pubmed-author:RimbachGerald... | lld:pubmed |
| pubmed-article:17416347 | pubmed:author | pubmed-author:DulakJozefJ | lld:pubmed |
| pubmed-article:17416347 | pubmed:author | pubmed-author:MinihaneAnne-... | lld:pubmed |
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| pubmed-article:17416347 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:17416347 | pubmed:day | 25 | lld:pubmed |
| pubmed-article:17416347 | pubmed:volume | 357 | lld:pubmed |
| pubmed-article:17416347 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:17416347 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:17416347 | pubmed:pagination | 319-24 | lld:pubmed |
| pubmed-article:17416347 | pubmed:dateRevised | 2010-9-16 | lld:pubmed |
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| pubmed-article:17416347 | pubmed:year | 2007 | lld:pubmed |
| pubmed-article:17416347 | pubmed:articleTitle | Effects of apoE genotype on macrophage inflammation and heme oxygenase-1 expression. | lld:pubmed |
| pubmed-article:17416347 | pubmed:affiliation | Institute of Human Nutrition and Food Science, Christian Albrechts University of Kiel, Hermann-Rodewald-Strasse 6, 24098 Kiel, Germany. | lld:pubmed |
| pubmed-article:17416347 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:17416347 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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